The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Inappropriate Sympathetic Activation at Onset of Septic Shock: A Spectral Analysis Approach
Abstract
The autonomic cardiovascular control was investigated in 10 patients with septic shock, 10 patients with sepsis syndrome, and six tilted healthy subjects. Overall variability, high- and low-frequency components (AUC, HF, and LF, beats/min(2)/Hz or mm Hg(2)/Hz) from heart rate (HR), systolic (SBP) and diastolic (DBP) blood pressures spectra were obtained from 5-min recordings. LF(HR)/HF(HR) and the square root of LF(SBP)/LF(HR) (alpha) were used as indices of sympathovagal interaction and baroreflex control of the heart, respectively. Compared with tilted control subjects and patients with sepsis syndrome, septic shock is characterized by reduction in: (1) HR variability, i.e., decreased AUC(HR) (p = 0.007), LF(HR) (p = 0.002), and LF(HR)/HF(HR) (p = 0.0002); (2) DBP variability, i.e., decreased AUC(DBP) (p = 0.003) and LF(DBP) (p = 0.001), (3) alpha (p = 0.003). In septic shock, LF(HR)/HF(HR), alpha, and LF(DBP) correlated with mean blood pressure (r = 0.67, p = 0.04, r = 0.64, p = 0.03, and r = 0.88, p = 0.0008, respectively), and with plasma norepinephrine levels (r = -0.65, p = 0.03, r = -0.79, p = 0.006, and r = -0.69, p = 0.03, respectively). In conclusion, onset of septic shock is characterized by high concentrations of circulating catecholamines but impaired sympathetic modulation on heart and vessels, suggesting that central autonomic regulatory impairment contributes to circulatory failure.
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Cites
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Cited by
Harmful molecular mechanisms in sepsis
Rittirsch, D., Flierl, M. A., & Ward, P. A. (2008) · Nature Reviews Immunology · doi:10.1038/nri2402 · Cited by 1,202
Sharshar, T., Gray, F., de la Grandmaison, G. L., Hopklnson, N. S., Ross, E., Dorandeu, A., Orlikowski, D., Raphael, J.-C., Gajdos, P., & Annane, D. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14899-4 · Cited by 341
Self-citationSeptic-Associated Encephalopathy: a Comprehensive Review
Mazeraud, A., Righy, C., Bouchereau, E., Benghanem, S., Bozza, F. A., & Sharshar, T. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00862-1 · Cited by 328
Self-citationSpectral Analysis of Heart Rate Variability: Time Window Matters
Li, K., Rüdiger, H., & Ziemssen, T. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00545 · Cited by 215
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Metadata
- Authors
- ANNANE, D., TRABOLD, F., SHARSHAR, T., JARRIN, I., BLANC, A. S., RAPHAEL, J. C., & GAJDOS, P.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-08-01
- Volume
- 160
- Issue
- 2
- Pages
- 458-465
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1820594263
- Cited by
- 296
- References
- 30
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- ANNANE, D., TRABOLD, F., SHARSHAR, T., JARRIN, I., BLANC, A. S., RAPHAEL, J. C., & GAJDOS, P. (1999). Inappropriate Sympathetic Activation at Onset of Septic Shock: A Spectral Analysis Approach. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.160.2.9810073
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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