The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
The Relationship between Airways Inflammation and Asthma Severity
Abstract
In order to investigate the relationship between airways inflammation and disease severity, and improve the understanding of persistent asthma, 74 asthmatics, with disease severity ranging from intermittent, to mild to moderate and severe persistent (classified according to the Global Initiative for Asthma [GINA] guidelines), and 22 nonatopic control subjects were studied using the method of induced sputum. Sputum was analyzed for total and differential cell counts concentrations of albumin, and levels of eosinophil cationic protein (ECP), myeloperoxidase (MPO), and tryptase, inflammatory mediators reflecting eosinophil, neutrophil, and mast cell activation. Asthma severity (assessed by FEV(1), peak expiratory flow [PEF] variability, and daily symptom scores) and methacholine airways responsiveness were related to sputum eosinophilia and ECP. In addition, sputum neutrophilia and MPO levels correlated, albeit weakly, with PEF variability and symptom scores, respectively. Tryptase concentrations were raised in mild to moderate asthmatics. Albumin concentrations were significantly raised across the spectrum of asthma severity and correlated with those of tryptase and ECP. Despite treatment with either high doses of inhaled corticosteroids or oral corticosteroids, prominent eosinophilic inflammation with raised ECP was noted. This study points to persistent, disease severity-related airways inflammation in asthma, involving eosinophils, mast cells, and neutrophils, which is evident despite treatment with corticosteroids.
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Cites
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Eosinophilic Inflammation in Asthma
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Use of induced sputum cell counts to investigate airway inflammation in asthma.
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Effect of an Inhaled Corticosteroid on Airway Inflammation and Symptoms in Asthma
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Self-citationEosinophil-associated TGF- β 1 mRNA Expression and Airways Fibrosis in Bronchial Asthma
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Cited by
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Chung, K. F., Wenzel, S. E., Brozek, J. L., Bush, A., Castro, M., Sterk, P. J., Adcock, I. M., Bateman, E. D., Bel, E. H., Bleecker, E. R., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00202013 · Cited by 3,926
Asthma: defining of the persistent adult phenotypes
Wenzel, S. E. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69290-8 · Cited by 1,043
Airway Structural Alterations Selectively Associated with Severe Asthma
Benayoun, L., Druilhe, A., Dombret, M.-C., Aubier, M., & Pretolani, M. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200209-1030oc · Cited by 800
The ENFUMOSA Study Group (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00261903 · Cited by 759
Heterogeneity of Airway Inflammation in Persistent Asthma
Gibson, P. G., Simpson, J. L., & Saltos, N. (2001) · Chest · doi:10.1378/chest.119.5.1329 · Cited by 527
Metadata
- Authors
- LOUIS, R., LAU, L. C. K., BRON, A. O., ROLDAAN, A. C., RADERMECKER, M., & DJUKANOVIĆ, R.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01-01
- Volume
- 161
- Issue
- 1
- Pages
- 9-16
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2003199954
- Cited by
- 571
- References
- 32
- FWCI
- 22.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- LOUIS, R., LAU, L. C. K., BRON, A. O., ROLDAAN, A. C., RADERMECKER, M., & DJUKANOVIĆ, R. (2000). The Relationship between Airways Inflammation and Asthma Severity. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.161.1.9802048
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
