Asthma: From Bronchoconstriction to Airways Inflammation and Remodeling

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Quantitative Analysis of Bronchial Wall Vascularity in the Medium and Small Airways of Patients With Asthma and COPD

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Nature of airway inflammation and remodeling in chronic cough

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Reduced Airway Distensibility, Fixed Airflow Limitation, and Airway Wall Remodeling in Asthma

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Measurement of Bronchial and Alveolar Nitric Oxide Production in Normal Children and Children with Asthma

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Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment

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NF-κB Activation in Airways Modulates Allergic Inflammation but Not Hyperresponsiveness

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Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives

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Airway remodelling in the pathogenesis of asthma

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The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications

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Rapid Activation of Nuclear Factor-κB in Airway Epithelium in a Murine Model of Allergic Airway Inflammation

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Targeting chemokine receptors in chronic inflammatory diseases: An extensive review

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Airway Smooth Muscle Hyperproliferation Is Regulated by MicroRNA-221 in Severe Asthma

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Role of small airways in asthma: Investigation using high-resolution computed tomography

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Inhibition of Inflammation and Remodeling by Roflumilast and Dexamethasone in Murine Chronic Asthma

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Increased arginase activity underlies allergen‐induced deficiency of cNOS‐derived nitric oxide and airway hyperresponsiveness

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The association of sensitive systemic inflammation markers with bronchial asthma

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Arginase and pulmonary diseases

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The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention

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Mechanical Stress Triggers Selective Release of Fibrotic Mediators from Bronchial Epithelium

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Sounding the alarmins—The role of alarmin cytokines in asthma

Gauvreau, G. M., Bergeron, C., Boulet, L., Cockcroft, D. W., Côté, A., Davis, B. E., Leigh, R., Myers, I., O’Byrne, P. M., & Sehmi, R. (2022) · Allergy · doi:10.1111/all.15609 · Cited by 154

Potential effector and immunoregulatory functions of mast cells in mucosal immunity

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S2k-Leitlinie zur Diagnostik und Therapie von Patienten mit Asthma

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CHRONIC EFFECTS OF MECHANICAL FORCE ON AIRWAYS

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Regular treatment with formoterol for chronic asthma: serious adverse events

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Fibrocytes in lung disease

Gomperts, B. N., & Strieter, R. M. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0906587 · Cited by 141

Steroid-Resistant Neutrophilic Inflammation in a Mouse Model of an Acute Exacerbation of Asthma

Ito, K., Herbert, C. A., Siegle, J. S., Vuppusetty, C., Hansbro, N. G., Thomas, P. S., Foster, P. S., Barnes, P. J., & Kumar, R. K. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0028oc · Cited by 141

Airway remodelling in children with cystic fibrosis

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Eosinophils Regulate Dendritic Cells and Th2 Pulmonary Immune Responses following Allergen Provocation

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Effect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthma

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Inhibition of Th1- and Th2-Mediated Airway Inflammation by the Sphingosine 1-Phosphate Receptor Agonist FTY720

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Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation

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Treating asthma means treating airway smooth muscle cells

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Eosinophils in the pathogenesis of allergic airways disease

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PPAR‐gamma modulates allergic inflammation through up‐regulation of PTEN

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Eosinophil-Derived Cationic Proteins Activate the Synthesis of Remodeling Factors by Airway Epithelial Cells

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Role of RhoA Inactivation in Reduced Cell Proliferation of Human Airway Smooth Muscle by Simvastatin

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Fluticasone Inhibits But Does Not Reverse Allergen-Induced Structural Airway Changes

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Allergic rhinitis and asthma: inflammation in a one-airway condition

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CCL26/eotaxin-3 is more effective to induce the migration of eosinophils of asthmatics than CCL11/eotaxin-1 and CCL24/eotaxin-2

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Comparison of asthma phenotypes in OVA-induced mice challenged via inhaled and intranasal routes

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Asthma is associated with single‐nucleotide polymorphisms in ADAM33

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Phosphodiesterase-4 Inhibitors in the Treatment of Inflammatory Lung Disease

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Repeated pulmonary exposure to single-walled carbon nanotubes exacerbates allergic inflammation of the airway: Possible role of oxidative stress

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Calcitonin gene-related peptide as inflammatory mediator

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Airway Obstruction Correlates with Collagenase-2 (MMP-8) Expression and Activation in Bronchial Asthma

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Nuclear Factor κB, Airway Epithelium, and Asthma: Avenues for Redox Control

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Heterogeneity of asthma according to blood inflammatory patterns

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Antigen-specific CD4+ T cells drive airway smooth muscle remodeling in experimental asthma

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EAACI position statement on asthma exacerbations and severe asthma

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Human peripheral blood eosinophils induce angiogenesis

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Understanding Asthma Using Animal Models

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Decreased Expression of Membrane IL-5 Receptor α on Human Eosinophils: II. IL-5 Down-Modulates Its Receptor Via a Proteinase-Mediated Process

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Inhaled corticosteroids and decline of lung function in community residents with asthma

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Increased Airway Vascularity in Newly Diagnosed Asthma Using a High-magnification Bronchovideoscope

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Airway hyperresponsiveness in asthma: lessons fromin vitromodel systems and animal models: Fig. 1—

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IL-4, IL-5 and IFN-γ mRNA expression in pulmonary lymphocytes in equine heaves

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Systems biology approaches to understanding Epithelial Mesenchymal Transition (EMT) in mucosal remodeling and signaling in asthma

Ijaz, T., Pazdrak, K., Kalita, M. K., König, R., Choudhary, S., Tian, B., Boldogh, I. R., & Brasier, A. R. (2014) · World Allergy Organization Journal · doi:10.1186/1939-4551-7-13 · Cited by 124

Nuclear Factor-κB Activation in Airway Epithelium Induces Inflammation and Hyperresponsiveness

Pantano, C., Ather, J. L., Alcorn, J. F., Poynter, M. E., Brown, A. L., Guala, A. S., Beuschel, S. L., Allen, G. B., Whittaker, L. A., Bevelander, M., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200707-1096oc · Cited by 122

CpG Oligodeoxynucleotides Can Reverse Th2-Associated Allergic Airway Responses and Alter the B7.1/B7.2 Expression in a Murine Model of Asthma

Serebrisky, D., Teper, A. A., Huang, C.-K., Lee, S., Zhang, T.-F., Schofield, B., Kattan, M., Sampson, H. A., & Li, X. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.10.5906 · Cited by 122

Are allergic multimorbidities and IgE polysensitization associated with the persistence or re‐occurrence of foetal type 2 signalling? The M e DALL hypothesis

Bousquet, J. J., Anto, J. M., Wickman, M. C., Keil, T. O. P., Valenta, R., Haahtela, T., Carlsen, K.-H., van Hage, M., Akdiş, C. A., Bachert, C., et al. (2015) · Allergy · doi:10.1111/all.12637 · Cited by 125

Extracellular matrix proteins differentially regulate airway smooth muscle phenotype and function

Dekkers, B. G. J., Schaafsma, D., Nelemans, S. A., Zaagsma, J., & Meurs, H. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00331.2006 · Cited by 121

Anesthesia and the child with asthma

Doherty, G. M., Chisakuta, A. M., Crean, P. M., & Shields, M. D. (2005) · Pediatric Anesthesia · doi:10.1111/j.1460-9592.2005.01602.x · Cited by 120

Understanding the mechanisms of viral induced asthma: New therapeutic directions

Hansbro, N. G., Horvat, J. C., Wark, P. A. B., & Hansbro, P. M. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.11.002 · Cited by 122

Asthma programme in Finland: a community problem needs community solutions

Haahtela, T. (2001) · Thorax · doi:10.1136/thorax.56.10.806 · Cited by 120

Bronchial Inflammation and Airway Responses to Deep Inspiration in Asthma and Chronic Obstructive Pulmonary Disease

Slats, A. M., Janssen, K., van Schadewijk, A. M., van der Plas, D. T., Schot, R., van den Aardweg, J. G., de Jongste, J. C., Hiemstra, P. S., Mauad, T., Rabe, K. F., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200612-1814oc · Cited by 118

Polycyclic aromatic hydrocarbons and childhood asthma

Karimi, P., Peters, K. O., Bidad, K., & Strickland, P. T. (2015) · European Journal of Epidemiology · doi:10.1007/s10654-015-9988-6 · Cited by 119

Severe Eosinophilic Asthma

Bakakos, A., Loukides, S., & Bakakos, P. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091375 · Cited by 119

Peroxisome proliferator activated receptor-γ modulates reactive oxygen species generation and activation of nuclear factor-κB and hypoxia-inducible factor 1α in allergic airway disease of mice

Lee, K. S., Kim, S. R., Park, S. J., Park, H. S., Min, K. H., Jin, S. M., Lee, M. K., Kim, U., & Lee, Y. C. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.03.021 · Cited by 116

Relation of oxidant-antioxidant imbalance with disease progression in patients with asthma

Husain, Q., Ahmad, A., & Shameem, M. (2012) · Annals of Thoracic Medicine · doi:10.4103/1817-1737.102182 · Cited by 116

NADPH oxidase promotes NF-kappaB activation and proliferation in human airway smooth muscle.

Brar, S., Kennedy, T., Sturrock, A., Huecksteadt, T., Quinn, M., Murphy, T. M., Chitano, P., & Hoidal, J. (2002) · American Journal of Physiology - Lung cellular and Molecular Physiology · doi:10.1152/ajplung.00206.2001 · Cited by 118

Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma

Kelly, M. M., O’Connor, T. M., Leigh, R., Otis, J., Gwozd, C., Gauvreau, G. M., Gauldie, J., & O’Byrne, P. M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.09.011 · Cited by 115

BRD4 mediates NF-κB-dependent epithelial-mesenchymal transition and pulmonary fibrosis via transcriptional elongation

Tian, B., Zhao, Y., Sun, H., Zhang, Y., Yang, J., & Brasier, A. R. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00224.2016 · Cited by 114

Role of airway epithelial cells in development of asthma and allergic rhinitis

Wang, Y., Bai, C., Li, K., Adler, K. B., & Wang, X. (2008) · Respiratory Medicine · doi:10.1016/j.rmed.2008.01.017 · Cited by 117

The histamine H4 receptor: A novel modulator of inflammatory and immune disorders

Zhang, M., Thurmond, R. L., & Dunford, P. J. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.11.008 · Cited by 113

Transcription Factors T-bet and GATA-3 Regulate Development of Airway Remodeling

Kiwamoto, T., Ishii, Y., Morishima, Y., Yoh, K., Maeda, A., Ishizaki, K., Iizuka, T., Hegab, A. E., Matsuno, Y., Homma, S., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200601-079oc · Cited by 113

Leptin and asthma in overweight children at 12 years of age

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