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Cited by 337

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Tobramycin Solution for Inhalation Reduces Sputum Pseudomonas aeruginosa Density in Bronchiectasis

BARKER, ALAN F., COUCH, LESLIE, FIEL, STANLEY B., GOTFRIED, MARK H., ILOWITE, JONATHAN, MEYER, KEITH C., O'DONNELL, ANNE, SAHN, STEVEN A., SMITH, LEWIS J., STEWART, JACK O., ABUAN, TAMMY, TULLY, HEATHER, VAN DALFSEN, JILL, WELLS, CHARLES D., QUAN, JOANNE·2000·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/ajrccm.162.2.9910086
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Abstract

We conducted a placebo-controlled, double-blind, randomized study to evaluate the microbiological efficacy and safety of inhaled tobramycin for treatment of patients with bronchiectasis and Pseudomonas aeruginosa. Patients were randomly assigned to receive either tobramycin solution for inhalation (TSI) (n = 37) or placebo (n = 37), which was self-administered twice daily for 4 wk and followed by 2-wk off-drug. At Week 4, the TSI group had a mean decrease in P. aeruginosa density of 4.54 log(10) colony-forming units (cfu)/g sputum compared with no change in the placebo group (p < 0.01). At Week 6, P. aeruginosa was eradicated in 35% of TSI patients but was detected in all placebo patients. Investigators indicated that 62% of TSI patients showed an improved medical condition compared with 38% of placebo patients (odds ratio = 2.7, 95% confidence interval [CI] 1.1 to 6.9). Tobramycin-resistant P. aeruginosa strains developed in 11% of TSI patients and 3% of placebo patients (p = 0.36). The mean percent change in FEV(1) percent predicted from Week 0 to Week 4 was similar for the TSI and placebo groups (p = 0.41). More TSI-treated patients than placebo patients reported increased cough, dyspnea, wheezing, and noncardiac chest pain, but the symptoms did not limit therapy. Additional study is warranted to further evaluate TSI in bronchiectasis patients.

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Metadata

Authors
BARKER, A. F., COUCH, L., FIEL, S. B., GOTFRIED, M. H., ILOWITE, J., MEYER, K. C., O'DONNELL, A., SAHN, S. A., SMITH, L. J., STEWART, J. O., ABUAN, T., TULLY, H., VAN DALFSEN, J., WELLS, C. D., & QUAN, J.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2000-08-01
Volume
162
Issue
2
Pages
481-485
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/ajrccm.162.2.9910086
OpenAlex
W2006907865
Cited by
337
References
17
FWCI
8.30
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Tobramycin Solution for Inhalation Reduces Sputum Pseudomonas aeruginosa Density in Bronchiectasis. https://app.cochat.ai/papers/10.1164/ajrccm.162.2.9910086
The paper
BARKER, A. F., COUCH, L., FIEL, S. B., GOTFRIED, M. H., ILOWITE, J., MEYER, K. C., O'DONNELL, A., SAHN, S. A., SMITH, L. J., STEWART, J. O., ABUAN, T., TULLY, H., VAN DALFSEN, J., WELLS, C. D., & QUAN, J. (2000). Tobramycin Solution for Inhalation Reduces Sputum Pseudomonas aeruginosa Density in Bronchiectasis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.162.2.9910086

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.