Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 302

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Gender-Related Differences in Severe, Early-Onset Chronic Obstructive Pulmonary Disease

SILVERMAN, EDWIN K., WEISS, SCOTT T., DRAZEN, JEFFREY M., CHAPMAN, HAROLD A., CAREY, VINCENT, CAMPBELL, EDWARD J., DENISH, PAUL, SILVERMAN, RACHEL A., CELEDON, JUAN C., REILLY, JOHN J., GINNS, LEO C., SPEIZER, FRANK E.·2000·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/ajrccm.162.6.2003112
Open this paper in CoChat — free account

Abstract

Men have higher prevalence rates of chronic obstructive pulmonary disease (COPD) than women, which has been attributed to the historically higher rates of cigarette smoking in males. However, the increased rates of cigarette smoking in females within the last several decades have been associated with steadily increasing rates of COPD in women. As part of a study of the genetics of severe, early-onset COPD, we assembled a group of 84 probands with severe, early-onset COPD (without severe alpha(1)-antitrypsin deficiency) and 348 of their first-degree relatives. We found a markedly elevated prevalence (71.4%) of females among the early-onset COPD probands. Among the entire group of first-degree relatives of early-onset COPD probands, univariate analysis demonstrated similar spirometric values and bronchodilator responsiveness in males and females; however, among current or ex-smokers, female first-degree relatives had significantly lower FEV(1)/ FVC (81.4 +/- 17.2% in females versus 87.0 +/- 12.9% in males, p = 0.009) and significantly greater bronchodilator responsiveness (expressed as percentage of baseline FEV(1)) (7.7 +/- 9.4% pred in females versus 4.1 +/- 6.4% pred in males, p = 0.002). Female smoking first-degree relatives were significantly more likely to demonstrate profound reductions in FEV(1) (< 40% pred) than male smoking first-degree relatives (p = 0. 03). Multivariate analysis, performed with generalized estimating equations, demonstrated that current or ex-smoking female first-degree relatives had significantly greater risk of FEV(1) < 80% pred (OR 1.91, 95% CI 1.03- 3.54), FEV(1) < 40% pred (OR 3.56, 95% CI 1.08-11.71), and bronchodilator response greater than 10% of baseline FEV(1) (OR 4.74, 95% CI 1.91-11.75). These results suggest that women may be more susceptible to the development of severe COPD.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1164/ajrccm.162.6.2003112

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 31 references

Cited by

See all 302

Metadata

Authors
SILVERMAN, E. K., WEISS, S. T., DRAZEN, J. M., CHAPMAN, H. A., CAREY, V., CAMPBELL, E. J., DENISH, P., SILVERMAN, R. A., CELEDON, J. C., REILLY, J. J., GINNS, L. C., & SPEIZER, F. E.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2000-12-01
Volume
162
Issue
6
Pages
2152-2158
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/ajrccm.162.6.2003112
OpenAlex
W1983387970
Cited by
302
References
31
FWCI
6.58
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Gender-Related Differences in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. https://app.cochat.ai/papers/10.1164/ajrccm.162.6.2003112
The paper
SILVERMAN, E. K., WEISS, S. T., DRAZEN, J. M., CHAPMAN, H. A., CAREY, V., CAMPBELL, E. J., DENISH, P., SILVERMAN, R. A., CELEDON, J. C., REILLY, J. J., GINNS, L. C., & SPEIZER, F. E. (2000). Gender-Related Differences in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.162.6.2003112

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.