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Cited by 330

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Quality-adjusted Survival in the First Year after the Acute Respiratory Distress Syndrome

ANGUS, DEREK C., MUSTHAFA, AMJAD A., CLERMONT, GILLES, GRIFFIN, MARTIN F., LINDE-ZWIRBLE, WALTER T., DREMSIZOV, TONY T., PINSKY, MICHAEL R.·2001·American Journal of Respiratory and Critical Care Medicine

Abstract

There is little information on long-term outcome after acute respiratory distress syndrome (ARDS). We measured quality-adjusted survival in the first year after ARDS in a prospective cohort (n = 200). All patients met traditional criteria for ARDS. Patients with sepsis and acute nonpulmonary organ dysfunction at presentation were excluded. The cohort was healthy before onset of ARDS as evidenced by high functional status (mean Karnofsky Performance Status index: 82.2/100 where >/= 80 = able to perform normal activities independently) and minimal comorbid illness (mean Charlson-Deyo comorbidity score: 0.32/17 where 0 = absence of chronic illness). We determined quality-adjusted life-years (QALYs) using the Quality of Well-being (QWB) scale (0 to 1 scale where 1 = optimal well-being), measured at 6 and 12 mo. Survival was 69.5 +/- 5.0% at 1 month, fell to 55.7 +/- 3.7% at 6 mo, and did not change at 12 mo, yielding a survival of 59 life-years in the first year per 100 patients with ARDS. QWB was low at 6 and 12 mo (0.59 +/- 0.015 and 0.60 +/- 0.015), yielding a quality-adjusted survival of 36 QALYs per 100 patients (sensitivity range: 21 to 46 QALYs). We conclude that ARDS developing in previously healthy patients is associated with poor quality-adjusted survival. These data are important for cost-effectiveness analyses and long-term care.

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Metadata

Authors
ANGUS, D. C., MUSTHAFA, A. A., CLERMONT, G., GRIFFIN, M. F., LINDE-ZWIRBLE, W. T., DREMSIZOV, T. T., & PINSKY, M. R.
Venue
American Journal of Respiratory and Critical Care Medicine
Published
2001-05-01
Volume
163
Issue
6
Pages
1389-1394
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
OpenAlex
W2022728767
Cited by
330
References
5
FWCI
15.17
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Quality-adjusted Survival in the First Year after the Acute Respiratory Distress Syndrome. https://app.cochat.ai/papers/10.1164/ajrccm.163.6.2005123
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ANGUS, D. C., MUSTHAFA, A. A., CLERMONT, G., GRIFFIN, M. F., LINDE-ZWIRBLE, W. T., DREMSIZOV, T. T., & PINSKY, M. R. (2001). Quality-adjusted Survival in the First Year after the Acute Respiratory Distress Syndrome. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.163.6.2005123

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