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Cited by 2,387

The DOI matches its Crossref record; 237 of the 237 references it cites were found in a registry or an index.

Acute respiratory distress syndrome

Open access
Matthay, Michael A., Zemans, Rachel L., Zimmerman, Guy A., Arabi, Yaseen M., Beitler, Jeremy R., Mercat, Alain, Herridge, Margaret, Randolph, Adrienne G., Calfee, Carolyn S.·2019·Nature Reviews Disease Primers
DOI 10.1038/s41572-019-0069-0
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Abstract

The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema, hypoxaemia and the need for mechanical ventilation. ARDS occurs most often in the setting of pneumonia, sepsis, aspiration of gastric contents or severe trauma and is present in ~10% of all patients in intensive care units worldwide. Despite some improvements, mortality remains high at 30–40% in most studies. Pathological specimens from patients with ARDS frequently reveal diffuse alveolar damage, and laboratory studies have demonstrated both alveolar epithelial and lung endothelial injury, resulting in accumulation of protein-rich inflammatory oedematous fluid in the alveolar space. Diagnosis is based on consensus syndromic criteria, with modifications for under-resourced settings and in paediatric patients. Treatment focuses on lung-protective ventilation; no specific pharmacotherapies have been identified. Long-term outcomes of patients with ARDS are increasingly recognized as important research targets, as many patients survive ARDS only to have ongoing functional and/or psychological sequelae. Future directions include efforts to facilitate earlier recognition of ARDS, identifying responsive subsets of patients and ongoing efforts to understand fundamental mechanisms of lung injury to design specific treatments.Acute respiratory distress syndrome (ARDS) is the rapid onset of noncardiogenic pulmonary oedema, hypoxaemia and the need for mechanical ventilation in hospitalized patients. This Primer describes the risk factors for ARDS, the underlying pulmonary damage and repair in ARDS and the long-term consequences for survivors.

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Metadata

Authors
Matthay, M. A., Zemans, R. L., Zimmerman, G. A., Arabi, Y. M., Beitler, J. R., Mercat, A., Herridge, M., Randolph, A. G., & Calfee, C. S.
Venue
Nature Reviews Disease Primers
Publisher
Springer Science and Business Media LLC
Published
2019-03-14
Volume
5
Issue
1
Pages
18-18
ISSN
2056-676X (ISSN-L)
DOI
10.1038/s41572-019-0069-0
OpenAlex
W4211250103
Cited by
2,387
References
237
FWCI
57.60
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Acute respiratory distress syndrome. https://app.cochat.ai/papers/10.1038/s41572-019-0069-0
The paper
Matthay, M. A., Zemans, R. L., Zimmerman, G. A., Arabi, Y. M., Beitler, J. R., Mercat, A., Herridge, M., Randolph, A. G., & Calfee, C. S. (2019). Acute respiratory distress syndrome. Nature Reviews Disease Primers. https://doi.org/10.1038/s41572-019-0069-0

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.