The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inhaled Corticosteroids Reduce the Severity of Bronchial Hyperresponsiveness in Asthma, But Oral Theophylline Does Not
Abstract
In a double-blind crossover study, we compared the relative effects of inhaled beclomethasone dipropionate (BDP) 800 micrograms per day and oral theophylline on the severity of bronchial hyperresponsiveness (BHR) to histamine. Daily doses of theophylline were sufficient to keep serum levels between 55 and 110 mumol/L. The subjects were 26 patients with severe asthma whose symptoms were inadequately controlled by regular treatment with inhaled salbutamol. The severity of BHR improved within 3 wk in the group treated with BDP, whereas no change occurred in the group treated with theophylline. There were no significant changes in FEV1 in either group during the study. When BDP was changed to theophylline there was a deterioration in BHR. Aerosol steroids, rather than theophylline, are the treatment of choice when reduction in the severity of BHR is the aim of treatment in patients with severe asthma.
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Citations
Cites
Rapid method for measurement of bronchial responsiveness.
Yan, K., Salome, C., & Woolcock, A. J. (1983) · Thorax · doi:10.1136/thx.38.10.760 · Cited by 758
Self-citation
Cited by
Haahtela, T., Järvinen, M., Kava, T., Kiviranta, K., Koskinen, S., Lehtonen, K., Nikander, K., Persson, T., Reinikainen, K., Selroos, O., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199108083250603 · Cited by 785
A New Approach to the Treatment of Asthma
Oates, J. A., Wood, A. J. J., & Barnes, P. J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198911303212206 · Cited by 450
The assessment and treatment of asthma: A conference report
Hargreave, F. E., Dolovich, J., & Newhouse, M. T. (1990) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(90)90056-a · Cited by 377
Woolcock, A., Seale, J. P., Rubinfeld, A. R., Landau, L. L., Antic, R., Mitchell, C., Rea, H. H., & Zimmerman, P. (1989) · Medical Journal of Australia · doi:10.5694/j.1326-5377.1989.tb139640.x · Cited by 280
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Metadata
- Authors
- DuToit, J. I., Salome, C. M., & Woolcock, A. J.
- Venue
- American Review of Respiratory Disease
- Publisher
- Oxford University Press (OUP)
- Published
- 1987-11
- Volume
- 136
- Issue
- 5
- Pages
- 1174-1178
- ISSN
- 0003-0805 (ISSN-L)
- OpenAlex
- W2027387346
- Cited by
- 213
- References
- 1
- FWCI
- 15.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- DuToit, J. I., Salome, C. M., & Woolcock, A. J. (1987). Inhaled Corticosteroids Reduce the Severity of Bronchial Hyperresponsiveness in Asthma, But Oral Theophylline Does Not. American Review of Respiratory Disease. https://doi.org/10.1164/ajrccm/136.5.1174
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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