The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Comparison of a β2-Agonist, Terbutaline, with an Inhaled Corticosteroid, Budesonide, in Newly Detected Asthma
Open accessAbstract
BACKGROUND: The presence of airway inflammation even in mild asthma points to the potential value of antiinflammatory therapy. We compared the effect of an inhaled corticosteroid, budesonide, with that of an inhaled beta 2-agonist, terbutaline, in the long-term treatment of newly detected asthma. METHODS: We studied 103 patients (29 male and 74 female patients 15 to 64 years old) in whom asthma had appeared within the previous year. The patients were randomly assigned in blinded fashion to two treatment groups: one to receive 600 micrograms of inhaled budesonide twice a day, and the other to receive 375 micrograms of inhaled terbutaline twice a day. The study period was two years. RESULTS: After six weeks of treatment, the patients treated with budesonide tolerated inhaled histamine better than the patients treated with terbutaline (a difference of one doubling dose step, P less than 0.001), and the difference was sustained. Patients' diaries kept during the first three months of the study and during the last month of the first and second years showed budesonide to be more effective than terbutaline in improving peak expiratory flow in the morning (average increase from the pretreatment value, 32.8 liters per minute for budesonide vs. 4.8 liters per minute for terbutaline; P less than 0.001) and in the evening (P less than 0.01). Budesonide was also more effective in reducing the symptoms of asthma (P less than 0.01) and the use of supplemental beta 2-agonist medication (P less than 0.01). Ten patients were withdrawn from the terbutaline group because treatment was insufficiently effective, whereas only one dropped out of the budesonide group. The adverse reactions to both treatments were few and mild. CONCLUSIONS: Antiinflammatory therapy with inhaled budesonide is an effective first-line treatment for patients with newly detected, mild asthma, and it is superior to the use of terbutaline in such patients.
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Cites
Damage of the Airway Epithelium and Bronchial Reactivity in Patients with Asthma
Laitinen, L. A., Heino, M., Laitinen, A., Kava, T., & Haahtela, T. (1985) · American Review of Respiratory Disease · doi:10.1164/arrd.1985.131.4.599 · Cited by 1,280
Self-citationRegular inhaled beta-agonist treatment in bronchial asthma
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REBOUND INCREASE IN BRONCHIAL RESPONSIVENESS AFTER TREATMENT WITH INHALED TERBUTALINE
Vathenen, A. S., Higgins, B. G., Knox, A. J., Britton, J. R., & Tattersfield, A. E. (1988) · The Lancet · doi:10.1016/s0140-6736(88)91352-9 · Cited by 333
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Spirometric Studies in Non-Smoking, Healthy Adults
Viljanen, A. A., Halttunen, P. K., Kreus, K.-E., & Viljanen, B. C. (1982) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365518209168377 · Cited by 237
DuToit, J. I., Salome, C. M., & Woolcock, A. J. (1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.5.1174 · Cited by 213
Peak Expiratory Flow in Normal Subjects
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Cited by
Asthma: From Bronchoconstriction to Airways Inflammation and Remodeling
BOUSQUET, J., JEFFERY, P. K., BUSSE, W. W., JOHNSON, M., & VIGNOLA, A. M. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.5.9903102 · Cited by 1,702
Effect of Inhaled Formoterol and Budesonide on Exacerbations of Asthma
Pauwels, R. A., Löfdahl, C.-G., Postma, D. S., Tattersfield, A. E., O'Byrne, P., Barnes, P. J., & Ullman, A. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711133372001 · Cited by 1,520
A 15-year follow-up study of ventilatory function in adults with asthma
Lange, P., Parner, J., Vestbo, J., Schnohr, P., & Jensen, G. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810223391703 · Cited by 1,250
Intermittent Inhaled Corticosteroids in Infants with Episodic Wheezing
Bisgaard, H., Hermansen, M. N., Loland, L., Halkjaer, L. B., & Buchvald, F. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054692 · Cited by 560
ISRAEL, E., DRAZEN, J. M., LIGGETT, S. B., BOUSHEY, H. A., CHERNIACK, R. M., CHINCHILLI, V. M., COOPER, D. M., FAHY, J. V., FISH, J. E., FORD, J. G., et al. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.1.9907092 · Cited by 549
Metadata
- Authors
- Haahtela, T., Järvinen, M., Kava, T., Kiviranta, K., Koskinen, S., Lehtonen, K., Nikander, K., Persson, T., Reinikainen, K., Selroos, O., Sovijärvi, A., Stenius-Aarniala, B., Svahn, T., Tammivaara, R., & Laitinen, L. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1991-08-08
- Volume
- 325
- Issue
- 6
- Pages
- 388-392
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2331642892
- Cited by
- 785
- References
- 12
- FWCI
- 26.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Haahtela, T., Järvinen, M., Kava, T., Kiviranta, K., Koskinen, S., Lehtonen, K., Nikander, K., Persson, T., Reinikainen, K., Selroos, O., Sovijärvi, A., Stenius-Aarniala, B., Svahn, T., Tammivaara, R., & Laitinen, L. A. (1991). Comparison of a β2-Agonist, Terbutaline, with an Inhaled Corticosteroid, Budesonide, in Newly Detected Asthma. New England Journal of Medicine. https://doi.org/10.1056/nejm199108083250603
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
