Rapid method for measurement of bronchial responsiveness.
Open accessAbstract
A rapid, simple method for measuring bronchial responsiveness to inhaled histamine is described. The method was used to obtain dose response curves in 50 atopic subjects with varying respiratory and nasal symptoms. The cumulative dose of histamine which caused a 20% fall in the one second forced expiratory volume (PD20-FEV1) varied between 0.046 and greater than 3.9 mumol and correlated with the severity of symptoms. The reproducibility of the PD20-FEV1, determined from duplicate measurements in 15 subjects with varying degrees of bronchial responsiveness was found to be satisfactory. When the PD20-FEV1 from this rapid method was compared with that obtained from the dosimeter method no significant difference was found. The dose delivered by this method was shown to be cumulative.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bronchial reactivity to inhaled histamine: a method and clinical survey
Cockcroft, D. W., Killian, D. N., MELLON, J. J. A., & Hargreave, F. E. (1977) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1977.tb01448.x · Cited by 1,838 · see citing works
Standardization of bronchial inhalation challenge procedures
Chai, H., Farr, R. S., Froehlich, L. A., Mathison, D. A., McLean, J. A., Rosenthal, R. R., Sheffer, A. L., Spector, S. L., & Townley, R. G. (1975) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(75)90107-4 · Cited by 1,452 · see citing works
RYAN, G. F., DOLOVICH, M. B., Roberts, R. S., et al. (1981) · PubMed · doi:10.1164/arrd.1981.123.2.195 · Cited by 205 · see citing works
Bronchial responsiveness as a function of inhaled histamine and the methods of measurement.
Neijens, H. J., Hofkamp, M., DEGENHART, H. J., et al. (1982) · PubMed · Cited by 23 · see citing works
Comparison of histamine bronchial challenges with the Wright nebulizer and the dosimeter
Beaupré, A., & Malo, J. (1979) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1979.tb00482.x · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sporik, R., Holgate, S. T., Platts-Mills, T. A. E., & Cogswell, J. J. (1990) · New England Journal of Medicine · doi:10.1056/nejm199008233230802 · Cited by 1,648 · see citing works
O'Hollaren, M. T., Yunginger, J. W., Offord, K. P., Somers, M. J., O'Connell, E. J., Ballard, D. J., & Sachs, M. I. (1991) · New England Journal of Medicine · doi:10.1056/nejm199102073240602 · Cited by 694 · see citing works
A daily SMS reminder increases adherence to asthma treatment: A three-month follow-up study
Strandbygaard, U., Thomsen, S. F., & Backer, V. (2010) · Respiratory Medicine · doi:10.1016/j.rmed.2009.10.003 · Cited by 295 · see citing works
Occupational asthma caused by chloramines in indoor swimming-pool air
Thickett, K. M., McCoach, J. S., Gerber, J. M., Sadhra, S., & Burge, P. S. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00232802 · Cited by 266 · see citing works
Exposure to house dust mite allergens and the clinical activity of asthma
Custovic, A., Taggart, S. C. O., Francis, H. C., Chapman, M. D., & Woodcock, A. (1996) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(96)70227-0 · Cited by 251 · see citing works
Rhodes, H. L., Thomas, P., Sporik, R., Holgate, S. T., & Cogswell, J. J. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.2.2104032 · Cited by 229 · see citing works
Clinical Importance of <i>Alternaria</i> Exposure in Children
DOWNS, S. H., MITAKAKIS, T. Z., MARKS, G. B., CAR, N. G., BELOUSOVA, E. G., LEÜPPI, J. D., XUAN, W., DOWNIE, S. R., TOBIAS, A., & PEAT, J. K. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.3.2008042 · Cited by 202 · see citing works
Langley, S. J., Goldthorpe, S., Craven, M., Morris, J., Woodcock, A., & Custovic, A. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1654 · Cited by 171 · see citing works
Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders
Moller-Larsen, S., Nyegaard, M., Haagerup, A., Vestbo, J., Kruse, T. A., & Borglum, A. D. (2008) · Thorax · doi:10.1136/thx.2007.094128 · Cited by 154 · see citing works
Font-Ribera, L., Villanueva, C. M., Nieuwenhuijsen, M. J., Zock, J.-P., Kogevinas, M., & Henderson, J. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201005-0761oc · Cited by 117 · see citing works
Langley, S. J. (2005) · Thorax · doi:10.1136/thx.2004.027839 · Cited by 74 · see citing works
Langley, S. J., Goldthorpe, S., Custovic, A., & Woodcock, A. (2003) · Annals of Allergy, Asthma & Immunology · doi:10.1016/s1081-1206(10)61688-2 · Cited by 71 · see citing works
Do grandmaternal smoking patterns influence the etiology of childhood asthma?
Miller, L. L., Henderson, J., Northstone, K., Pembrey, M., & Golding, J. (2014) · Chest · doi:10.1378/chest.13-1371 · Cited by 67 · see citing works
Omland, Ø., Hjort, C., Pedersen, O. F., Miller, M. R., & Sigsgaard, T. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.06.006 · Cited by 61 · see citing works
- Authors
- Yan, K., Salome, C., & Woolcock, A. J.
- Affiliations
- The University of Sydney (AU)
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 1983-10-01
- Volume
- 38
- Issue
- 10
- Pages
- 760-765
- ISSN
- 0040-6376 (ISSN-L)
- PMC
- PMC459653
- OpenAlex
- W2106245415
- Cited by
- 758
- References
- 5
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 8 · 2017: 4 · 2016: 5 · 2015: 13 · 2014: 14 · 2013: 11 · 2012: 16
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Thorax (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- airway responsiveness, histamine challenge, atopy, dose-response curves, forced expiratory volume, reproducibility, cumulative dose, respiratory symptoms, nasal symptoms
- MeSH terms
- Adolescent, Adult, Bronchial Provocation Tests, Dose-Response Relationship, Drug, Female, Forced Expiratory Volume, Histamine, Humans, Male, Middle Aged, Respiratory Hypersensitivity, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
