The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Urinary Excretion of Leukotriene E 4 and 11-dehydro-Thromboxane B 2 in Response to Bronchial Provocations with Allergen, Aspirin, Leukotriene D 4 , and Histamine in Asthmatics
Abstract
In vivo production of thromboxane (TX) A2 and the cysteinyl-containing leukotrienes (LT) C4, D4, and E4 in correlation to airway responses was studied. Bronchial provocation with specific allergen in atopic asthmatics was followed by a significant increase in urinary concentration of immunoreactive LTE4 (34 +/- 6 before versus 56 +/- 7 ng/mmol creatinine after allergen challenge; n = 5) and 11-dehydro-TXB2 (164 +/- 29 versus 238 +/- 25 ng/mmol creatinine). In the presence of the leukotriene-antagonist ICI-204,219, which significantly increased the PD20 for allergen, the increment in urinary excretion of LTE4 was even higher (60 +/- 8 versus 288 +/- 128 ng/mmol creatinine; n = 5). In contrast, provocation with histamine (n = 5) did not provoke release of leukotrienes or thromboxane, nor was inhalation of LTD4 (n = 7) associated with increased urinary concentration of 11-dehydro-TXB2. Furthermore, bronchoconstriction induced by inhalation of lysine-aspirin in aspirin-sensitive asthmatics (n = 4) was followed by increased levels of LTE4 in the urine, whereas the levels of 11-dehydro-TXB2 remained the same. Finally, the basal levels of LTE4 in the urine of nine aspirin-sensitive asthmatics were elevated as compared with 15 other asthmatics (112 +/- 54 versus 38 +/- 20 ng/mmol creatinine; p less than 0.001). The findings support that the cysteinyl-leukotrienes are potential mediators of allergen-induced asthma and that the release of LTE4 and 11-dehydro-TXB2 into the urine appeared to be a direct and dose-dependent effect of the antigen-antibody reaction.(ABSTRACT TRUNCATED AT 250 WORDS)
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Christie, P. E., Tagari, P., Ford-Hutchinson, A. W., Charlesson, S., Chee, P., Arm, J. P., & Lee, T. H. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/143.5_pt_1.1025 · Cited by 449
Taylor, I. K., O'Shaughnessy, K. M., Fuller, R. W., & Dollery, C. (1991) · The Lancet · doi:10.1016/0140-6736(91)90277-v · Cited by 433
Dahlén, S. E., Hansson, G., Hedqvist, P., Björck, T., Granström, E., & Dahlén, B. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.6.1712 · Cited by 415
Self-citationURINARY LEUKOTRIENE E4 AFTER ANTIGEN CHALLENGE AND IN ACUTE ASTHMA AND ALLERGIC RHINITIS
Taylor, G., Black, P., Turner, N., Taylor, I., Maltby, N., Fuller, R., & Dollery, C. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91611-5 · Cited by 339
Metabolism of thromboxane B2 in man. Identification of twenty urinary metabolites.
Roberts, L. J., Sweetman, B. J., & Oates, J. A. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68855-1 · Cited by 246
Ferreri, N. R., Howland, W. C., Stevenson, D. D., & Spiegelberg, H. L. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/137.4.847 · Cited by 216
Airway Responsiveness to Histamine and Leukotriene E 4 in Subjects with Aspirin-induced Asthma
Arm, J. P., O'hickey, S. P., Spur, B. W., & Lee, T. H. (1989) · American Review of Respiratory Disease · doi:10.1164/ajrccm/140.1.148 · Cited by 179
Weiss, J. W. (1983) · JAMA · doi:10.1001/jama.249.20.2814 · Cited by 167
Allergen-stimulated Release of Thromboxane A2 and Leukotriene E4 in Humans: Effect of Indomethacin
Sładek, K., Dworski, R., FitzGerald, G. A., et al. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.6.1441 · Cited by 139
Jones, T. R., Davis, C., & Daniel, E. E. (1982) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y82-087 · Cited by 134
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Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
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DAHLÉN, B., NIZANKOWSKA, E., SZCZEKLIK, A., ZETTERSTRÖM, O., BOCHENEK, G., KUMLIN, M., MASTALERZ, L., PINIS, G., SWANSON, L. J., BOODHOO, T. I., et al. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.4.9707089 · Cited by 396
Self-citationIsrael, E., Fischer, A. R., Rosenberg, M. A., Lilly, C. M., Callery, J. C., Shapiro, J., Cohn, J., Rubin, P., & Drazen, J. M. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/148.6_pt_1.1447 · Cited by 377
Aspirin-induced asthma: Advances in pathogenesis and management
Szczeklik, A., & Stevenson, D. D. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70106-5 · Cited by 323
Metadata
- Authors
- Kumlin, M., Dahlén, B., Björck, T., Zetterström, O., Granström, E., & Dahlén, S.-E.
- Venue
- American Review of Respiratory Disease
- Publisher
- Oxford University Press (OUP)
- Published
- 1992-07
- Volume
- 146
- Issue
- 1
- Pages
- 96-103
- ISSN
- 0003-0805 (ISSN-L)
- OpenAlex
- W2017485498
- Cited by
- 289
- References
- 16
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Urinary Excretion of Leukotriene E 4 and 11-dehydro-Thromboxane B 2 in Response to Bronchial Provocations with Allergen, Aspirin, Leukotriene D 4 , and Histamine in Asthmatics. https://app.cochat.ai/papers/10.1164/ajrccm/146.1.96
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- Kumlin, M., Dahlén, B., Björck, T., Zetterström, O., Granström, E., & Dahlén, S.-E. (1992). Urinary Excretion of Leukotriene E 4 and 11-dehydro-Thromboxane B 2 in Response to Bronchial Provocations with Allergen, Aspirin, Leukotriene D 4 , and Histamine in Asthmatics. American Review of Respiratory Disease. https://doi.org/10.1164/ajrccm/146.1.96
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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