The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Interferon-γ and Interleukin-10 Gene Polymorphisms in Pulmonary Tuberculosis
Abstract
Several genes coding for different cytokines may affect host susceptibility to tuberculosis. This study investigates the relationship of the single base change polymorphic variants identified in the first intron of interferon-gamma (+874 T/A) and in the promoter region of interleukin-10 gene (-1,082 G/A), with cytokine production by peripheral blood mononuclear cells and tuberculosis susceptibility. We studied a Spanish population of 113 patients with culture-proven pulmonary tuberculosis, 207 healthy close contacts (125 tuberculin reactive and 82 tuberculin negative), and 100 healthy tuberculin-negative control subjects. Multiple logistic regression analysis showed that individuals homozygous for the interferon-gamma (+874) A allele had a 3.75-fold increased risk of developing tuberculosis (95% confidence interval, 2.26-6.23, p = 0.0017). Stimulated production of interferon-gamma by peripheral mononuclear cells from patients with genotype AA was depressed compared with that of non-AA homozygotes at the time of diagnosis and after completion of therapy. Multivariate analysis showed that the presence of an AA genotype and the absolute number of lymphocytes were the only independent predictors of interferon-gamma production. In contrast, the different rates of interleukin-10 production associated with the interleukin-10 polymorphism did not affect susceptibility to tuberculosis. Thus, a genetic defect in the production of interferon-gamma in individuals homozygous for the (+874) A allele could contribute to their increased risk of developing tuberculosis.
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Cites
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
Flynn, J. L., Chan, J., Triebold, K. J., Dalton, D. K., Stewart, T. A., & Bloom, B. R. (1993) · The Journal of experimental medicine · doi:10.1084/jem.178.6.2249 · Cited by 2,465
AN INVESTIGATION OF POLYMORPHISM IN THE INTERLEUKIN‐10 GENE PROMOTER
Turner, D. M., Williams, D. M., Sankaran, D., Lazarus, M., Sinnott, P. J., & Hutchinson, I. V. (1997) · European Journal of Immunogenetics · doi:10.1111/j.1365-2370.1997.tb00001.x · Cited by 1,717
Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL
Heinemeyer, T. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.1.362 · Cited by 1,451
A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection
Newport, M. J., Huxley, C. M., Huston, S., Hawrylowicz, C. M., Oostra, B. A., Williamson, R., & Levin, M. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612263352602 · Cited by 1,199
Interferon-γ –Receptor Deficiency in an Infant with Fatal Bacille Calmette–Guérin Infection
Jouanguy, E., Altare, F., Lamhamedi, S., Revy, P., Emile, J.-F., Newport, M., Levin, M., Blanche, S., Seboun, E., Fischer, A., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612263352604 · Cited by 895
Variations in the NRAMP1 Gene and Susceptibility to Tuberculosis in West Africans
Bellamy, R., Ruwende, C., Corrah, T., McAdam, K. P. W. J., Whittle, H. C., & Hill, A. V. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803053381002 · Cited by 735
A single nucleotide polymorphism in the first intron of the human IFN-γ gene:
Pravica, V., Perrey, C., Stevens, A., Lee, J.-H., & Hutchinson, I. V. (2000) · Human Immunology · doi:10.1016/s0198-8859(00)00167-1 · Cited by 616
THE IMMUNOGENETICS OF HUMAN INFECTIOUS DISEASES
Hill, A. V. S. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.593 · Cited by 581
Pravica, V., Asderakis, A., Perrey, C., Hajeer, A., Sinnott, P. J., & Hutchinson, I. V. (1999) · European Journal of Immunogenetics · doi:10.1046/j.1365-2370.1999.00122.x · Cited by 455
Bellamy, R., Ruwende, C., Corrah, T., McAdam, K. P. W. J., Thursz, M., Whittle, H. C., & Hill, A. V. S. (1999) · The Journal of Infectious Diseases · doi:10.1086/314614 · Cited by 436
Cited by
The role of IL-10 in immune regulation during M. tuberculosis infection
Redford, P. S., Murray, P. J., & O'Garra, A. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.7 · Cited by 472
The two faces of interleukin 10 in human infectious diseases
Mege, J.-L., Meghari, S., Honstettre, A., Capo, C., & Raoult, D. (2006) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(06)70577-1 · Cited by 257
Metadata
- Authors
- López-Maderuelo, D., Arnalich, F., Serantes, R., González, A., Codoceo, R., Madero, R., Vázquez, J. J., & Montiel, C.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-04-01
- Volume
- 167
- Issue
- 7
- Pages
- 970-975
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2152906249
- Cited by
- 256
- References
- 26
- FWCI
- 11.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- López-Maderuelo, D., Arnalich, F., Serantes, R., González, A., Codoceo, R., Madero, R., Vázquez, J. J., & Montiel, C. (2003). Interferon-γ and Interleukin-10 Gene Polymorphisms in Pulmonary Tuberculosis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200205-438bc
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