The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.
Acute Severe Asthma
Abstract
Acute severe asthma remains a major economic and health burden. The natural history of acute decompensations is one of resolution and only about 0.4% of patients succumb overall. Mortality in medical intensive care units is higher but is less than 3% of hospital admissions. "Near-fatal" episodes may be more frequent, but precise figures are lacking. However, about 30% of medical intensive care unit admissions require intubation and mechanical ventilation with mortality of 8%. Morbidity and mortality increase with socioeconomic deprivation and ethnicity. Seventy to 80% of patients in emergency departments clear within 2 hours with standardized care. The relapse rate varies between 7 and 15%, depending on how aggressively the patient is treated. The airway obstruction in the 20-30% of people resistant to adrenergic agonists in the emergency department slowly reverses over 36-48 hours but requires intense treatment to do so. Current therapeutic options for this group consist of ipratropium and corticosteroids in combination with beta2 selective drugs. Even so, such regimens are not optimal and better approaches are needed. The long-term prognosis after a near-fatal episode is poor and mortality may approach 10%.
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Cites
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Cited by
Vanden Hoek, T. L., Morrison, L. J., Shuster, M., Donnino, M., Sinz, E., Lavonas, E. J., Jeejeebhoy, F. M., & Gabrielli, A. (2010) · Circulation · doi:10.1161/circulationaha.110.971069 · Cited by 720
Kenyon, N. J., Bratt, J. M., Lee, J., Luo, J., Franzi, L. M., Zeki, A. A., & Lam, K. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077730 · Cited by 53
Metadata
- Authors
- McFadden, E. R.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-10-01
- Volume
- 168
- Issue
- 7
- Pages
- 740-759
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2145569721
- Cited by
- 317
- References
- 161
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
