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Cited by 260

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Exercise-induced Quadriceps Oxidative Stress and Peripheral Muscle Dysfunction in Patients with Chronic Obstructive Pulmonary Disease

Couillard, Annabelle, Maltais, François, Saey, Didier, Debigaré, Richard, Michaud, Annie, Koechlin, Christelle, LeBlanc, Pierre, Préfaut, Christian·2003·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.200209-1028oc
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Abstract

Exercise-induced muscle oxidative stress may be involved in the myopathy associated with chronic obstructive pulmonary disease (COPD). This study was designed to look at whether local exercise induces muscle oxidative stress and whether this oxidative stress may be associated with the reduced muscle endurance in patients with COPD. Quadriceps endurance was measured in 12 patients with COPD (FEV1 = 0.96 +/- 0.14 SEM) and 10 healthy sedentary subjects by repeated knee extensions of the dominant leg. Biopsies of the vastus lateralis muscle were obtained before and 48 hours after exercise. Muscle oxidative stress was measured by lipid peroxidation and oxidized proteins. Muscle antioxidant was evaluated by peroxidase glutathion activity. Quadriceps endurance was significantly reduced in patients with COPD when compared with the healthy control subjects (p < 0.01). Forty-eight hours postexercise, only patients with COPD had a significant increase in muscle lipid peroxidation (p < 0.05) and oxidized proteins (p < 0.05), whereas increased peroxidase glutathion activity was only observed in control subjects (p < 0.05). Both increases in muscle lipid peroxidation and oxidized proteins were significantly and inversely correlated with quadriceps endurance capacity in COPD (p < 0.05). In summary, local exercise induced muscle oxidative stress in patients with COPD, whereas it failed to raise antioxidant activity. In these individuals, muscle oxidative stress was associated with a reduced quadriceps endurance.

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Metadata

Authors
Couillard, A., Maltais, F., Saey, D., Debigaré, R., Michaud, A., Koechlin, C., LeBlanc, P., & Préfaut, C.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2003-06-15
Volume
167
Issue
12
Pages
1664-1669
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.200209-1028oc
OpenAlex
W1988481400
Cited by
260
References
40
FWCI
18.21
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Exercise-induced Quadriceps Oxidative Stress and Peripheral Muscle Dysfunction in Patients with Chronic Obstructive Pulmonary Disease. https://app.cochat.ai/papers/10.1164/rccm.200209-1028oc
The paper
Couillard, A., Maltais, F., Saey, D., Debigaré, R., Michaud, A., Koechlin, C., LeBlanc, P., & Préfaut, C. (2003). Exercise-induced Quadriceps Oxidative Stress and Peripheral Muscle Dysfunction in Patients with Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200209-1028oc

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.