Peripheral Muscle Weakness in Patients with Chronic Obstructive Pulmonary Disease
Abstract
Peripheral muscle weakness is commonly found in patients with chronic obstructive pulmonary disease (COPD) and may play a role in reducing exercise capacity. The purposes of this study were to evaluate, in patients with COPD: (1) the relationship between muscle strength and cross-sectional area (CSA), (2) the distribution of peripheral muscle weakness, and (3) the relationship between muscle strength and the severity of lung disease. Thirty-four patients with COPD and 16 normal subjects of similar age and body mass index were evaluated. Compared with normal subjects, the strength of three muscle groups (p < 0.05) and the right thigh muscle CSA, evaluated by computed tomography (83.4 +/- 16.4 versus 109.6 +/- 15.6 cm2, p < 0.0001), were reduced in COPD. The quadriceps strength/thigh muscle CSA ratio was similar for the two groups. The reduction in quadriceps strength was proportionally greater than that of the shoulder girdle muscles (p < 0.05). Similar observations were made whether or not patients had been exposed to systemic corticosteroids in the 6-mo period preceding the study, although there was a tendency for the quadriceps strength/thigh muscle CSA ratio to be lower in patients who had received corticosteroids. In COPD, quadriceps strength and muscle CSA correlated positively with the FEV1 expressed in percentage of predicted value (r = 0.55 and r = 0. 66, respectively, p < 0.0005). In summary, the strength/muscle cross-sectional area ratio was not different between th…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Structural alterations of peripheral skeletal muscle in COPD include a global muscle atrophy with loss in number and size of muscle fibers, reflected by decreased thigh diameter and decreased fibers' cross-sectional area.
“Structural alterations of peripheral skeletal muscle are well characterized and include a global muscle atrophy (with both loss in number and size of muscle fibers), macroscopically reflected by a decrease in thigh diameter [11] and microscopically reflected by a decreased fibers’ cross-sectional area (CSA) [12]”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [11]
Cites
Skeletal muscle density: effects of obesity and non-insulin-dependent diabetes mellitus
Kelley, D., Slasky, B., & Janosky, J. (1991) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.3.509 · Cited by 206 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Spruit, M. A., Singh, S. J., Garvey, C., ZuWallack, R., Nici, L., Rochester, C., Hill, K., Holland, A. E., Lareau, S. C., Man, W. D.-C., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201309-1634st · Cited by 3,938 · see citing works
Self-citationAmerican Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
Nici, L., Donner, C., Wouters, E., Zuwallack, R., Ambrosino, N., Bourbeau, J., Carone, M., Celli, B., Engelen, M., Fahy, B., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200508-1211st · Cited by 1,966 · see citing works
Self-citationSwallow, E. B., Reyes, D., Hopkinson, N. S., Man, W. D.-C., Porcher, R., Cetti, E. J., Moore, A. J., Moxham, J., & Polkey, M. I. (2007) · Thorax · doi:10.1136/thx.2006.062026 · Cited by 728 · see citing works
Muscle strength and body mass index as long-term predictors of mortality in initially healthy men
Rantanen, T., Harris, T., Leveille, S. G., Visser, M., Foley, D., Masaki, K., & Guralnik, J. M. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.3.m168 · Cited by 647 · see citing works
Muscle strength, disability and mortality
Rantanen, T. (2003) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1034/j.1600-0838.2003.00298.x · Cited by 317 · see citing works
Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease
Hussain, S., Cheol, K., & Mofarrahi, M. (2008) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s4480 · Cited by 224 · see citing works
Muscle Wasting and Changes in Muscle Protein Metabolism in Chronic Obstructive Pulmonary Disease
Jagoe, R. T., & Engelen, M. P. K. J. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00004608 · Cited by 134 · see citing works
Comparisons of three different methods for defining sarcopenia: an aspect of cardiometabolic risk
Kim, T. N., Park, M. S., Lee, E. J., Chung, H. S., Yoo, H. J., Kang, H. J., Song, W., Baik, S. H., & Choi, K. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-06831-7 · Cited by 86 · see citing works
Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting
Henrot, P., Dupin, I., Schilfarth, P., Esteves, P., Blervaque, L., Zysman, M., Gouzi, F., Hayot, M., Pomiès, P., & Berger, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076454 · Cited by 85 · see citing works
“Structural alterations of peripheral skeletal muscle are well characterized and include a global muscle atrophy (with both loss in number and size of muscle fibers), macroscopically reflected by a decrease in thigh diameter [11] and microscopically reflected by a decreased fibers’ cr ss-sectional area (CSA) [12] (Figu…”
BackgroundSava, F., Laviolette, L., Bernard, S., Breton, M.-J., Bourbeau, J., & Maltais, F. (2010) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-10-55 · Cited by 84 · see citing works
Self-citationLim, K. I., Yang, S. J., Kim, T. N., Yoo, H. J., Kang, H. J., Song, W., Baik, S. H., Choi, D. S., & Choi, K. M. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03841.x · Cited by 82 · see citing works
Role of Autophagy in COPD Skeletal Muscle Dysfunction
Hussain, S. N. A., & Sandri, M. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00893.2012 · Cited by 77 · see citing works
Exercise in chronic pulmonary disease: resistance exercise prescription
STORER, T. W. (2001) · Medicine and Science in Sports and Exercise · doi:10.1097/00005768-200107001-00006 · Cited by 75 · see citing works
Respiratory and Skeletal Muscles in Hypogonadal Men with Chronic Obstructive Pulmonary Disease
Laghi, F., Langbein, W. E., Antonescu-Turcu, A., Jubran, A., Bammert, C., & Tobin, M. J. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200412-1643oc · Cited by 57 · see citing works
Benton, M. J., Wagner, C. L., & Alexander, J. L. (2010) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0b013e3181d6f94f · Cited by 29 · see citing works
- Authors
- BERNARD, S., LeBLANC, P., WHITTOM, F., CARRIER, G., JOBIN, J., BELLEAU, R., & MALTAIS, F.
- Affiliations
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-08-01
- Volume
- 158
- Issue
- 2
- Pages
- 629-634
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2069141143
- Cited by
- 817
- References
- 1
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 18 · 2023: 16 · 2022: 20 · 2021: 21 · 2020: 23 · 2019: 21 · 2018: 17 · 2017: 35 · 2016: 24 · 2015: 35 · 2014: 46 · 2013: 37 · 2012: 41
- FWCI
- 17.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- chronic obstructive pulmonary disease, peripheral muscle weakness, muscle strength, muscle cross-sectional area, quadriceps strength, thigh muscle, muscle atrophy, systemic corticosteroids, FEV1, exercise capacity, muscle deconditioning
- MeSH terms
- Aged, Humans, Lung Diseases, Obstructive, Male, Middle Aged, Muscle Contraction, Thigh, Exercise Tolerance, Muscle, Skeletal, Anatomy, Cross-Sectional
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
