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Cited by 513

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Prognostic Implications of Physiologic and Radiographic Changes in Idiopathic Interstitial Pneumonia

Flaherty, Kevin R., Mumford, Jeanette A., Murray, Susan, Kazerooni, Ella A., Gross, Barry H., Colby, Thomas V., Travis, William D., Flint, Andrew, Toews, Galen B., Lynch, Joseph P., Martinez, Fernando J.·2003·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.200209-1112oc
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Abstract

Idiopathic interstitial pneumonias are a diverse group of lung diseases with varied prognoses. We hypothesized that changes in physiologic and radiographic parameters would predict survival. We retrospectively examined 80 patients with usual interstitial pneumonia and 29 patients with nonspecific interstitial pneumonia. Baseline characteristics were examined together with 6-month change in forced vital capacity, diffusing capacity for carbon monoxide, and ground glass infiltrate and fibrosis on high resolution computed tomography. Patients with usual interstitial pneumonia were more likely to have a statistically significant or marginally significant decline in lung volume, diffusing capacity for carbon monoxide, and an increase in ground glass infiltrates (p < or = 0.08) compared with patients with nonspecific interstitial pneumonia. For patients with usual interstitial pneumonia, change in forced vital capacity was the best physiologic predictor of mortality (p = 0.05). In a multivariate Cox proportional hazards model controlling for histopathologic diagnosis, gender, smoking history, baseline forced vital capacity, and 6-month change in forced vital capacity, a decrease in forced vital capacity remained an independent risk factor for mortality (decrease > 10%; hazard ratio 2.47; 95% confidence interval 1.29, 4.73; p = 0.006). We conclude that a 6-month change in forced vital capacity gives additional prognostic information to baseline features for patients with idiopathic interstitial pneumonia.

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Metadata

Authors
Flaherty, K. R., Mumford, J. A., Murray, S., Kazerooni, E. A., Gross, B. H., Colby, T. V., Travis, W. D., Flint, A., Toews, G. B., Lynch, J. P., & Martinez, F. J.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2003-09-01
Volume
168
Issue
5
Pages
543-548
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.200209-1112oc
OpenAlex
W2139890009
Cited by
513
References
38
FWCI
19.83
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Prognostic Implications of Physiologic and Radiographic Changes in Idiopathic Interstitial Pneumonia. https://app.cochat.ai/papers/10.1164/rccm.200209-1112oc
The paper
Flaherty, K. R., Mumford, J. A., Murray, S., Kazerooni, E. A., Gross, B. H., Colby, T. V., Travis, W. D., Flint, A., Toews, G. B., Lynch, J. P., & Martinez, F. J. (2003). Prognostic Implications of Physiologic and Radiographic Changes in Idiopathic Interstitial Pneumonia. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200209-1112oc

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.