The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Oxidative Stress in Severe Pulmonary Hypertension
Abstract
Severe pulmonary hypertension (PH) occurs in a primary or "unexplained" form and in a group of secondary forms associated with a number of diseases. Because the lung tissue from patients with severe PH demonstrates complex vascular lesions, which contain inflammatory cells, we wondered whether the lung tissue from patients with severe PH was "under oxidative stress." We used immunohistochemistry to localize nitrotyrosine and 8-hydroxy guanosine in the lung tissue sections from patients with primary and secondary PH. In some lung tissue extracts, the eicosanoid metabolites 5-oxo-eicosatetraenoic acid, leukotriene B4 5-hydroxyeicosatetraenoic acid (HETE), 12-HETE, and 15-HETE were measured using mass spectroscopy, and superoxide dismutase amount and activity were measured. Nitrotyrosine expression was ubiquitous in all PH lungs, and 5-oxo-eicosatetraenoic acid and HETE levels were elevated in the lungs of patients with severe PH but not in those lungs that were from the patients with severe PH treated chronically with prostacyclin. We conclude that indeed the lungs from patients with severe PH are under oxidative stress and that chronic prostacyclin infusion has an antiinflammatory effect on the lung tissue.
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Physiological functions of thioredoxin and thioredoxin reductase
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Oxidative Stress as a Regulator of Gene Expression in the Vasculature
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Pathological implications of nitric oxide, superoxide and peroxynitrite formation
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Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.
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Role of Oxidants in NF-κB Activation and TNF-α Gene Transcription Induced by Hypoxia and Endotoxin
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Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P. (2018) · Physiological Reviews · doi:10.1152/physrev.00001.2017 · Cited by 572
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Safety of sapropterin dihydrochloride (6r–bh4) in patients with pulmonary hypertension
Robbins, I. M., Hemnes, A. R., Simon Gibbs, J., Christman, B. W., Howard, L., Meehan, S., Cabrita, I., Gonzalez, R., Oyler, T., Zhao, L., et al. (2011) · Experimental Lung Research · doi:10.3109/01902148.2010.512972 · Cited by 47
Metadata
- Authors
- Bowers, R., Cool, C., Murphy, R. C., Tuder, R. M., Hopken, M. W., Flores, S. C., & Voelkel, N. F.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-03-15
- Volume
- 169
- Issue
- 6
- Pages
- 764-769
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2047774204
- Cited by
- 366
- References
- 36
- FWCI
- 13.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bowers, R., Cool, C., Murphy, R. C., Tuder, R. M., Hopken, M. W., Flores, S. C., & Voelkel, N. F. (2004). Oxidative Stress in Severe Pulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200301-147oc
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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