The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Prognostic Value of Desaturation during a 6-Minute Walk Test in Idiopathic Interstitial Pneumonia
Abstract
Exercise-induced hypoxia is an index of the severity of interstitial lung disease. We hypothesized that desaturation during a 6-minute walk test would predict mortality for patients with usual interstitial pneumonia (n = 83) and nonspecific interstitial pneumonia (n = 22). Consecutive patients with biopsy-proven disease performed a 6-minute walk test between January 1996 and December 2001. Desaturation was defined as a fall in oxygen saturation to 88% or less during the 6-minute walk test. Desaturation was common (44 of 83 usual interstitial pneumonia and 8 of 22 nonspecific interstitial pneumonia; chi square, p = 0.39). Patients with usual interstitial pneumonia or nonspecific interstitial pneumonia who desaturated had a significantly higher mortality than patients who did not desaturate (respective log-rank tests, p = 0.0018, p = 0.0089). In patients with usual interstitial pneumonia, the presence of desaturation was associated with an increased hazard of death (hazard ratio, 4.2; 95% confidence interval, 1.40, 12.56; p = 0.01) after adjusting for age, sex, smoking, baseline diffusion capacity for carbon monoxide, FVC, and resting saturation. We conclude that knowledge of desaturation during a 6-minute walk test adds prognostic information for patients with usual interstitial pneumonia and nonspecific interstitial pneumonia.
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Cites
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Cited by
Raghu, G., Collard, H. R., Egan, J. J., Martinez, F. J., Behr, J., Brown, K. K., Colby, T. V., Cordier, J.-F., Flaherty, K. R., Lasky, J. A., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2009-040gl · Cited by 7,186
Self-citationOrens, J. B., Estenne, M., Arcasoy, S., Conte, J. V., Corris, P., Egan, J. J., Egan, T., Keshavjee, S., Knoop, C., Kotloff, R., et al. (2006) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2006.03.011 · Cited by 1,073
High-Dose Acetylcysteine in Idiopathic Pulmonary Fibrosis
Demedts, M., Behr, J., Buhl, R., Costabel, U., Dekhuijzen, R., Jansen, H. M., MacNee, W., Thomeer, M., Wallaert, B., Laurent, F., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042976 · Cited by 964
The six‐minute walk test: a useful metric for the cardiopulmonary patient
Rasekaba, T., Lee, A. L., Naughton, M. T., Williams, T. J., & Holland, A. E. (2009) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2008.01880.x · Cited by 417
Agarwala, P., & Salzman, S. H. (2020) · Chest · doi:10.1016/j.chest.2019.10.014 · Cited by 394
Metadata
- Authors
- Lama, V. N., Flaherty, K. R., Toews, G. B., Colby, T. V., Travis, W. D., Long, Q., Murray, S., Kazerooni, E. A., Gross, B. H., Lynch, J. P., & Martinez, F. J.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-11-01
- Volume
- 168
- Issue
- 9
- Pages
- 1084-1090
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2117681009
- Cited by
- 555
- References
- 52
- FWCI
- 19.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Lama, V. N., Flaherty, K. R., Toews, G. B., Colby, T. V., Travis, W. D., Long, Q., Murray, S., Kazerooni, E. A., Gross, B. H., Lynch, J. P., & Martinez, F. J. (2003). Prognostic Value of Desaturation during a 6-Minute Walk Test in Idiopathic Interstitial Pneumonia. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200302-219oc
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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