The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cough-generated Aerosols of Mycobacterium tuberculosis: A New Method to Study Infectiousness
Abstract
The concentration and size distribution of infectious aerosols produced by patients with pulmonary tuberculosis (TB) has never been directly measured. We aimed to assess the feasibility of a method that we developed to collect and quantify culturable cough-generated aerosols of Mycobacterium tuberculosis. Subjects were recruited from a referral hospital and most had multidrug-resistant TB. They coughed into a chamber containing microbial air samplers while cough frequency was measured during two 5-minute sessions. Cough-generated aerosol cultures were positive in 4 of 16 subjects (25%) with smear-positive pulmonary TB. There was a rapid decrease in the cough-generated aerosol cultures within the first 3 weeks of effective treatment. Culture-positive cough aerosols were associated with lack of treatment during the previous week (p = 0.007), and there was a trend in the association with cough frequency (p = 0.08). The size distributions of these aerosols were variable, but most particle sizes were in the respirable range. Quantification of viable cough-generated aerosols is feasible and offers a new approach to study infectiousness and transmission of M. tuberculosis and other airborne pathogens.
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RILEY, R. L., MILLS, C. C., NYKA, W., WEINSTOCK, N., STOREY, P. B., SULTAN, L. U., RILEY, M. C., & WELLS, W. F. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117542 · Cited by 269
Cited by
HIV and Tuberculosis: a Deadly Human Syndemic
Kwan, C. K., & Ernst, J. D. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00042-10 · Cited by 720
The role of particle size in aerosolised pathogen transmission: a review
Gralton, J., Tovey, E., McLaws, M.-L., & Rawlinson, W. D. (2011) · Journal of Infection · doi:10.1016/j.jinf.2010.11.010 · Cited by 665
Particle Sizes of Infectious Aerosols: Implications for Infection Control
Fennelly, K. P. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30323-4 · Cited by 621
Self-citationVuorinen, V., Aarnio, M., Alava, M., Alopaeus, V., Atanasova, N., Auvinen, M., Balasubramanian, N., Bordbar, H., Erästö, P., Grande, R., et al. (2020) · Safety Science · doi:10.1016/j.ssci.2020.104866 · Cited by 472
Influenza Virus in Human Exhaled Breath: An Observational Study
Fabian, P., McDevitt, J. J., DeHaan, W. H., Fung, R. O. P., Cowling, B. J., Chan, K. H., Leung, G. M., & Milton, D. K. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002691 · Cited by 496
Metadata
- Authors
- Fennelly, K. P., Martyny, J. W., Fulton, K. E., Orme, I. M., Cave, D. M., & Heifets, L. B.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-03-01
- Volume
- 169
- Issue
- 5
- Pages
- 604-609
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1955121674
- Cited by
- 327
- References
- 1
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fennelly, K. P., Martyny, J. W., Fulton, K. E., Orme, I. M., Cave, D. M., & Heifets, L. B. (2004). Cough-generated Aerosols of Mycobacterium tuberculosis: A New Method to Study Infectiousness. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200308-1101oc
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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