The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Assist–Control Mechanical Ventilation Attenuates Ventilator-induced Diaphragmatic Dysfunction
Abstract
Controlled mechanical ventilation induced a profound diaphragm muscle dysfunction and atrophy. The effects of diaphragmatic contractions with assisted mechanical ventilation on diaphragmatic isometric, isotonic contractile properties, or the expression of muscle atrophy factor-box (MAF-box), the gene responsible for muscle atrophy, are unknown. We hypothesize that assisted mechanical ventilation will preserve diaphragmatic force and prevent overexpression of MAF-box. Studying sedated rabbits randomized equally into control animals, those with 3 days of assisted ventilation, and those with controlled ventilation, we assessed in vitro diaphragmatic isometric and isotonic contractile function. The concentrations of contractile proteins, myosin heavy chain isoform, and MAF-box mRNA were measured. Tetanic force decreased by 14% with assisted ventilation and 48% with controlled ventilation. Maximum shortening velocity tended to increase with controlled compared with assisted ventilation and control. Peak power output decreased 20% with assisted ventilation and 41% with controlled ventilation. Contractile proteins were unchanged with either modes of ventilation; myosin heavy chain 2X mRNA tended to increase and that of 2A to decrease with controlled ventilation. MAF-box gene was overexpressed with controlled ventilation. We conclude that preserving diaphragmatic contractions during mechanical ventilation attenuates the force loss induced by complete inactivity and maintains MAF-box gene expression in control.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Identification of ubiquitin ligases required for skeletal muscle atrophy.
Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521
Mechanisms of Muscle Wasting — The Role of the Ubiquitin–Proteasome Pathway
Mitch, W. E., & Goldberg, A. L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612193352507 · Cited by 1,166
Measurement of piezoelectric coefficients of ferroelectric thin films
Lefki, K., & Dormans, G. J. M. (1994) · Journal of Applied Physics · doi:10.1063/1.357693 · Cited by 593
Ventilator-induced Diaphragmatic Dysfunction
Vassilakopoulos, T., & Petrof, B. J. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200304-489cp · Cited by 520
Transthyretin (Prealbumin) in Health and Disease: Nutritional Implications
Ingenbleek, Y., & Young, V (1994) · Annual Review of Nutrition · doi:10.1146/annurev.nu.14.070194.002431 · Cited by 375
First and last experiments in muscle mechanics
Hill, A. V. (1970) · Cambridge University Press eBooks · Cited by 371
Shanely, R. A., Zergeroglu, M. A., Lennon, S. L., Sugiura, T., Yimlamai, T., Enns, D., Belcastro, A., & Powers, S. K. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200202-088oc · Cited by 348
Mechanical ventilation results in progressive contractile dysfunction in the diaphragm
Powers, S. K., Shanely, R. A., Coombes, J. S., Koesterer, T. J., McKenzie, M., Van Gammeren, D., Cicale, M., & Dodd, S. L. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00881.2001 · Cited by 319
Altered diaphragm contractile properties with controlled mechanical ventilation
Sassoon, C. S. H., Caiozzo, V. J., Mańka, A., & Sieck, G. C. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01213.2001 · Cited by 293
Self-citationEffects of mechanical ventilation on diaphragmatic contractile properties in rats.
Le Bourdelles, G., Viires, N., Boczkowski, J., Seta, N., Pavlovic, D., & Aubier, M. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.6.8004310 · Cited by 275
Cited by
Patient-ventilator asynchrony during assisted mechanical ventilation
Thille, A. W., Rodriguez, P., Cabello, B., Lellouche, F., & Brochard, L. (2006) · Intensive Care Medicine · doi:10.1007/s00134-006-0301-8 · Cited by 930
Evolution of Diaphragm Thickness during Mechanical Ventilation. Impact of Inspiratory Effort
Goligher, E. C., Fan, E., Herridge, M. S., Murray, A., Vorona, S., Brace, D., Rittayamai, N., Lanys, A., Tomlinson, G., Singh, J. M., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201503-0620oc · Cited by 608
Respiratory weakness is associated with limb weakness and delayed weaning in critical illness*
De Jonghe, B., Bastuji-Garin, S., Durand, M.-C., Malissin, I., Rodrigues, P., Cerf, C., Outin, H., & Sharshar, T. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000281450.01881.d8 · Cited by 554
Yoshida, T., Fujino, Y., Amato, M. B. P., & Kavanagh, B. P. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201604-0748cp · Cited by 346
Callahan, L. A., & Supinski, G. S. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181b6e439 · Cited by 298
Metadata
- Authors
- Sassoon, C. S. H., Zhu, E., & Caiozzo, V. J.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-09-15
- Volume
- 170
- Issue
- 6
- Pages
- 626-632
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2099951310
- Cited by
- 324
- References
- 28
- FWCI
- 8.59
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Assist–Control Mechanical Ventilation Attenuates Ventilator-induced Diaphragmatic Dysfunction. https://app.cochat.ai/papers/10.1164/rccm.200401-042oc
- The paper
- Sassoon, C. S. H., Zhu, E., & Caiozzo, V. J. (2004). Assist–Control Mechanical Ventilation Attenuates Ventilator-induced Diaphragmatic Dysfunction. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200401-042oc
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
