The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
F ifty Y ears of R esearch in ARDS. Spontaneous Breathing during Mechanical Ventilation. Risks, Mechanisms, and Management
Abstract
Spontaneous respiratory effort during mechanical ventilation has long been recognized to improve oxygenation, and because oxygenation is a key management target, such effort may seem beneficial. Also, disuse and loss of peripheral muscle and diaphragm function is increasingly recognized, and thus spontaneous breathing may confer additional advantage. Reflecting this, epidemiologic data suggest that the use of partial (vs. full) support modes of ventilation is increasing. Notwithstanding the central place of spontaneous breathing in mechanical ventilation, accumulating evidence indicates that it may cause-or worsen-acute lung injury, especially if acute respiratory distress syndrome is severe and spontaneous effort is vigorous. This Perspective reviews the evidence for this phenomenon, explores mechanisms of injury, and provides suggestions for clinical management and future research.
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Citations
Cites
Acute Respiratory Distress Syndrome: The Berlin Definition
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Self-citationNeuromuscular Blockers in Early Acute Respiratory Distress Syndrome
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Rapid Disuse Atrophy of Diaphragm Fibers in Mechanically Ventilated Humans
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Patient-ventilator asynchrony during assisted mechanical ventilation
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Tidal Hyperinflation during Low Tidal Volume Ventilation in Acute Respiratory Distress Syndrome
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Evolution of Mortality over Time in Patients Receiving Mechanical Ventilation
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Cited by
Tonelli, R., Fantini, R., Tabbì, L., Castaniere, I., Pisani, L., Pellegrino, M. R., Della Casa, G., D’Amico, R., Girardis, M., Nava, S., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201912-2512oc · Cited by 274
Tarazan, N., Alshehri, M., Sharif, S., Al Duhailib, Z., Møller, M. H., Belley-Cote, E., Alshahrani, M., Centofanti, J., McIntyre, L., Baw, B., et al. (2020) · Intensive Care Medicine Experimental · doi:10.1186/s40635-020-00348-6 · Cited by 52
Metadata
- Authors
- Yoshida, T., Fujino, Y., Amato, M. B. P., & Kavanagh, B. P.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-04-15
- Volume
- 195
- Issue
- 8
- Pages
- 985-992
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2541706955
- Cited by
- 346
- References
- 41
- FWCI
- 20.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: F ifty Y ears of R esearch in ARDS. Spontaneous Breathing during Mechanical Ventilation. Risks, Mechanisms, and Management. https://app.cochat.ai/papers/10.1164/rccm.201604-0748cp
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- Yoshida, T., Fujino, Y., Amato, M. B. P., & Kavanagh, B. P. (2017). F ifty Y ears of R esearch in ARDS. Spontaneous Breathing during Mechanical Ventilation. Risks, Mechanisms, and Management. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201604-0748cp
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