The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Increased Expression of Transient Receptor Potential Vanilloid-1 in Airway Nerves of Chronic Cough
Abstract
Transient receptor potential vanniloid-1 (TRPV-1) mediates the cough response induced by the pepper extract capsaicin and is expressed in sensory nerves that innervate the airway wall. We determined the expression of TRPV-1 in the airways of patients with chronic persistent cough of diverse causes and with an enhanced capsaicin cough response. We obtained airway mucosal biopsies by fiberoptic bronchoscopy in 29 patients with chronic cough and 16 healthy volunteers without a cough. Immunostaining for nerve profiles with anti-protein gene product (PGP)-9.5 antibody showed no increase in nerve profiles in the airway epithelium of patients with chronic cough; however, with an anti-TRPV-1 antibody, there was a fivefold increase of TRPV-1 staining nerve profiles (p < 0.001). There was a significant correlation between capsaicin tussive response and the number of TRPV-1-positive nerves within the patients with cough. Our findings indicate that TRPV-1 receptors may contribute to an enhanced cough reflex and the cough response in chronic persistent cough of diverse causes.
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Citations
Cites
The anandamide transport inhibitor AM404 activates vanilloid receptors
Zygmunt, P. M., Chuang, H.-H., Movahed, P., Julius, D., & Högestätt, E. D. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00207-7 · Cited by 270
Cited by
Prevalence, pathogenesis, and causes of chronic cough
Chung, K. F., & Pavord, I. D. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60595-4 · Cited by 665
Self-citationRecommendations for the management of cough in adults
Morice, A. H. (2006) · Thorax · doi:10.1136/thx.2006.065144 · Cited by 572
Transient receptor potential (TRP) channels: a clinical perspective
Kaneko, Y., & Szallasi, A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12414 · Cited by 370
Vagal afferent nerves regulating the cough reflex
Canning, B. J., Mori, N., & Mazzone, S. B. (2006) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2006.03.001 · Cited by 260
Gavva, N. R., Bannon, A. W., Hovland, D. N., Lehto, S. G., Klionsky, L., Surapaneni, S., Immke, D. C., Henley, C., Arik, L., Bak, A., et al. (2007) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.125674 · Cited by 180
Metadata
- Authors
- Groneberg, D. A., Niimi, A., Dinh, Q. T., Cosio, B., Hew, M., Fischer, A., & Chung, K. F.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-12-15
- Volume
- 170
- Issue
- 12
- Pages
- 1276-1280
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2037429300
- Cited by
- 396
- References
- 1
- FWCI
- 14.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Groneberg, D. A., Niimi, A., Dinh, Q. T., Cosio, B., Hew, M., Fischer, A., & Chung, K. F. (2004). Increased Expression of Transient Receptor Potential Vanilloid-1 in Airway Nerves of Chronic Cough. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200402-174oc
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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