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Cited by 449Air Quality and Health ImpactsClimate Change and Health ImpactsIndoor Air Quality and Microbial Exposure

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Acute Effects of Ozone on Mortality from the “Air Pollution and Health

Gryparis, Alexandros, Forsberg, Bertil, Katsouyanni, Klea, Analitis, Antonis, Touloumi, Giota, Schwartz, Joel, Samoli, Evangelia, Medina, Sylvia, Anderson, H. Ross, Niciu, Emilia Maria, Wichmann, H.-Erich, Kriz, Bohumir, Kosnik, Mitja, Skorkovsky, Jiri, Vonk, Judith M., Dörtbudak, Zeynep·2004·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.200403-333oc
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Abstract

In the Air Pollution and Health: A European Approach (APHEA2) project, the effects of ambient ozone concentrations on mortality were investigated. Data were collected on daily ozone concentrations, the daily number of deaths, confounders, and potential effect modifiers from 23 cities/areas for at least 3 years since 1990. Effect estimates were obtained for each city with city-specific models and were combined using second-stage regression models. No significant effects were observed during the cold half of the year. For the warm season, an increase in the 1-hour ozone concentration by 10 μg/m3 was associated with a 0.33% (95% confidence interval [CI], 0.17–0.52) increase in the total daily number of deaths, 0.45% (95% CI, 0.22–0.69) in the number of cardiovascular deaths, and 1.13% (95% CI, 0.62–1.48) in the number of respiratory deaths. The corresponding figures for the 8-hour ozone were similar. The associations with total mortality were independent of SO2 and particulate matter with aerodynamic diameter less than 10 μm (PM10) but were somewhat confounded by NO2 and CO. Individual city estimates were heterogeneous for total (a higher standardized mortality rate was associated with larger effects) and cardiovascular mortality (larger effects were observed in southern cities). The dose–response curve of ozone effects on total mortality during the summer did not deviate significantly from linearity.

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Research works printed but not linked: 42

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Metadata

Authors
Gryparis, A., Forsberg, B., Katsouyanni, K., Analitis, A., Touloumi, G., Schwartz, J., Samoli, E., Medina, S., Anderson, H. R., Niciu, E. M., Wichmann, H.-E., Kriz, B., Kosnik, M., Skorkovsky, J., Vonk, J. M., & Dörtbudak, Z.
Affiliations
  • University of London (GB)
  • Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece; Department of Biostatistics, Department of Public Health and Clinical Medicine, and Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts; Umeå University, Umeå, Sweden; Institut de Veille Sanitaire, Paris, France; St. George's Hospital Medical School, University of London, London, United Kingdom; Department of Environmental Health, Institute of Public Health, Bucharest, Romania; GSF, National Research Center for Environment and Health, Munich, Germany; Charles University, Prague; Institute of Hygiene, Teplice, Czech Republic; Institute of Public Health, Ljubljana, Slovenia; Department of Epidemiology and Statistics, University of Groningen, Groningen, The Netherlands; and Koç University, School of Health Sciences, Istanbul, Turkey
ORCID
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2004-11
Volume
170
Issue
10
Pages
1080-1087
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.200403-333oc
OpenAlex
W2127465067
Cited by
449
References
47
Citations by year
2026: 8 · 2025: 13 · 2024: 12 · 2023: 26 · 2022: 22 · 2021: 20 · 2020: 27 · 2019: 22 · 2018: 28 · 2017: 25 · 2016: 37 · 2015: 22 · 2014: 18 · 2013: 23 · 2012: 19
FWCI
9.64
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • American Journal of Respiratory and Critical Care Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Climate Change and Health Impacts
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Keywords
ozone, air pollution, mortality, cardiovascular mortality, respiratory mortality, dose-response relationship, sulfur dioxide, particulate matter, seasonal variation, urban air quality
MeSH terms
Air Pollutants, Cardiovascular Diseases, Cause of Death, Environmental Monitoring, Europe, Female, Humans, Male, Ozone, Registries, Regression Analysis, Respiratory Tract Diseases, Retrospective Studies, Urban Population, Incidence, Confidence Intervals, Odds Ratio, Risk Assessment, Epidemiological Monitoring

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