The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Pediatric Acute Lung Injury: Prospective Evaluation of Risk Factors Associated with Mortality
Abstract
RATIONALE: The 1994 American European Consensus Committee definitions of acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) have not been applied systematically in the pediatric population. OBJECTIVES: The purpose of this study was to evaluate prospectively the epidemiology and clinical risk factors associated with death and prolonged mechanical ventilation in all pediatric patients admitted to two large, pediatric intensive care units with ALI/ARDS using Consensus criteria. METHODS: All pediatric patients meeting Consensus Committee definitions for ALI were prospectively identified and included in a relational database. MEASUREMENTS AND MAIN RESULTS: There were 328 admissions for ALI/ARDS with a mortality of 22%. Multivariate logistic regression analyses revealed (1) the initial severity of oxygenation defect, as measured by the Pa(O2)/FI(O2) ratio; (2) the presence of nonpulmonary and non-central nervous system (CNS) organ dysfunction; and (3) the presence of CNS dysfunction were independently associated with mortality and prolonged mechanical ventilation. A substantial fraction of patients (28%) did not require mechanical ventilation at the onset of ALI; 46% of these patients eventually required intubation for worsening ALI. CONCLUSIONS: Mortality in pediatric ALI/ARDS is high and several risk factors have major prognostic value. In contrast to ALI/ARDS in adults, the initial severity of arterial hypoxemia in children correlates well with mortality. A significant fraction of patients with pediatric ALI/ARDS can be identified before endotracheal intubation is required. These patients provide a valuable group in whom new therapies can be tested.
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The Acute Respiratory Distress Syndrome
Ware, L. B., & Matthay, M. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421806 · Cited by 4,666
Self-citationAn Expanded Definition of the Adult Respiratory Distress Syndrome
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Self-citationPRISM III: An updated Pediatric Risk of Mortality score
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Pulmonary Dead-Space Fraction as a Risk Factor for Death in the Acute Respiratory Distress Syndrome
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Self-citationLung Epithelial Fluid Transport and the Resolution of Pulmonary Edema
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Self-citationNoninvasive Ventilation in Severe Hypoxemic Respiratory Failure: A Randomized Clinical Trial
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Self-citationAcute Lung Injury in the Medical ICU: Comorbid Conditions, Age, Etiology, and Hospital Outcome
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Cited by
The acute respiratory distress syndrome
Matthay, M. A., Ware, L. B., & Zimmerman, G. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60331 · Cited by 1,706
Self-citationThe Acute Respiratory Distress Syndrome: Pathogenesis and Treatment
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Self-citationAcute Lung Injury: Epidemiology, Pathogenesis, and Treatment
Johnson, E. R., & Matthay, M. A. (2010) · Journal of Aerosol Medicine and Pulmonary Drug Delivery · doi:10.1089/jamp.2009.0775 · Cited by 783
Self-citationDahlem, P., & Randolph, A. G. (2015) · Pediatric and Neonatal Mechanical Ventilation · doi:10.1007/978-3-642-01219-8_49 · Cited by 304
Clinical trials in acute respiratory distress syndrome: challenges and opportunities
Matthay, M. A., McAuley, D. F., & Ware, L. B. (2017) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(17)30188-1 · Cited by 284
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Metadata
- Authors
- Flori, H. R., Glidden, D. V., Rutherford, G. W., & Matthay, M. A.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-05-01
- Volume
- 171
- Issue
- 9
- Pages
- 995-1001
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1783656977
- Cited by
- 366
- References
- 33
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- closed
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