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The Prediction of Small Airway Dimensions Using Computed Tomography
Abstract
Chronic obstructive pulmonary disease is characterized by destruction of the lung parenchyma and/or small airway narrowing. To determine whether the dimensions of relatively large airways assessed using computed tomography (CT) reflect small airway dimensions measured histologically, we assessed these variables in nonobstructed or mild to moderately obstructed patients having lobar resection for a peripheral tumor. For both CT and histology, the square root of the airway wall area (Aaw) was plotted versus lumen perimeter to estimate wall thickness. The wall area percentage was calculated as wall area/lumen area + wall area x 100. Although CT overestimated Aaw, the slopes of the relationships between the square root of Aaw and internal perimeter (Pi) measured with both techniques were related (CT slope = 0.2059 histology slope + 0.1701, R2 = 0.32, p < 0.01). The mean wall area percentage measured by CT for airways with a Pi of greater than 0.75 cm predicted the mean dimensions of the small airways with an internal diameter of 1.27 mm (R2 = 0.57, p < 0.01). We conclude that CT measurements of airways with a Pi of 0.75 cm or more could be used to estimate the dimensions of the small conducting airways, which are the site of airway obstruction in chronic obstructive pulmonary disease.
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Cited by
Lynch, D. A., Austin, J. H. M., Hogg, J. C., Grenier, P. A., Kauczor, H.-U., Bankier, A. A., Barr, R. G., Colby, T. V., Galvin, J. R., Gevenois, P. A., et al. (2015) · Radiology · doi:10.1148/radiol.2015141579 · Cited by 658
Self-citationSchroeder, J. D., McKenzie, A. S., Zach, J. A., Wilson, C. G., Curran-Everett, D., Stinson, D. S., Newell, J. D., & Lynch, D. A. (2013) · American Journal of Roentgenology · doi:10.2214/ajr.12.10102 · Cited by 334
The clinical and genetic features of COPD-asthma overlap syndrome
Hardin, M., Cho, M., McDonald, M.-L., Beaty, T., Ramsdell, J., Bhatt, S., van Beek, E. J. R., Make, B. J., Crapo, J. D., Silverman, E. K., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00216013 · Cited by 294
Computed tomographic imaging of the airways: relationship to structure and function
de Jong, P. A., Müller, N. L., Paré, P. D., & Coxson, H. O. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00007105 · Cited by 171
Self-citationSex Differences in Emphysema and Airway Disease in Smokers
Camp, P. G., Coxson, H. O., Levy, R. D., Pillai, S. G., Anderson, W., Vestbo, J., Kennedy, S. M., Silverman, E. K., Lomas, D. A., & Paré, P. D. (2009) · Chest · doi:10.1378/chest.09-0676 · Cited by 99
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Metadata
- Authors
- Nakano, Y., Wong, J. C., de Jong, P. A., Buzatu, L., Nagao, T., Coxson, H. O., Elliott, W. M., Hogg, J. C., & Paré, P. D.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-01-15
- Volume
- 171
- Issue
- 2
- Pages
- 142-146
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2171506107
- Cited by
- 449
- References
- 0
- FWCI
- 9.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nakano, Y., Wong, J. C., de Jong, P. A., Buzatu, L., Nagao, T., Coxson, H. O., Elliott, W. M., Hogg, J. C., & Paré, P. D. (2005). The Prediction of Small Airway Dimensions Using Computed Tomography. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200407-874oc
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