The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Montelukast Reduces Asthma Exacerbations in 2- to 5-Year-Old Children with Intermittent Asthma
Abstract
The PREVIA study was designed to investigate the role of montelukast, a leukotriene receptor antagonist, in the prevention of viral-induced asthma exacerbations in children aged 2 to 5 years with a history of intermittent asthma symptoms. The study was a 12-month multicenter, double-blind, parallel-group study of patients with asthma exacerbations associated with respiratory infections and minimal symptoms between episodes. Patients were randomized to receive oral montelukast 4 or 5 mg (depending on age) (n = 278) or placebo (n = 271) once per day for 12 months. Caregivers recorded children's symptoms, beta-agonist use, and health care resource use in a diary card. Over 12 months of therapy, montelukast significantly reduced the rate of asthma exacerbations by 31.9% compared with placebo. The average rate of exacerbation episodes per patient was 1.60 episodes per year on montelukast compared with 2.34 episodes on placebo. Montelukast also delayed the median time to first exacerbation by approximately 2 months (p = 0.024), and the rate of inhaled corticosteroid courses (p = 0.027) compared with placebo. Montelukast effectively reduced asthma exacerbations in 2- to 5-year-old patients with intermittent asthma over 12 months of treatment and was generally well tolerated.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Community study of role of viral infections in exacerbations of asthma in 9–11 year old children
Johnston, S. L., Pattemore, P. K., Sanderson, G., Smith, S., Lampe, F., Josephs, L., Symington, P., Toole, S. O., Myint, S. H., Tyrrell, D. A. J., et al. (1995) · BMJ · doi:10.1136/bmj.310.6989.1225 · Cited by 1,991
Self-citationRespiratory viruses and exacerbations of asthma in adults
Nicholson, K. G., Kent, J., & Ireland, D. C. (1993) · BMJ · doi:10.1136/bmj.307.6910.982 · Cited by 1,127
Cited by
Global strategy for asthma management and prevention: GINA executive summary
Bateman, E. D., Hurd, S. S., Barnes, P. J., Bousquet, J., Drazen, J. M., FitzGerald, M., Gibson, P., Ohta, K., O'Byrne, P., Pedersen, S. E., et al. (2008) · European Respiratory Journal · doi:10.1183/09031936.00138707 · Cited by 3,203
Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report
Bacharier, L. B., Boner, A., Carlsen, K. ‐., Eigenmann, P. A., Frischer, T., Götz, M., Helms, P. J., Hunt, J., Liu, A., Papadopoulos, N., et al. (2008) · Allergy · doi:10.1111/j.1398-9995.2007.01586.x · Cited by 640
Preemptive Use of High-Dose Fluticasone for Virus-Induced Wheezing in Young Children
Ducharme, F. M., Lemire, C., Noya, F. J. D., Davis, G. M., Alos, N., Leblond, H., Savdie, C., Collet, J.-P., Khomenko, L., Rivard, G., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808907 · Cited by 306
Bacharier, L. B., Phillips, B. R., Zeiger, R. S., Szefler, S. J., Martinez, F. D., Lemanske, R. F., Sorkness, C. A., Bloomberg, G. R., Morgan, W. J., Paul, I. M., et al. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.09.029 · Cited by 270
Metadata
- Authors
- Bisgaard, H., Zielen, S., Garcia-Garcia, M. L., Johnston, S. L., Gilles, L., Menten, J., Tozzi, C. A., & Polos, P.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-02-15
- Volume
- 171
- Issue
- 4
- Pages
- 315-322
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2150557343
- Cited by
- 360
- References
- 2
- FWCI
- 15.20
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Montelukast Reduces Asthma Exacerbations in 2- to 5-Year-Old Children with Intermittent Asthma. https://app.cochat.ai/papers/10.1164/rccm.200407-894oc
- The paper
- Bisgaard, H., Zielen, S., Garcia-Garcia, M. L., Johnston, S. L., Gilles, L., Menten, J., Tozzi, C. A., & Polos, P. (2005). Montelukast Reduces Asthma Exacerbations in 2- to 5-Year-Old Children with Intermittent Asthma. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200407-894oc
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
