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Cited by 306

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Preemptive Use of High-Dose Fluticasone for Virus-Induced Wheezing in Young Children

Open access
Ducharme, Francine M., Lemire, Chantal, Noya, Francisco J.D., Davis, G. Michael, Alos, Nathalie, Leblond, Hélène, Savdie, Cheryl, Collet, Jean-Paul, Khomenko, Lyudmyla, Rivard, Georges, Platt, Robert W.·2009·New England Journal of Medicine
DOI 10.1056/nejmoa0808907
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Abstract

BACKGROUND: Although virus-induced wheezing is common in preschool-age children, optimal management remains elusive. We examined the efficacy and safety of preemptive treatment with high-dose fluticasone in reducing the severity of recurrent virus-induced wheezing in children. METHODS: We randomly assigned 129 children who were 1 to 6 years of age to receive 750 microg of fluticasone propionate (ex-valve [manufacturer-measured] dose) or placebo twice daily, beginning at the onset of an upper respiratory tract infection and continuing for a maximum of 10 days, over a period of 6 to 12 months. The primary outcome was rescue oral corticosteroid use. Secondary outcomes included symptoms, use of beta(2)-agonists, acute care visits, hospitalizations, discontinuation of the study drug, change in growth and bone mineral density, basal cortisol level, and adverse events. RESULTS: Over a median period of 40 weeks, 8% of upper respiratory tract infections in the fluticasone group led to treatment with rescue systemic corticosteroids, as compared with 18% in the placebo group (odds ratio, 0.49; 95% confidence interval [CI], 0.30 to 0.83). Children who were treated with fluticasone, as compared with those who were given placebo, had smaller mean (+/-SD) gains from baseline in height (6.23+/-2.62 cm [unadjusted value]; z score, -0.19 +/-0.42 vs. 6.56+/-2.90 cm [unadjusted value]; z score, 0.00+/-0.48; difference between groups in z score from baseline to end point, -0.24 [95% CI, -0.40 to -0.08]) and in weight (1.53+/-1.17 kg [unadjusted value]; z score, -0.15+/-0.48 vs. 2.17+/-1.79 kg [unadjusted value]; z score, 0.11+/-0.43; difference between groups in z score from baseline to end point, -0.26 [95% CI, -0.41 to -0.09]). There were no significant differences between the groups in basal cortisol level, bone mineral density, or adverse events. CONCLUSIONS: In preschool-age children with moderate-to-severe virus-induced wheezing, preemptive treatment with high-dose fluticasone as compared with placebo reduced the use of rescue oral corticosteroids. Treatment with fluticasone was associated with a smaller gain in height and weight. Given the potential for overuse, this preventive approach should not be adopted in clinical practice until long-term adverse effects are clarified. (ClinicalTrials.gov number, NCT00238927.)

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Metadata

Authors
Ducharme, F. M., Lemire, C., Noya, F. J. D., Davis, G. M., Alos, N., Leblond, H., Savdie, C., Collet, J.-P., Khomenko, L., Rivard, G., & Platt, R. W.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2009-01-22
Volume
360
Issue
4
Pages
339-353
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa0808907
OpenAlex
W2038229245
Cited by
306
References
32
FWCI
23.23
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Preemptive Use of High-Dose Fluticasone for Virus-Induced Wheezing in Young Children. https://app.cochat.ai/papers/10.1056/nejmoa0808907
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Ducharme, F. M., Lemire, C., Noya, F. J. D., Davis, G. M., Alos, N., Leblond, H., Savdie, C., Collet, J.-P., Khomenko, L., Rivard, G., & Platt, R. W. (2009). Preemptive Use of High-Dose Fluticasone for Virus-Induced Wheezing in Young Children. New England Journal of Medicine. https://doi.org/10.1056/nejmoa0808907

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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