The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing
Open accessAbstract
Background Acute wheezing illnesses in preschoolers need better management strategies to reduce morbidity. Objectives To examine the effectiveness of episodic use of an inhaled corticosteroid and a leukotriene receptor antagonist in preschoolers with intermittent wheezing. Methods In a randomized, double-blind placebo-controlled twelve-month trial, 238 children aged 12-59 months with moderate-severe intermittent wheezing received 7-days of either budesonide inhalation suspension (1mg twice daily), montelukast (4mg daily), or placebos in addition to albuterol with each identified respiratory tract illness. Proportion of episode-free days (EFDs) during the 12-month trial was the primary outcome. Results The three treatment groups did not differ in proportions of EFDs, with adjusted mean (95% CI) EFDs of 76% (70%, 81%) for budesonide, 73% (66%, 79%) for montelukast, and 74% (65%, 81%) for conventional therapy (p=0.66). The three groups did not differ in oral corticosteroid use, health care utilization, quality of life, or linear growth. However, during respiratory tract illnesses, budesonide and montelukast therapy led to modest reductions in trouble breathing [(38% (p=0.003) and 37% (p=0.003)] and interference with activity scores [32% (p=0.01) and 40% (p=0.001)], most evident in those with positive asthma predictive indices. Conclusions In preschool children with moderate-to-severe intermittent wheezing, episodic use of either budesonide or montelukast early in respiratory tract illnesses, when added to albuterol, did not increase the proportion of EFDs or decrease oral corticosteroid use over a twelve-month period. However, indicators of severity of acute illnesses were reduced, particularly in children with positive asthma predictive indices. Capsule Summary The episodic use of budesonide or montelukast in preschool children with moderate-to-severe intermittent wheezing does not increase the proportion of episode free days, but decreases symptom severity during acute respiratory tract illnesses.
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Chronic Obstructive Pulmonary Disease Surveillance—United States, 1971–2000
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Long-Term Inhaled Corticosteroids in Preschool Children at High Risk for Asthma
Guilbert, T. W., Morgan, W. J., Zeiger, R. S., Mauger, D. T., Boehmer, S. J., Szefler, S. J., Bacharier, L. B., Lemanske, R. F., Strunk, R. C., Allen, D. B., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa051378 · Cited by 1,054
Self-citationTrends in Childhood Asthma: Prevalence, Health Care Utilization, and Mortality
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Intermittent Inhaled Corticosteroids in Infants with Episodic Wheezing
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Montelukast Reduces Asthma Exacerbations in 2- to 5-Year-Old Children with Intermittent Asthma
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Lötvall, J., Akdis, C. A., Bacharier, L. B., Bjermer, L., Casale, T. B., Custovic, A., Lemanske, R. F., Wardlaw, A. J., Wenzel, S. E., & Greenberger, P. A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.037 · Cited by 1,160
Self-citationCloutier, M. M., Baptist, A. P., Blake, K. V., Brooks, E. G., Bryant-Stephens, T., DiMango, E., Dixon, A. E., Elward, K. S., Hartert, T., Krishnan, J. A., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.10.003 · Cited by 854
Self-citationA summary of the new GINA strategy: a roadmap to asthma control
Reddel, H. K., Bateman, E. D., Becker, A., Boulet, L.-P., Cruz, A. A., Drazen, J. M., Haahtela, T., Hurd, S. S., Inoue, H., de Jongste, J. C., et al. (2015) · European Respiratory Journal · doi:10.1183/13993003.00853-2015 · Cited by 788
Self-citationGlobal strategy for the diagnosis and management of asthma in children 5 years and younger
Pedersen, S. E., Hurd, S. S., Lemanske, R. F., Becker, A., Zar, H. J., Sly, P. D., Soto‐Quiroz, M., Wong, G., & Bateman, E. D. (2011) · Pediatric Pulmonology · doi:10.1002/ppul.21321 · Cited by 326
Self-citationBacharier, L. B., Guilbert, T. W., Mauger, D. T., Boehmer, S., Beigelman, A., Fitzpatrick, A. M., Jackson, D. J., Baxi, S. N., Benson, M., Burnham, C.-A. D., et al. (2015) · JAMA · doi:10.1001/jama.2015.13896 · Cited by 287
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Metadata
- Authors
- Bacharier, L. B., Phillips, B. R., Zeiger, R. S., Szefler, S. J., Martinez, F. D., Lemanske, R. F., Sorkness, C. A., Bloomberg, G. R., Morgan, W. J., Paul, I. M., Guilbert, T., Krawiec, M., Covar, R., Larsen, G., Mellon, M., Moss, M. H., Chinchilli, V. M., Taussig, L. M., & Strunk, R. C.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 122
- Issue
- 6
- Pages
- 1127-1135.e8
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2030827695
- Cited by
- 270
- References
- 26
- FWCI
- 16.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bacharier, L. B., Phillips, B. R., Zeiger, R. S., Szefler, S. J., Martinez, F. D., Lemanske, R. F., Sorkness, C. A., Bloomberg, G. R., Morgan, W. J., Paul, I. M., Guilbert, T., Krawiec, M., Covar, R., Larsen, G., Mellon, M., Moss, M. H., Chinchilli, V. M., Taussig, L. M., & Strunk, R. C. (2008). Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2008.09.029
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