The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
One Hundred Years of Lung Cancer
Abstract
A hundred years ago, lung cancer was a reportable disease, and it is now the commonest cause of death from cancer in both men and women in the developed world, and before long, will reach that level in the developing world as well. The disease has no particular symptoms or signs for its detection at an early stage. Most patients therefore present with advanced stage IIIB or IV disease. Screening tests began in the 1950s with annual chest x-ray films and sputum cytology but they resulted in no improvement in overall mortality compared with control subjects. The same question is now being asked of spiral low-dose computed tomographic scanning. There have been big refinements in the staging classification of lung cancer and advances in stage identification using minimally invasive technology. Postsurgical mortality has declined from the early days of the 1950s but 5-year cure rates have only barely improved. The addition of chemotherapy to radical radiotherapy, together with novel radiotherapy techniques, is gradually improving the outcome for locally advanced, inoperable non-small cell lung cancer. Chemotherapy offers modest survival improvement for patients with non-small cell lung cancer, the modern agents being better tolerated resulting in an improved quality of life. The management of small cell lung cancer, which appeared so promising at the beginning of the 1970s, has hit a plateau with very little advance in outcome over the last 15 years. The most important and cost-effective management for lung cancer is smoking cessation, but for those with the disease, novel agents and treatment approaches are urgently needed.
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Lynch, T. J., Bell, D. W., Sordella, R., Gurubhagavatula, S., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Haserlat, S. M., Supko, J. G., Haluska, F. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040938 · Cited by 11,486
Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer
Ginsberg, R. J., & Rubinstein, L. V. (1995) · The Annals of Thoracic Surgery · doi:10.1016/0003-4975(95)00537-u · Cited by 3,006
Fukuoka, M., Yano, S., Giaccone, G., Tamura, T., Nakagawa, K., Douillard, J.-Y., Nishiwaki, Y., Vansteenkiste, J., Kudoh, S., Rischin, D., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.10.038 · Cited by 2,874
Non-small Cell Lung Cancer Collaborative Group (1995) · BMJ · doi:10.1136/bmj.311.7010.899 · Cited by 2,850
Kris, M. G., Natale, R. B., Herbst, R. S., Lynch, Jr., Prager, D., Belani, C. P., Schiller, J. H., Kelly, K., Spiridonidis, H., Sandler, A., et al. (2003) · JAMA · doi:10.1001/jama.290.16.2149 · Cited by 2,517
Early Lung Cancer Action Project: overall design and findings from baseline screening
Henschke, C. I., McCauley, D. I., Yankelevitz, D. F., Naidich, D. P., McGuinness, G., Miettinen, O. S., Libby, D. M., Pasmantier, M. W., Koizumi, J., Altorki, N. K., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(99)06093-6 · Cited by 2,508
(2004) · New England Journal of Medicine · doi:10.1056/nejmoa031644 · Cited by 2,335
Smoking and Carcinoma of the Lung
Doll, R., & Hill, A. B. (1950) · BMJ · doi:10.1136/bmj.2.4682.739 · Cited by 1,999
A New International Staging System for Lung Cancer
Mountain, C. F. (1986) · Chest · doi:10.1378/chest.89.4_supplement.225s · Cited by 1,659
Estimates of the worldwide mortality from 25 cancers in 1990
Pisani, P., Parkin, D. M., Bray, F., & Ferlay, J. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990924)83:1<18::aid-ijc5>3.0.co;2-m · Cited by 1,549
Cited by
Targeted Therapy and Checkpoint Immunotherapy in Lung Cancer
Ruiz-Cordero, R., & Devine, W. P. (2020) · Surgical Pathology Clinics · doi:10.1016/j.path.2019.11.002 · Cited by 448
Infante, M., Cavuto, S., Lutman, F. R., Brambilla, G., Chiesa, G., Ceresoli, G., Passera, E., Angeli, E., Chiarenza, M., Aranzulla, G., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200901-0076oc · Cited by 379
A Gene Expression Signature Predicts Survival of Patients with Stage I Non-Small Cell Lung Cancer
Lu, Y., Lemon, W., Liu, P.-Y., Yi, Y., Morrison, C., Yang, P., Sun, Z., Szoke, J., Gerald, W. L., Watson, M., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030467 · Cited by 323
A systematic review of the impact of stigma and nihilism on lung cancer outcomes
Chambers, S. K., Dunn, J., Occhipinti, S., Hughes, S., Baade, P., Sinclair, S., Aitken, J., Youl, P., & O’Connell, D. L. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-184 · Cited by 258
Advances in molecular pathology and therapy of non-small cell lung cancer
Huang, Q., Li, Y., Huang, Y., Wu, J., Bao, W., Xue, C., Li, X., Dong, S., Dong, Z., & Hu, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02243-6 · Cited by 197
Metadata
- Authors
- Spiro, S. G., & Silvestri, G. A.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-09-01
- Volume
- 172
- Issue
- 5
- Pages
- 523-529
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2053736534
- Cited by
- 379
- References
- 44
- FWCI
- 12.58
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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