The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
The β-Agonist Lung Injury Trial (BALTI): A Randomized Placebo-controlled Clinical Trial
Abstract
RATIONALE: Experimental data suggest that manipulation of alveolar fluid clearance with beta-agonists can accelerate the resolution of alveolar edema and improve survival. OBJECTIVE: To determine if a sustained infusion of intravenous salbutamol (albuterol) would accelerate the resolution of alveolar edema in adult patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). METHODS: This was a single-center, double-blind, randomized controlled trial. Patients with ALI/ARDS were randomized to treatment with intravenous salbutamol (15 microg kg(-1) h(-1)) or placebo for 7 d. The primary endpoint was extravascular lung water measured by thermodilution (PiCCO) at Day 7. MEASUREMENTS AND MAIN RESULTS: Sixty-six patients were screened; of these, 40 met the inclusion criteria and were enrolled during 2001-2003. Patients in the salbutamol group had significantly lower lung water at Day 7 than the placebo group (9.2 +/- 6 vs. 13.2 +/- 3 ml kg(-1); 95% confidence interval difference, 0.2-8.3 ml kg(-1); p = 0.038). Plateau airway pressure was lower at Day 7 in the salbutamol group (23.9 +/- 3.8 cm H2O) versus placebo (29.5 +/- 7.2 cm H2O; p = 0.049). There was a trend toward lower Murray lung injury score at Day 7 in the salbutamol group (1.7 +/- 0.9) versus placebo (2.0 +/- 0.6; p = 0.2). Patients in the salbutamol group had a higher incidence of supraventricular arrhythmias (26 vs. 10%; p = 0.2). CONCLUSION: Although further research is required to confirm the efficacy and safety of intravenous salbutamol in ALI/ARDS, this trial provides the first proof of principle that, in humans with ALI/ARDS, sustained treatment with intravenous beta-agonists reduces extravascular lung water.
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Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
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Surviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016.
Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4683-6 · Cited by 6,621
Surviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016.
Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., et al. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002255 · Cited by 3,652
Acute Lung Injury: Epidemiology, Pathogenesis, and Treatment
Johnson, E. R., & Matthay, M. A. (2010) · Journal of Aerosol Medicine and Pulmonary Drug Delivery · doi:10.1089/jamp.2009.0775 · Cited by 783
Pathophysiology of Acute Lung Injury and the Acute Respiratory Distress Syndrome
Ware, L. (2006) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-2006-948288 · Cited by 493
Metadata
- Authors
- Perkins, G. D., McAuley, D. F., Thickett, D. R., & Gao, F.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-02-01
- Volume
- 173
- Issue
- 3
- Pages
- 281-287
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1903803846
- Cited by
- 446
- References
- 34
- FWCI
- 23.92
- Type
- journal article
- Language
- en
- Open access
- closed
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