Cited by 160Respiratory viral infections researchAsthma and respiratory diseasesRespiratory Support and Mechanisms

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Antioxidant treatment ameliorates respiratory syncytial virus-induced disease and lung inflammation

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Castro, Shawn Monique, Guerrero-Plata, Antonieta, Suarez-Real, Giovanni, Adegboyega, Patrick A., Colasurdo, Giuseppe N., Khan, Amir M., Garofalo, Roberto P., Casola, Antonella·2006·American Journal of Respiratory and Critical Care Medicine

DOI 10.1164/rccm.200603-319ocPMC PMC2648297

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Abstract

RATIONALE: Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in children. No treatment has been shown to significantly improve the clinical outcome of patients with this infection. Recent evidence suggests that oxidative stress could play an important role in the pathogenesis of acute and chronic lung inflammatory diseases. We do not known whether RSV induces pulmonary oxidative stress and whether antioxidant treatment can modulate RSV-induced lung disease. OBJECTIVES: To investigate the effect of antioxidant administration on RSV-induced lung inflammation, clinical disease, and airway hyperreactivity (AHR). METHODS: BALB/c mice were infected with 10(7) plaque-forming units of RSV, in the presence or absence of orally administered butylated hydroxyanisole (BHA), an antioxidant. Malondialdehyde and 4-hydroxynonenal were measured in bronchoalveoar lavage (BAL) by colorimetric assay. Cytokines and chemokines were measured in BAL by Bio-Plex and leukotrienes were measured by enzyme-linked immunosorbent assay. AHR to methacholine challenge was measured by whole-body plethysmography. RESULTS: BHA treatment significantly attenuated RSV-induced lung oxidative stress, as indicated by the decrease of malondialdehyde and 4-hydroxynonenal content in BAL of RSV-infected mice. RSV-induced clinical illness and body weight loss were also reduced by BHA treatment, which inhibited neutrophil recruitment to the lung and significantly reduced pulmonary cytokine and chemokine production after RSV infection. Similarly, antioxidant treatment attenuated RSV-induced AHR. CONCLUSION: Modulation of oxidative stress represents a potential novel pharmacologic approach to ameliorate RSV-induced acute lung inflammation and potentially prevent long-term consequences associated with RSV infection, such as bronchial asthma.

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Authors: Castro, S. M., Guerrero-Plata, A., Suarez-Real, G., Adegboyega, P. A., Colasurdo, G. N., Khan, A. M., Garofalo, R. P., & Casola, A.
Affiliations: The University of Texas Medical Branch at Galveston (US)
ORCID: Guerrero-Plata, Antonieta
Khan, Amir M.
Garofalo, Roberto P.
Venue: American Journal of Respiratory and Critical Care Medicine
Publisher: Oxford University Press (OUP)
Published: 2006-12
Volume: 174
Issue: 12
Pages: 1361-1369
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/rccm.200603-319oc
PMC: PMC2648297
OpenAlex: W2111079603
Cited by: 160
References: 52
Citations by year: 2026: 3 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 11 · 2019: 6 · 2018: 10 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 8 · 2013: 10 · 2012: 7
FWCI: 6.35
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (06676, 062885, 053785)
National Institute of General Medical Sciences (F31GM072231)
National Institute of Allergy and Infectious Diseases (P01AI062885)
National Institute of Environmental Health Sciences (T32ES007254, T32-ES-07254, 06676)
Topics: Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Keywords: respiratory syncytial virus, antioxidant therapy, butylated hydroxyanisole, oxidative stress, lung inflammation, airway hyperresponsiveness, neutrophil recruitment, cytokines and chemokines, leukotrienes, malondialdehyde, 4-hydroxynonenal, asthma, pediatric respiratory infection
MeSH terms: Aldehydes, Animals, Antioxidants, Bronchoalveolar Lavage Fluid, Butylated Hydroxyanisole, Colorimetry, Enzyme-Linked Immunosorbent Assay, Female, Inflammation, Lung, Malondialdehyde, Mice, Inbred BALB C, Respiratory Hypersensitivity, Leukotrienes, Cytokines, Respiratory Syncytial Virus Infections, Oxidative Stress, Chemokines, Mice

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Antioxidant treatment ameliorates respiratory syncytial virus-induced disease and lung inflammation

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