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Antioxidant treatment ameliorates respiratory syncytial virus-induced disease and lung inflammation
Open accessAbstract
RATIONALE: Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in children. No treatment has been shown to significantly improve the clinical outcome of patients with this infection. Recent evidence suggests that oxidative stress could play an important role in the pathogenesis of acute and chronic lung inflammatory diseases. We do not known whether RSV induces pulmonary oxidative stress and whether antioxidant treatment can modulate RSV-induced lung disease. OBJECTIVES: To investigate the effect of antioxidant administration on RSV-induced lung inflammation, clinical disease, and airway hyperreactivity (AHR). METHODS: BALB/c mice were infected with 10(7) plaque-forming units of RSV, in the presence or absence of orally administered butylated hydroxyanisole (BHA), an antioxidant. Malondialdehyde and 4-hydroxynonenal were measured in bronchoalveoar lavage (BAL) by colorimetric assay. Cytokines and chemokines were measured in BAL by Bio-Plex and leukotrienes were measured by enzyme-linked immunosorbent assay. AHR to methacholine challenge was measured by whole-body plethysmography. RESULTS: BHA treatment significantly attenuated RSV-induced lung oxidative stress, as indicated by the decrease of malondialdehyde and 4-hydroxynonenal content in BAL of RSV-infected mice. RSV-induced clinical illness and body weight loss were also reduced by BHA treatment, which inhibited neutrophil recruitment to the lung and significantly reduced pulmonary cytokine and chemokine production after RSV infection. Similarly, antioxidant treatment attenuated RSV-induced AHR. CONCLUSION: Modulation of oxidative stress represents a potential novel pharmacologic approach to ameliorate RSV-induced acute lung inflammation and potentially prevent long-term consequences associated with RSV infection, such as bronchial asthma.
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“Vitamin C is an efficient water‐soluble antioxidant and the effects on the immune system can be explained by the protection against oxidative stress generated during infections (Akaike 2001; Castro 2006; Hemilä 1992).”
From Vitamin C for preventing and treating the common cold (2013) · cites this paper as Castro 2006
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Cites
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Vitamin C for preventing and treating the common cold
Hemilä, H., & Chalker, E. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000980.pub4 · Cited by 869
Activation of innate immune antiviral responses by Nod2
Sabbah, A., Chang, T. H., Harnack, R., Frohlich, V. C., Tominaga, K., Dube, P. H., Xiang, Y., & Bose, S. (2009) · Nature Immunology · doi:10.1038/ni.1782 · Cited by 754
Tetherin Inhibits HIV-1 Release by Directly Tethering Virions to Cells
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Metadata
- Authors
- Castro, S. M., Guerrero-Plata, A., Suarez-Real, G., Adegboyega, P. A., Colasurdo, G. N., Khan, A. M., Garofalo, R. P., & Casola, A.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-12
- Volume
- 174
- Issue
- 12
- Pages
- 1361-1369
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- PMC
- PMC2648297
- OpenAlex
- W2111079603
- Cited by
- 160
- References
- 52
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 11 · 2019: 6 · 2018: 10 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 8 · 2013: 10 · 2012: 7
- FWCI
- 6.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (06676, 062885, 053785)
- National Institute of General Medical Sciences (F31GM072231)
- National Institute of Allergy and Infectious Diseases (P01AI062885)
- National Institute of Environmental Health Sciences (T32ES007254, T32-ES-07254, 06676)
- Topics
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- respiratory syncytial virus, antioxidant therapy, butylated hydroxyanisole, oxidative stress, lung inflammation, airway hyperresponsiveness, neutrophil recruitment, cytokines and chemokines, leukotrienes, malondialdehyde, 4-hydroxynonenal, asthma, pediatric respiratory infection
- MeSH terms
- Aldehydes, Animals, Antioxidants, Bronchoalveolar Lavage Fluid, Butylated Hydroxyanisole, Colorimetry, Enzyme-Linked Immunosorbent Assay, Female, Inflammation, Lung, Malondialdehyde, Mice, Inbred BALB C, Respiratory Hypersensitivity, Leukotrienes, Cytokines, Respiratory Syncytial Virus Infections, Oxidative Stress, Chemokines, Mice
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