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Cited by 160Respiratory viral infections researchAsthma and respiratory diseasesRespiratory Support and Mechanisms

The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.

Antioxidant treatment ameliorates respiratory syncytial virus-induced disease and lung inflammation

Open access
Castro, Shawn Monique, Guerrero-Plata, Antonieta, Suarez-Real, Giovanni, Adegboyega, Patrick A., Colasurdo, Giuseppe N., Khan, Amir M., Garofalo, Roberto P., Casola, Antonella·2006·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.200603-319ocPMC PMC2648297
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Abstract

RATIONALE: Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in children. No treatment has been shown to significantly improve the clinical outcome of patients with this infection. Recent evidence suggests that oxidative stress could play an important role in the pathogenesis of acute and chronic lung inflammatory diseases. We do not known whether RSV induces pulmonary oxidative stress and whether antioxidant treatment can modulate RSV-induced lung disease. OBJECTIVES: To investigate the effect of antioxidant administration on RSV-induced lung inflammation, clinical disease, and airway hyperreactivity (AHR). METHODS: BALB/c mice were infected with 10(7) plaque-forming units of RSV, in the presence or absence of orally administered butylated hydroxyanisole (BHA), an antioxidant. Malondialdehyde and 4-hydroxynonenal were measured in bronchoalveoar lavage (BAL) by colorimetric assay. Cytokines and chemokines were measured in BAL by Bio-Plex and leukotrienes were measured by enzyme-linked immunosorbent assay. AHR to methacholine challenge was measured by whole-body plethysmography. RESULTS: BHA treatment significantly attenuated RSV-induced lung oxidative stress, as indicated by the decrease of malondialdehyde and 4-hydroxynonenal content in BAL of RSV-infected mice. RSV-induced clinical illness and body weight loss were also reduced by BHA treatment, which inhibited neutrophil recruitment to the lung and significantly reduced pulmonary cytokine and chemokine production after RSV infection. Similarly, antioxidant treatment attenuated RSV-induced AHR. CONCLUSION: Modulation of oxidative stress represents a potential novel pharmacologic approach to ameliorate RSV-induced acute lung inflammation and potentially prevent long-term consequences associated with RSV infection, such as bronchial asthma.

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Research works printed but not linked: 7

  1. 1999, J Pediatr, 135, 2
  2. 1986, Am J Dis Child, 140, 543
  3. 2000, Arch Biochem Biophys, 376, 1
  4. 1978, Acta Med Okayama, 32, 265
  5. 2002, Biomarkers, 7, 1
  6. 2004, Curr Opin Investig Drugs, 5, 862
  7. 2004, Am J Respir Crit Care Med, 169, 542

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Metadata

Authors
Castro, S. M., Guerrero-Plata, A., Suarez-Real, G., Adegboyega, P. A., Colasurdo, G. N., Khan, A. M., Garofalo, R. P., & Casola, A.
Affiliations
The University of Texas Medical Branch at Galveston (US)
ORCID
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2006-12
Volume
174
Issue
12
Pages
1361-1369
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.200603-319oc
PMC
PMC2648297
OpenAlex
W2111079603
Cited by
160
References
52
Citations by year
2026: 3 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 11 · 2019: 6 · 2018: 10 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 8 · 2013: 10 · 2012: 7
FWCI
6.35
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • American Journal of Respiratory and Critical Care Medicine (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (06676, 062885, 053785)
  • National Institute of General Medical Sciences (F31GM072231)
  • National Institute of Allergy and Infectious Diseases (P01AI062885)
  • National Institute of Environmental Health Sciences (T32ES007254, T32-ES-07254, 06676)
Topics
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Keywords
respiratory syncytial virus, antioxidant therapy, butylated hydroxyanisole, oxidative stress, lung inflammation, airway hyperresponsiveness, neutrophil recruitment, cytokines and chemokines, leukotrienes, malondialdehyde, 4-hydroxynonenal, asthma, pediatric respiratory infection
MeSH terms
Aldehydes, Animals, Antioxidants, Bronchoalveolar Lavage Fluid, Butylated Hydroxyanisole, Colorimetry, Enzyme-Linked Immunosorbent Assay, Female, Inflammation, Lung, Malondialdehyde, Mice, Inbred BALB C, Respiratory Hypersensitivity, Leukotrienes, Cytokines, Respiratory Syncytial Virus Infections, Oxidative Stress, Chemokines, Mice

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