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Cited by 306

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Incidence of Chronic Obstructive Pulmonary Disease in a Cohort of Young Adults According to the Presence of Chronic Cough and Phlegm

de Marco, Roberto, Accordini, Simone, Cerveri, Isa, Corsico, Angelo, Antó, Josep M., Künzli, Nino, Janson, Christer, Sunyer, Jordi, Jarvis, Deborah, Chinn, Susan, Vermeire, Paul, Svanes, Cecilie, Ackermann-Liebrich, Ursula, Gislason, Thorarinn, Heinrich, Joachim, Leynaert, Bénédicte, Neukirch, Françoise, Schouten, Jan P., Wjst, Matthias, Burney, Peter·2007·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.200603-381oc
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Abstract

RATIONALE: The few prospective studies aimed at assessing the incidence of chronic obstructive pulmonary disease (COPD) in relation to the presence of chronic cough/phlegm have produced contrasting results. OBJECTIVES: To assess the incidence of COPD in a cohort of young adults and to test whether chronic cough/phlegm and dyspnea are independent predictors of COPD. METHODS: An international cohort of 5,002 subjects without asthma (ages 20-44 yr) with normal lung function (FEV(1)/FVC ratio >/= 70%) from 12 countries was followed from 1991-2002 in the frame of the European Community Respiratory Health Survey II. Incident cases of COPD were those who had an FEV(1)/FVC ratio less than 70% at the end of the follow-up, but did not report having had a doctor diagnose asthma during the follow-up. MAIN RESULTS: The incidence rate of COPD was 2.8 cases/1,000/yr (95% confidence interval [CI], 2.3-3.3). Chronic cough/phlegm was an independent and statistically significant predictor of COPD (incidence rate ratio [IRR], 1.85; 95% CI, 1.17-2.93) after adjusting for smoking habits and other potential confounders, whereas dyspnea was not associated with the disease (IRR = 0.98; 95% CI, 0.64-1.50). Subjects who reported chronic cough/phlegm both at baseline and at the follow-up had a nearly threefold-increased risk of developing COPD with respect to asymptomatic subjects (IRR = 2.88; 95% CI, 1.44-5.79). CONCLUSIONS: The incidence of COPD is substantial even in young adults. The presence of chronic cough/phlegm identifies a subgroup of subjects with a high risk of developing COPD, independently of smoking habits.

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Metadata

Authors
de Marco, R., Accordini, S., Cerveri, I., Corsico, A., Antó, J. M., Künzli, N., Janson, C., Sunyer, J., Jarvis, D., Chinn, S., Vermeire, P., Svanes, C., Ackermann-Liebrich, U., Gislason, T., Heinrich, J., Leynaert, B., Neukirch, F., Schouten, J. P., Wjst, M., & Burney, P.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2007-01-01
Volume
175
Issue
1
Pages
32-39
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.200603-381oc
OpenAlex
W1964164058
Cited by
306
References
32
FWCI
12.61
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Incidence of Chronic Obstructive Pulmonary Disease in a Cohort of Young Adults According to the Presence of Chronic Cough and Phlegm. https://app.cochat.ai/papers/10.1164/rccm.200603-381oc
The paper
de Marco, R., Accordini, S., Cerveri, I., Corsico, A., Antó, J. M., Künzli, N., Janson, C., Sunyer, J., Jarvis, D., Chinn, S., Vermeire, P., Svanes, C., Ackermann-Liebrich, U., Gislason, T., Heinrich, J., Leynaert, B., Neukirch, F., Schouten, J. P., Wjst, M., & Burney, P. (2007). Incidence of Chronic Obstructive Pulmonary Disease in a Cohort of Young Adults According to the Presence of Chronic Cough and Phlegm. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200603-381oc

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.