Cited by 285Sepsis Diagnosis and TreatmentHealth disparities and outcomesNeonatal and Maternal Infections

The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.

Racial Variation in the Incidence, Care, and Outcomes of Severe Sepsis

Open access

Barnato, Amber E., Alexander, Sherri L., Linde-Zwirble, Walter T., Angus, Derek C.·2008·American Journal of Respiratory and Critical Care Medicine

DOI 10.1164/rccm.200703-480ocPMC PMC2720103

Open this paper in CoChat — free account

Abstract

Rationale: Higher rates of sepsis have been reported in minorities. Objectives: To explore racial differences in the incidence and associated case fatality of severe sepsis, accounting for clinical, social, health care service delivery, and geographic characteristics. Methods: Retrospective population-based cohort study using hospital discharge and U.S. Census data for all persons (n = 71,102,655) living in 68 hospital referral regions in six states. Measurements and Main Results: Age-, sex- and race-standardized severe sepsis incidence and inpatient case fatality rates, adjusted incidence rate ratios, and adjusted intensive care unit (ICU) admission and case fatality rate differences. Of 8,938,111 nonfederal hospitalizations, 282,292 had severe sepsis. Overall, blacks had the highest age- and sex-standardized population-based incidence (6.08/1,000 vs. 4.06/1,000 for Hispanics and 3.58/1,000 for whites) and ICU case fatality (32.1 vs. 30.4% for Hispanics and 29.3% for whites, P < 0.0001). Adjusting for differences in poverty in their region of residence, blacks still had a higher population-based incidence of severe sepsis (adjusted rate ratio, 1.44 [95% CI, 1.42–1.46]) than whites, but Hispanics had a lower incidence (adjusted rate ratio, 0.91 [0.90–0.92]). Among patients with severe sepsis admitted to the ICU, adjustments for clinical characteristics and the treating hospital fully explained blacks' higher ICU case fatality. Conclusions: Higher adjusted black incidence and the lower Hispanic incidence may reflect residual confounding, or it could signal biologic differences in susceptibility. Focused interventions to improve processes and outcomes of care at the hospitals that disproportionately treat blacks could narrow disparities in overall mortality from severe sepsis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1164/rccm.200703-480oc

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Untitled work
(2001) · RePEc: Research Papers in Economics · Cited by 27,577
Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases
DEYO, R. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90133-8 · Cited by 10,452
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503
Self-citation
Unequal treatment: confronting racial and ethnic disparities in health care
(2003) · Choice Reviews Online · doi:10.5860/choice.40-5843 · Cited by 7,043
The epidemiology of sepsis in the United States from 1979 through 2000
Martin, G. S., Mannino, D. M., Eaton, S., & Moss, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022139 · Cited by 5,841
Social determinants of health inequalities
Marmot, M. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71146-6 · Cited by 5,086
Measuring Social Class in US Public Health Research: Concepts, Methodologies, and Guidelines
Krieger, N., Williams, D. R., & Moss, N. (1997) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.18.1.341 · Cited by 2,767
Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure
Taylor, A. L., Ziesche, S., Yancy, C., Carson, P., D'Agostino, R., Ferdinand, K., Taylor, M., Adams, K., Sabolinski, M., Worcel, M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa042934 · Cited by 1,773
Epidemiology of Sepsis Syndrome in 8 Academic Medical Centers
Sands, K. (1997) · JAMA · doi:10.1001/jama.278.3.234 · Cited by 684
Use of Census-based Aggregate Variables to Proxy for Socioeconomic Group: Evidence from National Samples
Geronimus, A. T., & Bound, J. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009673 · Cited by 489

Show all 31 references

Research works printed but not linked: 5

1979, N Engl J Med, 348, 1546
1997, JAMA, 278, 234, 10.1001/jama.1997.03550030074038 · DOI
2007, JAMA, 297, 1455
2007, J Clin Epidemiol, 60, 155
2000, Health Care Financ Rev, 21, 107

Sorted by citations

Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Seymour, C. W., Liu, V. X., Iwashyna, T. J., Brunkhorst, F. M., Rea, T. D., Scherag, A., Rubenfeld, G., Kahn, J. M., Shankar-Hari, M., Singer, M., et al. (2016) · JAMA · doi:10.1001/jama.2016.0288 · Cited by 3,939
Self-citation
Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations.
Fleischmann, C., Scherag, A., Adhikari, N. K. J., Hartog, C. S., Tsaganos, T., Schlattmann, P., Angus, D. C., & Reinhart, K. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201504-0781oc · Cited by 3,548
Self-citation
Sepsis: pathophysiology and clinical management
Gotts, J. E., & Matthay, M. A. (2016) · BMJ · doi:10.1136/bmj.i1585 · Cited by 1,308
Epidemiology of severe sepsis
Mayr, F., Yende, S. P., & Angus, D. C. (2013) · Virulence · doi:10.4161/viru.27372 · Cited by 1,298
Self-citation
The Effect of Multidisciplinary Care Teams on Intensive Care Unit Mortality
Kim, M. M., Barnato, A. E., Angus, D. C., Fleisher, L., & Kahn, J. M. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.521 · Cited by 531
Self-citation
Population Burden of Long‐Term Survivorship After Severe Sepsis in Older Americans
Iwashyna, T. J., Cooke, C. R., Wunsch, H., & Kahn, J. M. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.03989.x · Cited by 516
The Era of Molecular and Other Non-Culture-Based Methods in Diagnosis of Sepsis
Mancini, N., Carletti, S., Ghidoli, N., Cichero, P., Burioni, R., & Clementi, M. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00043-09 · Cited by 403
Site of Death, Place of Care, and Health Care Transitions Among US Medicare Beneficiaries, 2000-2015
Teno, J. M., Gozalo, P. L., Trivedi, A. N., Bunker, J., Lima, J. C., Ogarek, J. A., & Mor, V. (2018) · JAMA · doi:10.1001/jama.2018.8981 · Cited by 395
Three-Year Outcomes for Medicare Beneficiaries Who Survive Intensive Care
Wunsch, H. (2010) · JAMA · doi:10.1001/jama.2010.216 · Cited by 390
Identifying Patients With Severe Sepsis Using Administrative Claims: Patient-Level Validation of the Angus Implementation of the International Consensus Conference Definition of Severe Sepsis
Iwashyna, T. J., Odden, A., Rohde, J., Bonham, C., Kuhn, L., Malani, P., Chen, L., & Flanders, S. (2014) · Medical Care · doi:10.1097/mlr.0b013e318268ac86 · Cited by 358
Infection Rate and Acute Organ Dysfunction Risk as Explanations for Racial Differences in Severe Sepsis
Mayr, F. (2010) · JAMA · doi:10.1001/jama.2010.851 · Cited by 324
Long-term Acute Care Hospital Utilization After Critical Illness
Kahn, J. M. (2010) · JAMA · doi:10.1001/jama.2010.761 · Cited by 299
The effect of comorbidity and age on hospital mortality and length of stay in patients with sepsis
Yang, Y., Yang, K. S., Hsann, Y. M., Lim, V., & Ong, B. C. (2009) · Journal of Critical Care · doi:10.1016/j.jcrc.2009.09.001 · Cited by 226
Association Between US Norepinephrine Shortage and Mortality Among Patients With Septic Shock
Vail, E. A., Gershengorn, H. B., Hua, M. S., Walkey, A. J., Rubenfeld, G. D., & Wunsch, H. (2017) · JAMA · doi:10.1001/jama.2017.2841 · Cited by 227
Human recombinant activated protein C for severe sepsis
Martí-Carvajal, A. J., Solà, I., Lathyris, D., & Cardona, A. F. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004388.pub5 · Cited by 213
The Host Response to Sepsis and Developmental Impact
Wynn, J. L., Cornell, T. T., Wong, H. R., Shanley, T. P., & Wheeler, D. S. (2010) · PEDIATRICS · doi:10.1542/peds.2009-3301 · Cited by 210
The burden of sepsis-associated mortality in the United States from 1999 to 2005: an analysis of multiple-cause-of-death data
Melamed, A., & Sorvillo, F. J. (2009) · Critical Care · doi:10.1186/cc7733 · Cited by 209
Comparison of Charlson comorbidity index with SAPS and APACHE scores for prediction of mortality following intensive care
Christensen, Johansen, M. B., Christiansen, C. F., Jensen, & Lemeshow (2011) · Clinical Epidemiology · doi:10.2147/clep.s20247 · Cited by 204
The Influence of Race/Ethnicity and Socioeconomic Status on End-of-Life Care in the ICU
Muni, S., Engelberg, R. A., Treece, P. D., Dotolo, D. G., & Curtis, J. R. (2011) · CHEST Journal · doi:10.1378/chest.10-3011 · Cited by 193
Racial Differences in Survival After In-Hospital Cardiac Arrest
Chan, P. S. (2009) · JAMA · doi:10.1001/jama.2009.1340 · Cited by 173
Healthcare Disparities in Critical Illness
Soto, G. J., Martin, G. S., & Gong, M. N. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182a84a43 · Cited by 166
Prediction of Critical Illness During Out-of-Hospital Emergency Care
Seymour, C. W. (2010) · JAMA · doi:10.1001/jama.2010.1140 · Cited by 163
Severe sepsis cohorts derived from claims-based strategies appear to be biased toward a more severely ill patient population.
Whittaker, S.-A., Mikkelsen, M. E., Gaieski, D. F., Koshy, S., Kean, C., & Fuchs, B. D. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827466f1 · Cited by 156
Disease Progression in Hemodynamically Stable Patients Presenting to the Emergency Department With Sepsis
Glickman, S. W., Cairns, C. B., Otero, R., Woods, C. W., Tsalik, E. L., Langley, R. J., van Velkinburgh, J. C., Park, L. P., Glickman, L. T., Fowler, V. G., et al. (2010) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2010.00664.x · Cited by 142
Epidemiologic trends of sepsis in western countries
Suárez-de-la-Rica, A., Gilsanz, F., & Maseda, E. (2016) · Annals of Translational Medicine · doi:10.21037/atm.2016.08.59 · Cited by 144
Gene expression profiling in sepsis: timing, tissue, and translational considerations
Maslove, D. M., & Wong, H. R. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.01.006 · Cited by 133
Spurious Inferences about Long-Term Outcomes: The Case of Severe Sepsis and Geriatric Conditions
Iwashyna, T. J., Netzer, G., Langa, K. M., & Cigolle, C. T. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201109-1660oc · Cited by 128
The Changing Epidemiology and Definitions of Sepsis
Kempker, J. A., & Martin, G. S. (2016) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2016.01.002 · Cited by 138
Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients
Martí-Carvajal, A. J., Solà, I., Gluud, C. N., Lathyris, D., & Anand, V. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004388.pub6 · Cited by 115
Racial Disparities in ICU Outcomes: A Systematic Review*
McGowan, S. K., Sarigiannis, K. A., Fox, S. C., Gottlieb, M. A., & Chen, E. (2022) · Critical Care Medicine · doi:10.1097/ccm.0000000000005269 · Cited by 108
Palliative care access for hospitalized patients with end‐stage liver disease across the United States
Rush, B. N. M., Walley, K. R., Celi, L. A., Rajoriya, N., & Brahmania, M. (2017) · Hepatology · doi:10.1002/hep.29297 · Cited by 105
Equitably Allocating Resources during Crises: Racial Differences in Mortality Prediction Models
Ashana, D. C., Anesi, G. L., Liu, V. X., Escobar, G. J., Chesley, C., Eneanya, N. D., Weissman, G. E., Miller, W. D., Harhay, M. O., & Halpern, S. D. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202012-4383oc · Cited by 98
Current Trends in Sepsis-Related Mortality in the United States*
Prest, J., Sathananthan, M., & Jeganathan, N. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005017 · Cited by 95
An Official American Thoracic Society Systematic Review: The Association between Health Insurance Status and Access, Care Delivery, and Outcomes for Patients Who Are Critically Ill
Fowler, R., Noyahr, L.-A., Thornton, J. D., Pinto, R. L., Kahn, J. M., Adhikari, N. K. J., Dodek, P., Khan, N. A., Kalb, T., Hill, A. D., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200902-0281st · Cited by 94
Do hospitals provide lower quality of care to black patients for pneumonia?*
Mayr, F., Yende, S. P., D’Angelo, G., Barnato, A. E., Kellum, J. A., Weissfeld, L. A., Yealy, D. M., Reade, M. C., Milbrandt, E. B., & Angus, D. C. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181c8fd58 · Cited by 94
Self-citation
Untitled work
Goodwin (2016) · doi:10.1016/j.chest.2016.07.004 · Cited by 86
Racial Differences in Mortality from Severe Acute Respiratory Failure in the United States, 2008–2012
Bime, C., Poongkunran, C., Borgstrom, M. C., Natt, B., DESAI, H. H., Parthasarathy, S., & Garcia, J. G. N. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201605-359oc · Cited by 86
Racial and Ethnic Disparities in Hospital Admissions from COVID-19: Determining the Impact of Neighborhood Deprivation and Primary Language
Ingraham, N. E., Purcell, L. N., Karam, B. S., Dudley, R. A., Usher, M. G., Warlick, C. A., Allen, M., Melton, G. B., Charles, A. G., & Tignanelli, C. J. (2021) · Journal of General Internal Medicine · doi:10.1007/s11606-021-06790-w · Cited by 84
The Relationship between Hospital Volume and Mortality in Mechanical Ventilation: An Instrumental Variable Analysis
Kahn, J. M., Have, T. R. T., & Iwashyna, T. J. (2009) · Health Services Research · doi:10.1111/j.1475-6773.2009.00959.x · Cited by 83
The effect of race and ethnicity on outcomes among patients in the intensive care unit: A comprehensive study involving socioeconomic status and resuscitation preferences*
Erickson, S. E., Vasilevskis, E. E., Kuzniewicz, M. W., Cason, B. A., Lane, R. K., Dean, M. L., Rennie, D. J., & Dudley, R. A. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e318206b3af · Cited by 76
Racial Disparities in Sepsis-Related In-Hospital Mortality: Using a Broad Case Capture Method and Multivariate Controls for Clinical and Hospital Variables, 2004–2013
Jones, J. M., Fingar, K. R., Miller, M. A., Coffey, R. M., Barrett, M. L., Flottemesch, T. J., Heslin, K. C., Gray, D. T., & Moy, E. M. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002699 · Cited by 74
The burden of invasive infections in critically ill Indigenous children in Australia
Ostrowski, J. A., MacLaren, G., Alexander, J., Stewart, P., Gune, S., Francis, J. R., Ganu, S. S., Festa, M., Erickson, S. J., Straney, L. D., et al. (2017) · The Medical Journal of Australia · doi:10.5694/mja16.00595 · Cited by 73
Vitamin D in sepsis: from basic science to clinical impact
Kempker, J. A., Tangpricha, V., Ziegler, T. R., & Martin, G. S. (2012) · Critical Care · doi:10.1186/cc11252 · Cited by 73
Hospital outcomes for children with severe sepsis in the USA by race or ethnicity and insurance status: a population-based, retrospective cohort study
Mitchell, H. K., Reddy, A. R., Montoya‐Williams, D., Harhay, M. O., Fowler, J., & Yehya, N. (2020) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(20)30341-2 · Cited by 72
The role of vitamin D deficiency in sepsis and potential therapeutic implications
Watkins, R., Yamshchikov, A. V., Lemonovich, T. L., & Salata, R. A. (2011) · Journal of Infection · doi:10.1016/j.jinf.2011.07.002 · Cited by 73
The Influence of Race/Ethnicity and Education on Family Ratings of the Quality of Dying in the ICU
Lee, J. J., Long, A. C., Curtis, J. R., & Engelberg, R. A. (2015) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2015.08.008 · Cited by 70
Defining Sepsis Mortality Clusters in the United States*
Moore, J. X., Donnelly, J. P., Griffin, R. L., Howard, G., Safford, M. M., & Wang, H. E. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001665 · Cited by 70
Exploring the pharmacological potential of promiscuous host-defense peptides: from natural screenings to biotechnological applications
Franco, O. L. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00232 · Cited by 70
Racial and Ethnic Disparities within and between Hospitals for Inpatient Quality of Care: An Examination of Patient-Level Hospital Quality Alliance Measures
Hasnain‐Wynia, R., Kang, R. H., Landrum, M. B., Vogeli, C., Baker, D. W., & Weissman, J. S. (2010) · Journal of Health Care for the Poor and Underserved · doi:10.1353/hpu.0.0281 · Cited by 71
Marital Status and the Epidemiology and Outcomes of Sepsis
Seymour, C. W., Iwashyna, T. J., Cooke, C. R., Hough, C. L., & Martin, G. S. (2010) · CHEST Journal · doi:10.1378/chest.09-2661 · Cited by 66
What is the best method for estimating the burden of severe sepsis in the United States?
Lagu, T. C., Rothberg, M. B., Shieh, M., Pekow, P. S., Steingrub, J. S., & Lindenauer, P. K. (2012) · Journal of Critical Care · doi:10.1016/j.jcrc.2012.02.004 · Cited by 65
Solar ultraviolet-B irradiance and vitamin D may reduce the risk of septicemia
Grant, W. B. (2009) · Dermato-Endocrinology · doi:10.4161/derm.1.1.7250 · Cited by 64
Transitions from short to long-term outcomes in pediatric critical care: considerations for clinical practice
Long, D. A., & Fink, E. L. (2021) · Translational Pediatrics · doi:10.21037/tp-21-61 · Cited by 66
Sepsis Visits and Antibiotic Utilization in U.S. Emergency Departments*
Filbin, M. R., Arias, S. A., Camargo, C. A., Barche, A., & Pallin, D. J. (2013) · Critical Care Medicine · doi:10.1097/ccm.0000000000000037 · Cited by 60
Quality Improvement Efforts Under Health Reform: How To Ensure That They Help Reduce Disparities—Not Increase Them
Weinick, R. M., & Hasnain‐Wynia, R. (2011) · Health Affairs · doi:10.1377/hlthaff.2011.0617 · Cited by 60
Racial Differences in Sepsis Recognition in the Emergency Department
Raman, J., Johnson, T. J., Hayes, K. L., & Balamuth, F. (2019) · PEDIATRICS · doi:10.1542/peds.2019-0348 · Cited by 59
Trends in empiric broad-Spectrum antibiotic use for suspected community-onset Sepsis in US hospitals
Rhee, C., Chen, T., Kadri, S. S., Lawandi, A., Yek, C., Walker, M., Warner, S., Fram, D., Chen, H.-C., Shappell, C. N., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.18923 · Cited by 58
Does SES explain more of the black/white health gap than we thought? Revisiting our approach toward understanding racial disparities in health
Phuong, D., Frank, R., & Finch, B. K. (2012) · Social Science & Medicine · doi:10.1016/j.socscimed.2011.12.048 · Cited by 57
Factors Underlying Racial Disparities in Sepsis Management
DiMeglio, M., Dubensky, J., Schadt, S., Potdar, R. R., & Laudański, K. (2018) · Healthcare · doi:10.3390/healthcare6040133 · Cited by 54
Association Between Socioeconomic Disadvantage and Decline in Function, Cognition, and Mental Health After Critical Illness Among Older Adults
Jain, S., Murphy, T. E., O’Leary, J. R., Leo-Summers, L. S., & Ferrante, L. E. (2022) · Annals of Internal Medicine · doi:10.7326/m21-3086 · Cited by 56
Association of neighborhood socioeconomic status with risk of infection and sepsis.
Donnelly, J. P., Lakkur, S., Judd, S. E., Levitan, E. B., Griffin, R., Howard, G., Safford, M. M., & Wang, H. E. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/cix1109 · Cited by 53
Patient and hospital characteristics associated with inpatient severe sepsis mortality in California, 2005–2010
Banta, J. E., Joshi, K. P., Beeson, L., & Nguyen, H. B. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e31825bc92f · Cited by 45
Epidemiology of sepsis in Korea: a population-based study of incidence, mortality, cost and risk factors for death in sepsis
Kim, J., Kim, K., Lee, H., & Ahn, S. (2019) · Clinical and Experimental Emergency Medicine · doi:10.15441/ceem.18.007 · Cited by 54
Risk factors for death after sepsis in patients immunosuppressed before the onset of sepsis
Poutsiaka, D. D., Davidson, L. E., Kahn, K. L., Bates, D. W., Snydman, D. R., & Hibberd, P. L. (2009) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540902962756 · Cited by 51
The effect of community socioeconomic status on sepsis-attributable mortality
Galiatsatos, P., Brigham, E. P., Pietri, J., Littleton, K., Hwang, S., Grant, M. C., Hansel, N. N., & Chen, E. S. (2018) · Journal of Critical Care · doi:10.1016/j.jcrc.2018.01.008 · Cited by 48
Resolvin D1 Promotes SIRT1 Expression to Counteract the Activation of STAT3 and NF-κB in Mice with Septic-Associated Lung Injury
Zhuo, Y., Zhang, S., Li, C., Yang, L., Gao, H., & Wang, X. (2018) · Inflammation · doi:10.1007/s10753-018-0819-2 · Cited by 52
Association of Household Income Level and In-Hospital Mortality in Patients With Sepsis: A Nationwide Retrospective Cohort Analysis
Rush, B. N. M., Wiskar, K., Celi, L. A., Walley, K. R., Russell, J. A., McDermid, R. C., & Boyd, J. H. (2017) · Journal of Intensive Care Medicine · doi:10.1177/0885066617703338 · Cited by 50
Ventilator Bundles in Transition: From Prevention of Ventilator-Associated Pneumonia to Prevention of Ventilator-Associated Events
Kallet, R. H. (2019) · Respiratory Care · doi:10.4187/respcare.06966 · Cited by 53
The Association between Limited English Proficiency and Sepsis Mortality
Jacobs, Z. G., Prasad, P. A., Fang, M. C., Abe‐Jones, Y., & Kangelaris, K. N. (2019) · Journal of Hospital Medicine · doi:10.12788/jhm.3334 · Cited by 49
Sepsis-Related Mortality Rates and Trends Based on Site of Infection
Prest, J., Nguyen, T., Rajah, T., Prest, A. B., Sathananthan, M., & Jeganathan, N. (2022) · Critical Care Explorations · doi:10.1097/cce.0000000000000775 · Cited by 47
Contemporary Trends of the Epidemiology, Clinical Characteristics, and Resource Utilization of Necrotizing Fasciitis in Texas: A Population-Based Cohort Study
Oud, L., & Watkins, P. (2015) · Critical Care Research and Practice · doi:10.1155/2015/618067 · Cited by 46
Diagnostic utility of LightCycler SeptiFast and procalcitonin assays in the diagnosis of bloodstream infection in immunocompromised patients
Mauro, M. V., Cavalcanti, P., Perugini, D., Noto, A., Sperlì, D., & Giraldi, C. (2012) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2012.04.006 · Cited by 44
Human recombinant activated protein C for severe sepsis
Martí-Carvajal, A. J., Solà, I., Lathyris, D., & Cardona, A. F. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004388.pub4 · Cited by 44
Mortality Among Black Men in the USA
Pathak, E. B. (2017) · Journal of Racial and Ethnic Health Disparities · doi:10.1007/s40615-017-0341-5 · Cited by 44
Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials*
Cooke, C. R., Erickson, S. E., Watkins, T. R., Matthay, M. A., Hudson, L. D., & Rubenfeld, G. D. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181de451b · Cited by 44
Racial And Ethnic Disparities In Care Following The New York State Sepsis Initiative
Corl, K. A., Levy, M. M., Phillips, G. S., Terry, K. M., Friedrich, M. E., & Trivedi, A. N. (2019) · Health Affairs · doi:10.1377/hlthaff.2018.05381 · Cited by 42
Trends in the incidence of noncardiogenic acute respiratory failure
Cooke, C. R., Erickson, S. E., Eisner, M. D., & Martin, G. S. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e31824518f2 · Cited by 41
Black-white racial disparities in sepsis: a prospective analysis of the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort
Moore, J. X., Donnelly, J. P., Griffin, R. L., Safford, M. M., Howard, G., Baddley, J. W., & Wang, H. E. (2015) · Critical Care · doi:10.1186/s13054-015-0992-8 · Cited by 41
Clostridium difficile infection health disparities by race among hospitalized adults in the United States, 2001 to 2010
Argamany, J. R., Delgado, A., & Reveles, K. R. (2016) · BMC Infectious Diseases · doi:10.1186/s12879-016-1788-4 · Cited by 41
Socioeconomic Factors and Intensive Care Unit-Related Cognitive Impairment
Haddad, D. N., Mart, M. F., Wang, L., Lindsell, C. J., Chandrasekhar, R., Nordness, M. F., Sharp, K. W., Pandharipande, P. P., Girard, T. D., Ely, E. W., et al. (2020) · Annals of Surgery · doi:10.1097/sla.0000000000004377 · Cited by 42
A prospective study of cancer survivors and risk of sepsis within the REGARDS cohort
Moore, J. X., Akinyemiju, T., Bartolucci, A. A., Wang, H. E., Waterbor, J. W., & Griffin, R. L. (2018) · Cancer Epidemiology · doi:10.1016/j.canep.2018.05.001 · Cited by 39
P2X4 receptors, immunity, and sepsis
Antonioli, L., Blandizzi, C., Fornai, M., Pacher, P., Lee, H. T., & Haskó, G. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.02.011 · Cited by 40
Racial Differences in Sepsis Mortality at U.S. Academic Medical Center–Affiliated Hospitals*
Chaudhary, N. S., Donnelly, J. P., & Wang, H. E. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003020 · Cited by 38
Sepsis with liver dysfunction and coagulopathy predicts an inflammatory pattern of macrophage activation
Anderko, R. R., Gómez, H., Canna, S., Shakoory, B., Angus, D. C., Yealy, D. M., Huang, D. T., Kellum, J. A., Carcillo, J. A., For the ProCESS Investigators, et al. (2022) · Intensive Care Medicine Experimental · doi:10.1186/s40635-022-00433-y · Cited by 37
Self-citation
Validation of the Riboleukogram to Detect Ventilator-Associated Pneumonia After Severe Injury
Cobb, J. P., Moore, E. E., Hayden, D. L., Minei, J. P., Cuschieri, J., Yang, J., Li, Q., Lin, N., Brownstein, B. H., Hennessy, L. V., et al. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e3181b8fbd5 · Cited by 38
Racial and Geographic Disparities in Interhospital ICU Transfers*
Tyler, P. D., Stone, D. J., Geisler, B. P., McLennan, S., Celi, L. A., & Rush, B. N. M. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002776 · Cited by 37
Association between lymphotoxin-α (tumor necrosis factor-β) intron polymorphism and predisposition to severe sepsis is modified by gender and age
Watanabe, E., Buchman, T. G., Hirasawa, H., & Zehnbauer, B. A. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181bc805d · Cited by 35
Frailty Syndrome and Risk of Sepsis in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Cohort
Mahalingam, M., Moore, J. X., Donnelly, J. P., Safford, M. M., & Wang, H. E. (2017) · Journal of Intensive Care Medicine · doi:10.1177/0885066617715251 · Cited by 33
The Impact of Chronic Ozone and Particulate Air Pollution on Mortality in Patients With Sepsis Across the United States
Rush, B. N. M., Wiskar, K., Fruhstorfer, C., Celi, L. A., & Walley, K. R. (2018) · Journal of Intensive Care Medicine · doi:10.1177/0885066618804497 · Cited by 34
Health Disparities and Sepsis: a Systematic Review and Meta-Analysis on the Influence of Race on Sepsis-Related Mortality
Galiatsatos, P., Sun, J., Welsh, J. A., & Suffredini, A. F. (2019) · Journal of Racial and Ethnic Health Disparities · doi:10.1007/s40615-019-00590-z · Cited by 32
Impact of Socioeconomic Status and Race on Sepsis Epidemiology and Outcomes
Minejima, E., & Wong‐Beringer, A. (2020) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfaa151 · Cited by 32
Update and Review of Racial Disparities in Sepsis
Vogel, T. R. (2012) · Surgical Infections · doi:10.1089/sur.2012.124 · Cited by 32
Racial Disparities in Length of Stay Among Severely Ill Patients Presenting With Sepsis and Acute Respiratory Failure
Chesley, C. F., Chowdhury, M., Small, D. S., Schaubel, D. E., Liu, V. X., Lane-Fall, M. B., Halpern, S. D., & Anesi, G. L. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.9739 · Cited by 32
Humoral immune response to abnormal MUC1 in subjects with colorectal adenoma and cancer
Silk, A. W., Schoen, R. E., Potter, D. M., & Finn, O. J. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2008.12.025 · Cited by 31
Relationship Between African-American Race and Delirium in the ICU
Khan, B. A., Perkins, A. J., Hui, S. L., Gao, S., Campbell, N. L., Farber, M. O., & Boustani, M. A. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001813 · Cited by 31
Linking Sepsis with chronic arterial hypertension, diabetes mellitus, and socioeconomic factors in the United States: A scoping review
Ahlberg, C. D., Wallam, S., Tirba, L. A., Itumba, S. N., Gorman, L., & Galiatsatos, P. (2023) · Journal of Critical Care · doi:10.1016/j.jcrc.2023.154324 · Cited by 30
Trends and Outcomes in Sepsis Hospitalizations With and Without Atrial Fibrillation: A Nationwide Inpatient Analysis
Desai, R., Hanna, B., Singh, S., Omar, A., Deshmukh, A. J., Kumar, G., Foreman, M. G., & Sachdeva, R. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000003806 · Cited by 30
Hospital Differences Drive Antibiotic Delays for Black Patients Compared With White Patients With Suspected Septic Shock
Taylor, S. P., Karvetski, C., Templin, M. A., & Taylor, B. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002829 · Cited by 29
Variation in the care of septic shock: The impact of patient and hospital characteristics
Lagu, T. C., Rothberg, M. B., Nathanson, B. H., Pekow, P. S., Steingrub, J. S., & Lindenauer, P. K. (2012) · Journal of Critical Care · doi:10.1016/j.jcrc.2011.12.003 · Cited by 28
Risk Factors for Septicemia Deaths and Disparities in a Longitudinal US Cohort
Kempker, J. A., Kramer, M. R., Waller, L. A., & Martin, G. S. (2018) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofy305 · Cited by 27

Authors: Barnato, A. E., Alexander, S. L., Linde-Zwirble, W. T., & Angus, D. C.
Affiliations: University of Pittsburgh (US)
Genentech (US)
ZD Associates, LLC, Perkasie, Pennsylvania
ORCID: Barnato, Amber E.
Angus, Derek C.
Venue: American Journal of Respiratory and Critical Care Medicine
Publisher: Oxford University Press (OUP)
Published: 2008-02-01
Volume: 177
Issue: 3
Pages: 279-284
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/rccm.200703-480oc
PMC: PMC2720103
OpenAlex: W2000321839
Cited by: 284
References: 31
Citations by year: 2026: 15 · 2025: 19 · 2024: 16 · 2023: 23 · 2022: 22 · 2021: 14 · 2020: 13 · 2019: 16 · 2018: 14 · 2017: 13 · 2016: 24 · 2015: 12 · 2014: 6 · 2013: 8 · 2012: 18
FWCI: 9.21
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (K08 AG 21921, K08AG021921)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Social Sciences › Health › Health disparities and outcomes
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
Keywords: severe sepsis, racial disparities, Black patients, Hispanic patients, case fatality, sepsis incidence, intensive care unit admission, poverty, health care disparities, residual confounding, hospital quality of care
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Black or African American, Child, Child, Preschool, Critical Care, Female, Hispanic or Latino, Hospital Bed Capacity, Hospitals, Teaching, Hospitals, Urban, Humans, Infant, Infant, Newborn, Intensive Care Units, Male, Middle Aged, Practice Patterns, Physicians', Retrospective Studies, United States, Cohort Studies, Incidence, Sepsis, White People, Health Status Disparities, Healthcare Disparities

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Racial Variation in the Incidence, Care, and Outcomes of Severe Sepsis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks