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Cited by 1,317

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children

Open access
Jackson, Daniel J., Gangnon, Ronald E., Evans, Michael D., Roberg, Kathy A., Anderson, Elizabeth L., Pappas, Tressa E., Printz, Magnolia C., Lee, Wai-Ming, Shult, Peter A., Reisdorf, Erik, Carlson-Dakes, Kirsten T., Salazar, Lisa P., DaSilva, Douglas F., Tisler, Christopher J., Gern, James E., Lemanske, Robert F.·2008·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.200802-309oc
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Abstract

RATIONALE: Virus-induced wheezing episodes in infancy often precede the development of asthma. Whether infections with specific viral pathogens confer differential future asthma risk is incompletely understood. OBJECTIVES: To define the relationship between specific viral illnesses and early childhood asthma development. METHODS: A total of 259 children were followed prospectively from birth to 6 years of age. The etiology and timing of specific viral wheezing respiratory illnesses during early childhood were assessed using nasal lavage, culture, and multiplex reverse transcriptase-polymerase chain reaction. The relationships of these virus-specific wheezing illnesses and other risk factors to the development of asthma were analyzed. MEASUREMENTS AND MAIN RESULTS: Viral etiologies were identified in 90% of wheezing illnesses. From birth to age 3 years, wheezing with respiratory syncytial virus (RSV) (odds ratio [OR], 2.6), rhinovirus (RV) (OR, 9.8), or both RV and RSV (OR , 10) was associated with increased asthma risk at age 6 years. In Year 1, both RV wheezing (OR, 2.8) and aeroallergen sensitization (OR, 3.6) independently increased asthma risk at age 6 years. By age 3 years, wheezing with RV (OR, 25.6) was more strongly associated with asthma at age 6 years than aeroallergen sensitization (OR, 3.4). Nearly 90% (26 of 30) of children who wheezed with RV in Year 3 had asthma at 6 years of age. CONCLUSIONS: Among outpatient viral wheezing illnesses in infancy and early childhood, those caused by RV infections are the most significant predictors of the subsequent development of asthma at age 6 years in a high-risk birth cohort.

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Metadata

Authors
Jackson, D. J., Gangnon, R. E., Evans, M. D., Roberg, K. A., Anderson, E. L., Pappas, T. E., Printz, M. C., Lee, W.-M., Shult, P. A., Reisdorf, E., Carlson-Dakes, K. T., Salazar, L. P., DaSilva, D. F., Tisler, C. J., Gern, J. E., & Lemanske, R. F.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2008-10-01
Volume
178
Issue
7
Pages
667-672
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.200802-309oc
OpenAlex
W2125178177
Cited by
1,317
References
20
FWCI
48.46
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children. https://app.cochat.ai/papers/10.1164/rccm.200802-309oc
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Jackson, D. J., Gangnon, R. E., Evans, M. D., Roberg, K. A., Anderson, E. L., Pappas, T. E., Printz, M. C., Lee, W.-M., Shult, P. A., Reisdorf, E., Carlson-Dakes, K. T., Salazar, L. P., DaSilva, D. F., Tisler, C. J., Gern, J. E., & Lemanske, R. F. (2008). Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200802-309oc

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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