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Peripheral Blood Proteins Predict Mortality in Idiopathic Pulmonary Fibrosis
Open accessAbstract
Rationale: Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology with a variable and unpredictable course. Objectives: The aim of this study was to identify and validate plasma proteins that are predictive of outcome in IPF. Methods: Plasma samples were available for 241 patients with IPF (140 derivation and 101 validation). In the derivation cohort, concentrations of 92 proteins were analyzed using a multiplex bead-based immunoassay and concentrations of matrix metalloproteinase (MMP)-7, MMP-1, and surfactant protein D were assessed by ELISA. In the validation cohort concentrations of intercellular adhesion molecule (ICAM)-1, IL-8, and vascular cell adhesion molecule (VCAM)-1 were assessed by bead-based multiplex assay, and S100A12 and MMP-7 by ELISA. Associations of biomarkers with mortality, transplant-free survival, and disease progression were tested in the derivation and validation cohorts using nonparametric methods of survival analysis and the Cox proportional hazards model, and an integrated risk prediction score was derived and tested. Measurements and Main Results: High concentrations of MMP-7, ICAM-1, IL-8, VCAM-1, and S100A12 predicted poor overall survival, poor transplant-free survival, and poor progression-free survival in the derivation cohort. In the independent validation cohort high concentrations of all five were predictive of poor transplant-free survival; MMP-7, ICAM-1, and IL-8 of overall survival; and ICAM-1 of poor progression-free survival. The personal clinical and molecular mortality prediction index derived in the derivation cohort was highly predictive of mortality in the validation cohort. Conclusions: Our results suggest that plasma proteins should be evaluated as a tool for prognosis determination in prioritization of patients for lung transplantation and stratification in drug studies.
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“High plasma concentrations of MMP7, vascular cell adhesion molecule (VCAM)-1, S100A12, intercellular adhesion molecule (ICAM)1, and IL-8 predicted poor overall survival, transplant-free survival, and progression-free survival in an IPF derivation cohort of 141 patients, while all five were predictive of poor transplant-free survival; MMP7, ICAM-1, and IL-8 of over”
From Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies (2023) · cites this paper as Richards et al., 2012
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Cites
Modern Applied Statistics with S
Venables, W. N., & Ripley, B. D. (2002) · Statisctics and computing/Statistics and computing · doi:10.1007/978-0-387-21706-2 · Cited by 25,941
Gentleman R: R: A language for data analysis and graphics
Ihaka, R., & Gentleman, R. (1996) · Journal of Computational and Graphical Statistics · doi:10.1080/10618600.1996.10474713 · Cited by 11,747
Modeling Survival Data: Extending the Cox Model
Therneau, T. M., & Grambsch, P. M. (2000) · Statistics for Biology and Health · doi:10.1007/978-1-4757-3294-8 · Cited by 8,674
Time‐Dependent ROC Curves for Censored Survival Data and a Diagnostic Marker
Heagerty, P. J., Lumley, T., & PEPE, M. S. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00337.x · Cited by 2,870
Krämer, W. (2003) · Computational Statistics & Data Analysis · Cited by 1,858
Selman, M., King, T. E., & Pardo, A. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-2-200101160-00015 · Cited by 1,807
Clinical course and prediction of survival in idiopathic pulmonary fibrosis
Ley, B., Collard, H. R., & King, T. E. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201006-0894ci · Cited by 1,765
Uno, H., Cai, T., Pencina, M. J., D'Agostino, R. B., & Wei, L. J. (2011) · Statistics in Medicine · doi:10.1002/sim.4154 · Cited by 1,535
Willis, B. C., Liebler, J. M., Luby‐Phelps, K., Nicholson, A. G., Crandall, E. D., du Bois, R. M., & Borok, Z. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62351-6 · Cited by 973
Predicting Survival in Idiopathic Pulmonary Fibrosis
KING, T. E., TOOZE, J. A., SCHWARZ, M. I., BROWN, K. R., & CHERNIACK, R. M. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.7.2003140 · Cited by 853
NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury
Hecker, L., Vittal, R., Jones, T., Jagirdar, R., Luckhardt, T. R., Horowitz, J. C., Pennathur, S., Martinez, F. J., & Thannickal, V. J. (2009) · Nature Medicine · doi:10.1038/nm.2005 · Cited by 852
Li, Q., Park, P. W., Wilson, C. L., & Parks, W. C. (2002) · Cell · doi:10.1016/s0092-8674(02)01079-6 · Cited by 752
Murphy, S. A., & Van Der Vaart, A. W. (2000) · Journal of the American Statistical Association · doi:10.1080/01621459.2000.10474219 · Cited by 712
Aberrant Wnt/β-Catenin Pathway Activation in Idiopathic Pulmonary Fibrosis
Chilosi, M., Poletti, V., Zamò, A., Lestani, M., Montagna, L., Piccoli, P., Pedron, S., Bertaso, M., Scarpa, A., Murer, B., et al. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64282-4 · Cited by 708
Wells, A. U., Desai, S. R., Rubens, M. B., Goh, N. S. L., Cramer, D., Nicholson, A. G., Colby, T. V., du Bois, R. M., & Hansell, D. M. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2111053 · Cited by 686
King, T. E., Schwarz, M. I., Brown, K. M., Tooze, J. A., Colby, T. V., Waldron, J. A., Flint, A., Thurlbeck, W. M., & Cherniack, R. M. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.6.2001056 · Cited by 629
The Clinical Course of Patients with Idiopathic Pulmonary Fibrosis
Martinez, F. J., Safrin, S., Weycker, D., Starko, K. M., Bradford, W. Z., King, T. E., Flaherty, K. R., Schwartz, D. A., Noble, P. W., Raghu, G., et al. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-12_part_1-200506210-00005 · Cited by 622
Zuo, F., Kaminski, N., Eugui, E. M., Allard, J. D., Zohar Yakhini, B., Ben‐Dor, A., Lollini, L. O., Morris, D. G., Kim, Y., DeLustro, B., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092134099 · Cited by 620
Self-citationMMP1 and MMP7 as Potential Peripheral Blood Biomarkers in Idiopathic Pulmonary Fibrosis
Rosas, I. O., Richards, T. J., Konishi, K., Zhang, Y., Gibson, K., Lokshin, A. E., Lindell, K. O., Cisneros, J., MacDonald, S. D., Pardo, A., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050093 · Cited by 582
Self-citationKönigshoff, M., Kramer, M., Balsara, N., Wilhelm, J., Amarie, O. V., Jahn, A., Rose, F., Fink, L., Seeger, W., Schaefer, L., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci33950 · Cited by 558
Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis
Königshoff, M., Balsara, N., Pfaff, E.-M., Kramer, M., Chrobak, I., Seeger, W., & Eickelberg, O. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002142 · Cited by 511
Incidence, Prevalence, and Clinical Course of Idiopathic Pulmonary Fibrosis
Pérez, E. R. F., Daniels, C. E., Sauver, J. L. S., Hartman, T. E., Bartholmai, B. J., Yi, E. S., Ryu, J. H., & Schroeder, D. R. (2009) · CHEST Journal · doi:10.1378/chest.09-1002 · Cited by 508
Nicholson, A. G., Colby, T. V., du Bois, R. M., Hansell, D. M., & Wells, A. U. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.6.2003049 · Cited by 489
Demedts, M., & Costabel, U. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00492002 · Cited by 460
Clinical and Pathologic Features of Familial Interstitial Pneumonia
Steele, M. P., Speer, M. C., Loyd, J. E., Brown, K. K., Herron, A., Slifer, S. H., Burch, L. H., Wahidi, M. M., Phillips, J. A., Sporn, T. A., et al. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200408-1104oc · Cited by 432
Ascertainment of Individual Risk of Mortality for Patients with Idiopathic Pulmonary Fibrosis
du Bois, R. M., Weycker, D. A., Albera, C., Bradford, W. Z., Costabel, U., Kartashov, A. I., LANCASTER, L. H., Noble, P. W., Raghu, G., Sahn, S. A., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201011-1790oc · Cited by 428
Meltzer, E. B., & Noble, P. W. (2008) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-3-8 · Cited by 421
Clinical significance of histological classification of idiopathic interstitial pneumonia
Flaherty, K. R., Toews, G. B., Travis, W. D., Colby, T. V., Kazerooni, E. A., Gross, B. H., Jain, A. K., Strawderman, R. L., Paine, R., Flint, A., et al. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00182002 · Cited by 371
Idiopathic Pulmonary Fibrosis: Aberrant Recapitulation of Developmental Programs?
Selman, M., Pardo, A., & Kaminski, N. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050062 · Cited by 342
Self-citationGene Expression Profiles of Acute Exacerbations of Idiopathic Pulmonary Fibrosis
Konishi, K., Gibson, K. F., Lindell, K. O., Richards, T. J., Zhang, Y., Dhir, R., Bisceglia, M., Gilbert, S., Yousem, S. A., Song, J. W., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200810-1596oc · Cited by 337
Self-citationSerum CC-Chemokine Ligand 18 Concentration Predicts Outcome in Idiopathic Pulmonary Fibrosis
Prasse, A., Probst, C., Bargagli, E., Zissel, G., Toews, G. B., Flaherty, K. R., Olschewski, M., Rottoli, P., & Müller–Quernheim, J. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200808-1201oc · Cited by 331
McGuire, J. K., Li, Q., & Parks, W. C. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64318-0 · Cited by 323
Prognostic value of circulating KL‐6 in idiopathic pulmonary fibrosis
Yokoyama, A., KONDO, K., Nakajima, M., Matsushima, T., Takahashi, T., Nishimura, M., Bando, M., Sugiyama, Y., Totani, Y., Ishizaki, T., et al. (2006) · Respirology · doi:10.1111/j.1440-1843.2006.00834.x · Cited by 304
Accelerated Variant of Idiopathic Pulmonary Fibrosis: Clinical Behavior and Gene Expression Pattern
Selman, M., Carrillo, G., Estrada, A., Mejía, M. E., Becerril, C., Cisneros, J., Gaxiola, M., Pérez‐Padilla, R., Navarro, C., Richards, T. J., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000482 · Cited by 274
Self-citationCarré, P. C., Mortenson, R. L., King, T. E., Noble, P. W., Sable, C. L., & Riches, D. W. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115501 · Cited by 253
Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis
Kliment, C. R., & Oury, T. D. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.036 · Cited by 236
Oxidative stress in the pathogenesis of diffuse lung diseases: A review
Bargagli, E., Olivieri, C., Bennett, D., Prasse, A., Müller–Quernheim, J., & Rottoli, P. (2009) · Respiratory Medicine · doi:10.1016/j.rmed.2009.04.014 · Cited by 216
WNT5A Is a Regulator of Fibroblast Proliferation and Resistance to Apoptosis
Vuga, L. J., Ben‐Yehudah, A., Kovkarova-Naumovski, E., Oriss, T. B., Gibson, K. F., Feghali‐Bostwick, C. A., & Kaminski, N. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0201oc · Cited by 215
Self-citationSerum Surfactant Protein-A Is a Strong Predictor of Early Mortality in Idiopathic Pulmonary Fibrosis
Kinder, B. W., Brown, K. K., McCormack, F. X., Ix, J. H., Kervitsky, A., Schwarz, M. I., & King, T. E. (2009) · CHEST Journal · doi:10.1378/chest.08-2209 · Cited by 211
Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis
Collard, H. R., Calfee, C. S., Wolters, P. J., Song, J. W., Hong, S., Brady, S. E., Ishizaka, A., Jones, K. D., King, T. E., Matthay, M. A., et al. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90637.2008 · Cited by 191
NOX Enzymes and Pulmonary Disease
Griffith, B. D., Pendyala, S., Hecker, L., Lee, P. J., Natarajan, V., & Thannickal, V. J. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2599 · Cited by 156
Pathogenesis and Natural History of Usual Interstitial Pneumonia
Strieter, R. M. (2005) · CHEST Journal · doi:10.1378/chest.128.5_suppl_1.526s · Cited by 129
IPF: new insight on pathogenesis and treatment
Harari, S. A., & Caminati, A. (2010) · Allergy · doi:10.1111/j.1398-9995.2009.02305.x · Cited by 119
Lung function in idiopathic pulmonary fibrosis - extended analyses of the IFIGENIA trial
the Ifigenia study group*, Behr, J., Demedts, M., Buhl, R., Costabel, U., Dekhuijzen, R. P. N., Jansen, H. M., MacNee, W., Thomeer, M., Wallaert, B., et al. (2009) · Respiratory Research · doi:10.1186/1465-9921-10-101 · Cited by 96
Yogo, Y., Fujishima, S., Inoue, T., Saito, F., Shiomi, T., Yamaguchi, K., & Ishizaka, A. (2009) · Respiratory Research · doi:10.1186/1465-9921-10-80 · Cited by 91
Epperly, M. W., Sikora, C. A., DeFilippi, S. J., Gretton, J. E., Bar‐Sagi, D., Archer, H., Carlos, T. M., Guo, H., & Greenberger, J. S. (2002) · Transplantation and Cellular Therapy · doi:10.1053/bbmt.2002.v8.pm12014807 · Cited by 91
Fujishima, S., Shiomi, T., Yamashita, S., Yogo, Y., Nakano, Y., Inoue, T., Nakamura, M., Tasaka, S., Hasegawa, N., Aikawa, N., et al. (2010) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2009-0144-oa.1 · Cited by 88
Non‐invasive biomarkers in pulmonary fibrosis
Prasse, A., & Müller–Quernheim, J. (2009) · Respirology · doi:10.1111/j.1440-1843.2009.01600.x · Cited by 72
Matrix metalloproteinase-7 (matrilysin) controls neutrophil egress by generating chemokine gradients
Swee, M., Wilson, C. L., Wang, Y., McGuire, J. K., & Parks, W. C. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0108016 · Cited by 70
Maeyama, T., Kuwano, K., Kawasaki, M., Kunitake, R., Hagimoto, N., Matsuba, T., Yoshimi, M., Inoshima, I., Yoshida, K., & Hara, N. (2001) · European Respiratory Journal · doi:10.1183/09031936.01.17201800 · Cited by 68
Differential Processing of α- and β-Defensin Precursors by Matrix Metalloproteinase-7 (MMP-7)
Wilson, C. L., Schmidt, A. P., Pirilä, E., Valore, E. V., Ferri, N., Sorsa, T. A., Ganz, T., & Parks, W. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809744200 · Cited by 60
Radomska-Leśniewska, D. M., Skopińska-Różewska, E., Jankowska-Steifer, E. A., Sobiecka, M., Sadowska, A. M., Hevelke, A., & Malejczyk, J. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70250-4 · Cited by 52
Sato, N., Suzuki, Y., Nishio, K., Suzuki, K., Naoki, K., Takeshita, K., Kudo, H., Miyao, N., Tsumura, H., Serizawa, H., et al. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.5.9907104 · Cited by 50
Ihn, H. (1997) · British journal of rheumatology · doi:10.1093/rheumatology/36.12.1270 · Cited by 46
Expression of Cell Adhesion Molecules in the Lungs of Patients With Idiopathic Pulmonary Fibrosis
Nakao, A., Hasegawa, Y., Tsuchiya, Y., & Shimokata, K. (1995) · CHEST Journal · doi:10.1378/chest.108.1.233 · Cited by 45
Xaubet, A., Agustı́, C., Luburich, P., Barberà, J. A., Carrión, M. T., Ayuso, C., Roca, J., & Rodríguez-Roisin, R. (1998) · Respiratory Medicine · doi:10.1016/s0954-6111(98)90118-4 · Cited by 42
Radomska-Leśniewska, D. M., Sadowska, A. M., van Overveld, F. J., Demkow, U. A., Zielinski, J., & Backer, W. D. (2006) · PubMed · Cited by 42
Bouwman, F. G., de Roos, B., Rubio‐Aliaga, I., Crosley, L. K., Duthie, S. J., Mayer, C., Horgan, G. W., Polley, A. C. J., Heim, C., Coort, S. L., et al. (2011) · BMC Medical Genomics · doi:10.1186/1755-8794-4-24 · Cited by 37
Sadowska, A. M., Manuel‐y‐Keenoy, B., Vertongen, T., Schippers, G., Radomska-Leśniewska, D. M., Heytens, E., & Backer, W. A. D. (2005) · Pharmacological Research · doi:10.1016/j.phrs.2005.11.003 · Cited by 36
Kikkawa, T., Sato, N., Kojika, M., Takahashi, G., Aoki, K., Hoshikawa, K., Akitomi, S., Shozushima, T., Suzuki, K., Wakabayashi, G., et al. (2010) · Digestive Surgery · doi:10.1159/000313687 · Cited by 33
Idiopathic pulmonary fibrosis: treatment options in pursuit of evidence-based approaches
Raghu, G. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00086606 · Cited by 24
Epperly, M. W., Guo, H., Shields, D. S., Zhang, X., & Greenberger, J. S. (2004) · PubMed · Cited by 21
Bleomycin induces IL-8 and ICAM-1 expression in microvascular pulmonary endothelial cells
Fichtner, F., Koslowski, R., Augstein, A., Hempel, U., Roehlecke, C., & Kasper, M. E. (2004) · Experimental and Toxicologic Pathology · doi:10.1078/0940-2993-00345 · Cited by 20
CXC chemokines in vascular remodeling related to pulmonary fibrosis.
Strieter, R. M., Belperio, J. A., & Keane, M. P. (2003) · PubMed · Cited by 15
Intercellular adhesion molecule-1 in patients with idiopathic interstitial pneumonia.
Takehara, H., Tada, S., Kataoka, M., Matsuo, K., Ueno, Y., Ozaki, S., Miyake, T., Fujimori, Y., Yamadori, I., & Harada, M. (2001) · PubMed · doi:10.18926/amo/31991 · Cited by 10
Peripheral Blood Biomarkers Predict Disease Progression And Mortality In IPF
Richards, T. J., Lindell, K. O., Klesen, M. J., Kaminski, N., Zhang, Y., & Gibson, K. F. (2010) · doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1120 · Cited by 3
Self-citationWells, A. U., Richards, T. J., & Martínez, F. J. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201107-1216ed · Cited by 2
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Metadata
- Authors
- Richards, T. J., Kaminski, N., Baribaud, F., Flavin, S., Brodmerkel, C., Horowitz, D., Li, K., Choi, J., Vuga, L. J., Lindell, K. O., Klesen, M., Zhang, Y., & Gibson, K. F.
- Affiliations
- University of Pittsburgh (US)
- Centocor R&D Inc., Radnor, Pennsylvania
- Corresponding author
- Gibson, Kevin F.
- ORCID
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-01-01
- Volume
- 185
- Issue
- 1
- Pages
- 67-76
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- PMC
- PMC3262037
- OpenAlex
- W2007414618
- Cited by
- 381
- References
- 67
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 18 · 2023: 26 · 2022: 20 · 2021: 23 · 2020: 27 · 2019: 22 · 2018: 31 · 2017: 30 · 2016: 27 · 2015: 40 · 2014: 30 · 2013: 35 · 2012: 28
- FWCI
- 25.85
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P50 HL0894932, R01HL095397)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Keywords
- idiopathic pulmonary fibrosis, plasma biomarkers, mortality prediction, MMP-7, ICAM-1, interleukin-8, VCAM-1, S100A12, surfactant protein D, transplant-free survival, progression-free survival, risk scoring, disease progression
- MeSH terms
- S100A12 Protein, Aged, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, S100 Proteins, Predictive Value of Tests, Cohort Studies, Biomarkers, Cell Adhesion Molecules, Proportional Hazards Models, Survival Analysis, Interleukin-8, Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, Matrix Metalloproteinase 1, Matrix Metalloproteinases, Matrix Metalloproteinase 7, Idiopathic Pulmonary Fibrosis
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