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Role of Disease and Macronutrient Dose in the Randomized Controlled EPaNIC Trial
Open accessAbstract
Rationale: Early parenteral nutrition to supplement insufficient enteral feeding during intensive care (early PN) delays recovery as compared with withholding parenteral nutrition for 1 week (late PN). Objectives: To assess whether deleterious effects of early PN relate to severity of illness or to the dose or type of macronutrients. Methods: Secondary analyses of a randomized controlled trial (EPaNIC; n = 4,640) performed in seven intensive care units from three departments in two Belgian hospitals. In part 1, all patients were included to assess the effect of the randomized allocation to early PN or late PN in subgroups of patients with increasing-on-admission severity of illness. In part 2, observationally, the association of the amount and type of macronutrients with recovery was documented in those patient cohorts still present in intensive care on Days 3, 5, 7, 10, and 14. Measurements and Main Results: The primary end point was time to live discharge from the intensive care unit. For part 1, a secondary end point, acquisition of new infections, was also analyzed. All statistical analyses were performed by univariable and adjusted multivariable methods. In none of the subgroups defined by type or severity of illness was a beneficial effect of early PN observed. The lowest dose of macronutrients was associated with the fastest recovery and any higher dose, administered parenterally or enterally, was associated with progressively more delayed recovery. The amount of proteins/amino acids rather than of glucose appeared to explain delayed recovery with early feeding. Conclusions: Early combined parenteral/enteral nutrition delayed recovery irrespective of severity of critical illness. No dose or type of macronutrient was found to be associated with improved outcome. Clinical trial registered with www.clinicaltrials.gov (NCT00512122).
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“Higher protein intakes during the acute phase might be linked to greater muscle wasting and ICU-acquired weakness.1,15”
From Low versus standard calorie and protein feeding in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3). (2023) · cites this paper as [15]
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“A post hoc analysis of this trial suggested that the highest amount of nutritional intake was associated with a higher infection rate and a delay in recovery [37].”
From Nutrition in Sepsis: A Bench-to-Bedside Review. (2020) · cites this paper as [37]
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“In addition, the post hoc analysis of EPaNIC (173, 174) studies suggested that early administration of amino acids (mainly at day 3) was associated with a later live discharge from the ICU, questioning the indication of administrating amino acids in the early stay in the ICU (175).”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [174]
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Cites
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985) · Critical Care Medicine · doi:10.1097/00003246-198510000-00009 · Cited by 15,518
APACHE II-A Severity of Disease Classification System
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00028 · Cited by 13,379
ESPEN Guidelines for Nutrition Screening 2002
Kondrup, J. (2003) · Clinical Nutrition · doi:10.1016/s0261-5614(03)00098-0 · Cited by 3,159
ESPEN guidelines on parenteral nutrition: intensive care
Singer, P., Berger, M. M., Van den Berghe, G., Biolo, G., Calder, P., Forbes, A., Griffiths, R., Kreyman, G., Leverve, X., & Pichard, C. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.04.024 · Cited by 1,907
Early versus late parenteral nutrition in critically ill adults
Casaer, M. P., Mesotten, D., Hermans, G., Wouters, P. J., Schetz, M., Meyfroidt, G., Van Cromphaut, S., Ingels, C., Meersseman, P., Muller, J., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1102662 · Cited by 1,696
Self-citationTaylor, B. E., McClave, S. A., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001525 · Cited by 1,476
ESPEN guidelines on enteral nutrition: intensive care
Kreymann, K. G., Berger, M. M., Deutz, N. E. P., Hiesmayr, M., Jolliet, P., Kazandjiev, G., Nitenberg, G., van den Berghe, G., Wernerman, J., Ebner, C., et al. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.01.021 · Cited by 1,366
Autophagy is required to maintain muscle mass.
Masiero, E., Agatea, L., Mammucari, C., Blaauw, B., Loro, E., Komatsu, M., Metzger, D., Reggiani, C., Schiaffino, S., & Sandri, M. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.008 · Cited by 1,282
Negative impact of hypocaloric feeding and energy balance on clinical outcome in ICU patients
Villet, S., Chiolero, R. L., Bollmann, M. D., Revelly, J.-P., Cayeux RN, M.-C., Delarue, J., & Berger, M. M. (2005) · Clinical Nutrition · doi:10.1016/j.clnu.2005.03.006 · Cited by 995
Alberda, C., Gramlich, L., Jones, N., Jeejeebhoy, K., Day, A. G., Dhaliwal, R., & Heyland, D. K. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1567-4 · Cited by 975
The National Heart, L., Rice, T. W., Wheeler, A. P., Thompson, B. T., Steingrub, J., Hite, R. D., Moss, M., Morris, A., Dong, N., & Rock, P. (2012) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.2012.137 · Cited by 935
Singer, P., Anbar, R., Cohen, J., Shapiro, H., Shalita-Chesner, M., Lev, S., Grozovski, E., Theilla, M., Frishman, S., & Madar, Z. (2011) · Intensive Care Medicine · doi:10.1007/s00134-011-2146-z · Cited by 566
Total Parenteral Nutrition in the Critically Ill Patient
Heyland, D. K., MacDonald, S., Keefe, L., & Drover, J. (1998) · JAMA · doi:10.1001/jama.280.23.2013 · Cited by 532
Caloric Intake in Medical ICU Patients
Krishnan, J. A., Parce, P., Martinez, A. D., Diette, G. B., & Brower, R. G. (2003) · CHEST Journal · doi:10.1378/chest.124.1.297 · Cited by 439
Simpson, F. O., & Doig, G. S. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2511-2 · Cited by 435
Martindale, R. G., McClave, S. A., Vanek, V. W., McCarthy, M. S., Roberts, P. R., Taylor, B. E., Ochoa, J. B., Napolitano, L. M., & Cresci, G. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181a40116 · Cited by 432
Computerized energy balance and complications in critically ill patients: An observational study
DVIR, D., COHEN, J., & SINGER, P. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2005.10.010 · Cited by 429
Martin, C. M., Doig, G. S., Heyland, D. K., Morrison, T., & Sibbald, W. J. (2004) · PubMed Central · Cited by 380
Early versus late enteral feeding of mechanically ventilated patients: Results of a clinical trial.
Ibrahim, E., Mehringer, L., Prentice, D., Sherman, G., Schaiff, R., Fraser, V, & Kollef, M. (2002) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607102026003174 · Cited by 341
Competing risks as a multi-state model
Andersen, P. K., Abildstrom, S. Z., & Rosthøj, S. (2002) · Statistical Methods in Medical Research · doi:10.1191/0962280202sm281ra · Cited by 321
Sandström, R., Drott, C., Hyltander, A. G., Arfvidsson, B., Scherstén, T., Wickström, I., & Lundholm, K. (1993) · Annals of Surgery · doi:10.1097/00000658-199302000-00013 · Cited by 307
Scheinkestel, C. D., Kar, L., Marshall, K., Bailey, M., Davies, A., Nyulasi, I., & Tuxen, D. V. (2003) · Nutrition · doi:10.1016/s0899-9007(03)00175-8 · Cited by 249
McCowen, K. C., Friel, C. M., Sternberg, J. A., Chan, S., Forse, R. A., Burke, P., & Bistrian, B. R. (2000) · Critical Care Medicine · doi:10.1097/00003246-200011000-00007 · Cited by 242
Insufficient Activation of Autophagy Allows Cellular Damage to Accumulate in Critically Ill Patients
Vanhorebeek, I., Gunst, J., Derde, S., Derese, I., Boussemaere, M., Güiza, F., Martinet, W., Timmermans, J.-P., D'Hoore, A., Wouters, P. J., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2563 · Cited by 241
Self-citationEnteral versus parenteral nutrition: a pragmatic study
Woodcock, N. P., Zeigler, D., Palmer, M., Buckley, P. M., Mitchell, C. J., & MacFie, J. (2001) · Nutrition · doi:10.1016/s0899-9007(00)00576-1 · Cited by 229
Studies in the Basal State and the Response to Total Parenteral Nutrition
SHAW, J. H. F., & Wolfe, R. R. (1989) · Annals of Surgery · doi:10.1097/00000658-198901000-00010 · Cited by 219
Derde, S., Vanhorebeek, I., Güiza, F., Derese, I., Gunst, J., Fahrenkrog, B., Martinet, W., Vervenne, H. B. V. K., Ververs, E.-J., Larsson, L., et al. (2012) · Endocrinology · doi:10.1210/en.2011-2068 · Cited by 169
Dhaliwal, R., Jurewitsch, B., Harrietha, D., & Heyland, D. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2345-y · Cited by 154
Supplementation in Acute Lung Injury—Reply
Rice, T. W., Wheeler, A. P., & Thompson, B. (2012) · JAMA · doi:10.1001/jama.2011.1985 · Cited by 130
Scheinkestel, C. D., Adams, F., Mahony, L., Bailey, M., Davies, A. R., Nyulasi, I. B., & Tuxen, D. V. (2003) · Nutrition · doi:10.1016/s0899-9007(03)00107-2 · Cited by 118
Casaer, M. P., Hermans, G., Wilmer, A. P., & den Berghe, G. V. (2011) · Trials · doi:10.1186/1745-6215-12-21 · Cited by 95
Self-citationMcClave, S. A., Martindale, R. G., Vanek, V. W., McCarthy, M. S., Roberts, P. R., & Taylor, B. E. (2009) · Cited by 81
Parenteral nutrition in septic patients: effect of increasing nitrogen intake
Greig, P. D., Elwyn, D. H., ASKANAZI, J., & Kinney, J. M. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/46.6.1040 · Cited by 79
When Early Enteral Feeding Is Not Possible in Critically Ill Patients
Cahill, N. E., Murch, L., Jeejeebhoy, K. N., McClave, S. A., Day, A. G., Wang, M., & Heyland, D. K. (2011) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607110381405 · Cited by 76
Singer, P. (2007) · Wiener klinische Wochenschrift · doi:10.1007/s00508-007-0794-3 · Cited by 73
Early versus late parenteral nutrition in ICU patients: cost analysis of the EPaNIC trial
Vanderheyden, S., Casaer, M., Kesteloot, K., Simoens, S., Rijdt, T. D., Peers, G., Wouters, P., Coenegrachts, J., Grieten, T., Polders, K., et al. (2012) · Critical Care · doi:10.1186/cc11361 · Cited by 71
Self-citationPredictors of Total Parenteral Nutrition-Induced Lipogenesis
Guenst, J. M., & Nelson, L. D. (1994) · CHEST Journal · doi:10.1378/chest.105.2.553 · Cited by 68
Ridley, E. J., & Davies, A. R. (2011) · Nutrition · doi:10.1016/j.nut.2010.10.010 · Cited by 51
Influence of parenteral nutrition on rates of net substrate oxidation in severe trauma patients
Jeevanandam, M., YOUNG, D. H., & Schiller, W. R. (1990) · Critical Care Medicine · doi:10.1097/00003246-199005000-00001 · Cited by 31
Heidegger, C. P., Graf, S., Thibault, R., Darmon, P., Berger, M., & Pichard, C. (2011) · Clinical Nutrition Supplements · doi:10.1016/s1744-1161(11)70006-0 · Cited by 21
Evidence-based nutrition support in the intensive care unit: an update on reported trial quality
Doig, G. S., Simpson, F. O., & Sweetman, E. A. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32832182b0 · Cited by 20
Early or Late Parenteral Nutrition in Critically Ill Adults
Felbinger, T. W., Weigand, M. A., & Mayer, K. (2011) · New England Journal of Medicine · doi:10.1056/nejmc1110994 · Cited by 16
A comparison of mixed and glucose systems in the total parenteral nutrition of malnourished patients
Iapichino, G. (1987) · Clinical Nutrition · doi:10.1016/0261-5614(87)90060-4 · Cited by 7
Late initiation of parenteral nutrition reduced length of intensive care unit stay
Heyland, D. K. (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-155-10-201111150-02011 · Cited by 3
Doig, G. S. (2008) · JAMA · doi:10.1001/jama.2008.826 · Cited by 1
Research works printed but not linked: 2
- Felbinger, 2011, Early or late parenteral nutrition in critically ill adults [letter], N Engl J Med, 365, 1839, 10.1056/NEJMc1110994 · DOI
- Bistrian, 2011, Early or late parenteral nutrition in critically ill adults, N Engl J Med, 365, 1840
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Self-citationVanhorebeek, I., Latronico, N., & den Berghe, G. V. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05944-4 · Cited by 840
Trial of the Route of Early Nutritional Support in Critically Ill Adults
Harvey, S. E., Parrott, F., Harrison, D. A., Bear, D. E., Segaran, E., Beale, R., Bellingan, G., Leonard, R., Mythen, M. G., & Rowan, K. M. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409860 · Cited by 618
Post‐intensive care syndrome: its pathophysiology, prevention, and future directions
Inoue, S., Hatakeyama, J., Kondo, Y., Hifumi, T., Sakuramoto, H., Kawasaki, T., Taito, S., Nakamura, K., Unoki, T., Kawai, Y., et al. (2019) · Acute Medicine & Surgery · doi:10.1002/ams2.415 · Cited by 653
Metabolic and nutritional support of critically ill patients: consensus and controversies
Preiser, J.-C., van Zanten, A. R., Berger, M. M., Biolo, G., Casaer, M. P., Doig, G. S., Griffiths, R. D., Heyland, D. K., Hiesmayr, M., Iapichino, G., et al. (2015) · Critical Care · doi:10.1186/s13054-015-0737-8 · Cited by 416
Self-citation
Metadata
- Authors
- Casaer, M. P., Wilmer, A., Hermans, G., Wouters, P. J., Mesotten, D., & Van den Berghe, G.
- Affiliations
- Universitair Ziekenhuis Leuven (BE)
- KU Leuven (BE)
- Laboratory and Department of Intensive Care Medicine and
- Corresponding author
- Casaer, Michael P.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-02-01
- Volume
- 187
- Issue
- 3
- Pages
- 247-255
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1840057839
- Semantic Scholar
- 37a3fd62d1564a467a4fe20b913801329a33e0e8
- Cited by
- 307
- References
- 46
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 26 · 2023: 22 · 2022: 24 · 2021: 28 · 2020: 18 · 2019: 23 · 2018: 33 · 2017: 27 · 2016: 12 · 2015: 27 · 2014: 23 · 2013: 9
- FWCI
- 17.54
- Type
- journal article
- Language
- en
- Open access
- green
- lirias.kuleuven.be
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Funders
- European Commission
- Vlaamse regering
- FP7 Ideas: European Research Council (321670)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- early parenteral nutrition, critical illness, glucose supplementation, enteral nutrition, intensive care unit discharge, infection acquisition, disease severity
- MeSH terms
- Aged, Belgium, Energy Intake, Critical Care, Cross Infection, Dietary Carbohydrates, Dietary Proteins, Enteral Nutrition, Female, Humans, Intensive Care Units, Length of Stay, Lipids, Male, Middle Aged, Parenteral Nutrition, Severity of Illness Index, Time Factors, Cohort Studies, Causality, Odds Ratio, Critical Illness, Dietary Supplements, Kaplan-Meier Estimate
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