The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Global Epidemiology of Pediatric Severe Sepsis: The Sepsis Prevalence, Outcomes, and Therapies Study
Open accessAbstract
RATIONALE: Limited data exist about the international burden of severe sepsis in critically ill children. OBJECTIVES: To characterize the global prevalence, therapies, and outcomes of severe sepsis in pediatric intensive care units to better inform interventional trials. METHODS: A point prevalence study was conducted on 5 days throughout 2013-2014 at 128 sites in 26 countries. Patients younger than 18 years of age with severe sepsis as defined by consensus criteria were included. Outcomes were severe sepsis point prevalence, therapies used, new or progressive multiorgan dysfunction, ventilator- and vasoactive-free days at Day 28, functional status, and mortality. MEASUREMENTS AND MAIN RESULTS: Of 6,925 patients screened, 569 had severe sepsis (prevalence, 8.2%; 95% confidence interval, 7.6-8.9%). The patients' median age was 3.0 (interquartile range [IQR], 0.7-11.0) years. The most frequent sites of infection were respiratory (40%) and bloodstream (19%). Common therapies included mechanical ventilation (74% of patients), vasoactive infusions (55%), and corticosteroids (45%). Hospital mortality was 25% and did not differ by age or between developed and resource-limited countries. Median ventilator-free days were 16 (IQR, 0-25), and vasoactive-free days were 23 (IQR, 12-28). Sixty-seven percent of patients had multiorgan dysfunction at sepsis recognition, with 30% subsequently developing new or progressive multiorgan dysfunction. Among survivors, 17% developed at least moderate disability. Sample sizes needed to detect a 5-10% absolute risk reduction in outcomes within interventional trials are estimated between 165 and 1,471 [corrected] patients per group. CONCLUSIONS: Pediatric severe sepsis remains a burdensome public health problem, with prevalence, morbidity, and mortality rates similar to those reported in critically ill adult populations. International clinical trials targeting children with severe sepsis are warranted.
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International Study of the Prevalence and Outcomes of Infection in Intensive Care Units
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Hematological Problems in Pediatric Intensive Care
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Sepsis in European intensive care units: Results of the SOAP study*
Vincent, J.-L., Sakr, Y., Sprung, C. L., Ranieri, V. M., Reinhart, K., Gerlach, H., Moreno, R., Carlet, J., Le Gall, J.-R., & Payen, D. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000194725.48928.3a · Cited by 2,836
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Mortality after Fluid Bolus in African Children with Severe Infection
Maitland, K., Kiguli, S., Opoka, R. O., Engoru, C., Olupot-Olupot, P., Akech, S. O., Nyeko, R., Mtove, G., Reyburn, H., Lang, T., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1101549 · Cited by 1,592
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Sepsis: pathophysiology and clinical management
Gotts, J. E., & Matthay, M. A. (2016) · BMJ · doi:10.1136/bmj.i1585 · Cited by 1,243
European Resuscitation Council Guidelines 2021: Paediatric Life Support
Van de Voorde, P., Turner, N. M., Djakow, J., de Lucas, N., Martinez-Mejias, A., Biarent, D., Bingham, R., Brissaud, O., Hoffmann, F., Johannesdottir, G. B., et al. (2021) · Resuscitation · doi:10.1016/j.resuscitation.2021.02.015 · Cited by 448
The global burden of sepsis: barriers and potential solutions
Rudd, K. E., Kissoon, N., Limmathurotsakul, D., Bory, S., Mutahunga, B., Seymour, C. W., Angus, D. C., & West, T. E. (2018) · Critical Care · doi:10.1186/s13054-018-2157-z · Cited by 416
Singh, Y., Villaescusa, J. U., da Cruz, E. M., Tibby, S. M., Bottari, G., Saxena, R., Guillén, M., Herce, J. L., Di Nardo, M., Cecchetti, C., et al. (2020) · Critical Care · doi:10.1186/s13054-020-03326-2 · Cited by 86
Han, Y. J., Kim, S., Shin, H., Kim, H. W., & Park, J. D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1451356 · Cited by 17
Metadata
- Authors
- Weiss, S. L., Fitzgerald, J. C., Pappachan, J., Wheeler, D., Jaramillo-Bustamante, J. C., Salloo, A., Singhi, S. C., Erickson, S., Roy, J. A., Bush, J. L., Nadkarni, V. M., & Thomas, N. J.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-05-15
- Volume
- 191
- Issue
- 10
- Pages
- 1147-1157
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2052233685
- Cited by
- 1,043
- References
- 47
- FWCI
- 46.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Weiss, S. L., Fitzgerald, J. C., Pappachan, J., Wheeler, D., Jaramillo-Bustamante, J. C., Salloo, A., Singhi, S. C., Erickson, S., Roy, J. A., Bush, J. L., Nadkarni, V. M., & Thomas, N. J. (2015). Global Epidemiology of Pediatric Severe Sepsis: The Sepsis Prevalence, Outcomes, and Therapies Study. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201412-2323oc
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