The global burden of sepsis: barriers and potential solutions

Rudd, Kristina E.; Kissoon, Niranjan; Limmathurotsakul, Direk; Bory, Sotharith; Mutahunga, Birungi; Seymour, Christopher W.; Angus, Derek C.; West, T. Eoin

doi:10.1186/s13054-018-2157-z

Cited by 421Sepsis Diagnosis and TreatmentNeonatal and Maternal InfectionsAntibiotic Use and Resistance

The global burden of sepsis: barriers and potential solutions

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Rudd, Kristina E., Kissoon, Niranjan, Limmathurotsakul, Direk, Bory, Sotharith, Mutahunga, Birungi, Seymour, Christopher W., Angus, Derek C., West, T. Eoin·2018·Critical Care

DOI 10.1186/s13054-018-2157-zPMC PMC6151187

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Abstract

Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequity, and under-resourced and low-resilience public health and acute health care delivery systems. Important differences in the populations at risk, infecting pathogens, and clinical capacity to manage sepsis in high and low-resource settings necessitate context-specific approaches to this significant problem. We review these challenges and propose strategies to overcome them. These strategies include strengthening health systems, accurately identifying and quantifying sepsis cases, conducting inclusive research, establishing data-driven and context-specific management guidelines, promoting creative clinical interventions, and advocacy.

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The persistently high AMR mortality rate in sub-Saharan Africa reflects many of the challenges that LMICs broadly face, including fragmented health systems, inadequate ICU facilities, overcrowded ICUs, staff shortages, inadequate universal access to WASH, few trained infection prevention and control personnel, underdeveloped microbiological capacity, and limited access to antibiotics.
“The persistently high AMR mortality rate in this super-region reflects many of the challenges that LMICs broadly face, which include fragmented health systems, inadequate intensive care units (ICU) facilities, overcrowded ICUs, staff shortages, inadequate universal access to WASH, few trained infection prevention and control personnel, underdeveloped microbiological capacity, and limited access to”
From Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050 (2024) · cites this paper as [61]
The sections on critical care capacity, human resources, facilities, and diagnostic capacity describe overcrowded ICUs, staffing shortages, inadequate sanitation, and limited microbiology services in low-resource settings. The antimicrobials section also describes limited access to effective antibiotics in LMICs. But the paper does not establish a persistently high AMR mortality rate in sub-Saharan Africa or attribute that regional rate to these challenges; it also does not specifically document a shortage of trained infection prevention and control personnel. (LLM, conf=0.88)
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Background
Ventilatory support of patients with sepsis or septic shock in resource-limited settings
Neto, A. S., Schultz, M. J., & Festić, E. (2015) · Intensive Care Medicine · doi:10.1007/s00134-015-4070-0 · Cited by 34 · see citing works
Identifying resource needs for sepsis care and guideline implementation in the Democratic Republic of the Congo: a cluster survey of 66 hospitals in four eastern provinces.
Baelani, I., Jochberger, S., Laimer, T., Rex, C. S., Baker, T., Wilson, I. H., Grander, W., & Dünser, M. W. (2012) · PubMed · Cited by 33 · see citing works
Point-of-care and point-of-‘can’: leveraging reference-laboratory capacity for integrated diagnosis of fever syndromes in the tropics
Semret, M., Ndao, M., Jacobs, J. A., & Yansouni, C. P. (2018) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2018.03.044 · Cited by 33 · see citing works
Is it still worthwhile to perform quarterly cd4+ t lymphocyte cell counts on hiv-1 infected stable patients?
Biagio, A. D., Ameri, M., Sirello, D., Cenderello, G., di Bella, E., Taramasso, L., Giannini, B., Giacomini, M. L., Viscoli, C., Cassola, G., et al. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-017-2199-x · Cited by 29 · see citing works
Perceptions and Attitudes of Egyptian Health Professionals and Policy-Makers towards Pharmaceutical Sales Representatives and Other Promotional Activities
Kamal, S., Holmberg, C., Russell, J., Bochenek, T., Tobiasz‐Adamczyk, B., Fischer, C., & Tinnemann, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140457 · Cited by 27 · see citing works
Risk Factors for Invasive Pneumococcal Disease Among Children Less Than 5 Years of Age in a High HIV Prevalence Setting, South Africa, 2010 to 2012
von Mollendorf, C., Cohen, C., de Gouveia, L., Naidoo, N., Meiring, S. T., Quan, V., Lindani, S., Moore, D. P., Reubenson, G., Moshe, M., et al. (2014) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000000484 · Cited by 21 · see citing works
The molecular epidemiology of Salmonella Typhi across Indonesia reveals bacterial migration
Moehario, L. H. (2009) · The Journal of Infection in Developing Countries · doi:10.3855/jidc.548 · Cited by 20 · see citing works
Epidemiology and Microbiology of Sepsis Syndromes in a University-Affiliated Urban Teaching Hospital and Level-1 Trauma and Burn Center
Tulloch-Palomino, L. G., Chan, J. D., Carlbom, D., Kelly, M. J., Dellit, T. H., & Lynch, J. B. (2015) · Journal of Intensive Care Medicine · doi:10.1177/0885066615592851 · Cited by 19 · see citing works
Rate and pattern of antibiotic resistance in microbiological cultures of sepsis patients in a low-middle-income country's ICU.
Bataar, O., Khuderchuluun, C., Lundeg, G., Chimeddorj, S., Brunauer, A., Gradwohl-Matis, I., & Dünser, M. W. (2013) · PubMed · Cited by 18 · see citing works
Trends in antimicrobial susceptibility of Gram-negative bacteria isolated from blood in Jakarta from 2002 to 2008
Moehario, L. H., Tjoa, E., Kiranasari, A., Ningsih, I., Rosana, Y., & Karuniawati, A. (2009) · The Journal of Infection in Developing Countries · doi:10.3855/jidc.85 · Cited by 17 · see citing works
Preventing Intensive Care Admissions for Sepsis in Tropical Africa (PICASTA)
Pollach, G., & Namboya, F. (2013) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e318291774b · Cited by 15 · see citing works
Influence of drug promotion on prescribing habits of doctors in a teaching hospital.
Akande, T. M., & Aderibigbe, S. A. (2007) · PubMed · Cited by 15 · see citing works
Building Laboratory Capacity to Strengthen Health Systems
Orozco, J. D., Greenberg, L., Desai, I. K., Anglade, F., Ruhangaza, D., Johnson, M., Ivers, L. C., Milner, D. A., & Farmer, P. E. (2017) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2017.10.008 · Cited by 15 · see citing works
Projections for Achieving the Lancet Commission Recommended Surgical Rate of 5000 Operations per 100,000 Population by Region‐Specific Surgical Rate Estimates
Uribe‐Leitz, T., Esquivel, M. M., Molina, G., Lipsitz, S. R., Verguet, S., Rose, J., Bickler, S. W., Gawande, A. A., Haynes, A. B., & Weiser, T. G. (2015) · World Journal of Surgery · doi:10.1007/s00268-015-3113-6 · Cited by 12 · see citing works
Plasmodium falciparum malaria cases detected for prompt treatment by rapid diagnostic tests in the Ho Teaching Hospital of the Volta Region of Ghana
Dinko, B., Amakpa, E. Y., Kweku, M. A., Amoah, P., Tampuori, J., Adjuik, M., Awandare, G. A., & Deitsch, K. (2018) · Parasite Epidemiology and Control · doi:10.1016/j.parepi.2018.e00072 · Cited by 12 · see citing works
Treatment of Severe Sepsis with Artemether-Lumefantrine Is Associated with Decreased Mortality in Ugandan Patients without Malaria
Moore, C. C., Jacob, S. T., Pinkerton, R., Banura, P., Meya, D. B., Reynolds, S. J., Kenya‐Mugisha, N., Mayanja‐Kizza, H., & _, _. (2009) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2009.80.723 · Cited by 11 · see citing works
Who Should Get Pediatric Intensive Care When Not All Can? A Call for International Guidelines on Allocation of Pediatric Intensive Care Resources*
Kissoon, N. “., & Burns, J. P. (2014) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000000038 · Cited by 10 · see citing works
Self-citation
Venous thromboembolism prophylaxis with anticoagulation in septic patients: a prospective cohort study
Zusman, O., Paul, M., Farbman, L., Daitch, V., Akayzen, Y., Witberg, G., Avni, T., Gafter‐Gvili, A., & Leibovici, L. (2014) · QJM · doi:10.1093/qjmed/hcu183 · Cited by 9 · see citing works
Building Cross-Country Networks for Laboratory Capacity and Improvement
Schneidman, M., Matu, M., Nkengasong, J. N., Githui, W., Kalyesubula, S., & Silva, K. A. (2018) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2017.10.009 · Cited by 8 · see citing works
Sepsis – Kenntnisstand des nichtärztlichen Personals in Afrika
Peltola, L., Goddia, C., Namboya, F., Brunkhorst, F. M., & Pollach, G. (2013) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-013-0215-5 · Cited by 7 · see citing works

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[49]Review on Antimicrobial Resistance Antimicrobial resistance: tackling a crisis for the health and wealth of nations 2014

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Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050
Naghavi, M., Vollset, S. E., Ikuta, K. S., Swetschinski, L. R., Gray, A. P., Wool, E. E., Robles Aguilar, G., Mestrovic, T., Smith, G., Han, C., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01867-1 · Cited by 3,791 · see citing works
Incidence and mortality of hospital- and ICU-treated sepsis: Results from an updated and expanded systematic review and meta-analysis.
Fleischmann-Struzek, C., Mellhammar, L., Rose, N., Cassini, A., Rudd, K. E., Schlattmann, P., Allegranzi, B., & Reinhart, K. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06151-x · Cited by 982 · see citing works
Self-citation
Prevalence and outcomes of infection among patients in intensive care units in 2017.
Vincent, J.-L., Sakr, Y., Singer, M., Martin-Loeches, I., Machado, F. R., Marshall, J. C., Finfer, S., Pelosi, P., Brazzi, L., Aditianingsih, D., et al. (2020) · JAMA · doi:10.1001/jama.2020.2717 · Cited by 1,011 · see citing works
Self-citation
An immune-cell signature of bacterial sepsis
Reyes, M., Filbin, M. R., Bhattacharyya, R. P., Billman, K., Eisenhaure, T., Hung, D. T., Levy, B. D., Baron, R. M., Blainey, P. C., Goldberg, M. B., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0752-4 · Cited by 493 · see citing works
The Global Burden of Sepsis and Septic Shock
Via, L. L., Sangiorgio, G., Stefani, S., Marıno, A., Nunnari, G., Cocuzza, S. G., Mantia, I. L., Cacopardo, B. S., Stracquadanio, S., Spampinato, S., et al. (2024) · Epidemiologia · doi:10.3390/epidemiologia5030032 · Cited by 289 · see citing works
Organ Dysfunction in Sepsis: An Ominous Trajectory From Infection To Death.
Caraballo, C., & Jaimes, F. A. (2019) · Europe PMC (PubMed Central) · Cited by 244 · see citing works
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
Vanderbeke, L., Van Mol, P., Van Herck, Y., De Smet, F., Humblet-Baron, S., Martinod, K., Antoranz, A., Arijs, I., Boeckx, B., Bosisio, F. M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24360-w · Cited by 247 · see citing works
Neonatal sepsis and mortality in low-income and middle-income countries from a facility-based birth cohort: an international multisite prospective observational study
Milton, R., Gillespie, D., Dyer, C., Taiyari, K., Carvalho, M. J., Thomson, K., Sands, K. M., Portal, E. A. R., Hood, K., Ferreira, A., et al. (2022) · The Lancet Global Health · doi:10.1016/s2214-109x(22)00043-2 · Cited by 257 · see citing works
Sepsis: key insights, future directions, and immediate goals. A review and expert opinion
Martín‐Loeches, I., Singer, M., & Léone, M. (2024) · Intensive Care Medicine · doi:10.1007/s00134-024-07694-z · Cited by 190 · see citing works
Multidrug-Resistant Sepsis: A Critical Healthcare Challenge
Kumar, N. R., Balraj, T. A., Kempegowda, S. N., & Prashant, A. (2024) · Antibiotics · doi:10.3390/antibiotics13010046 · Cited by 178 · see citing works
Stress related disorders and subsequent risk of life threatening infections: population based sibling controlled cohort study
Song, H., Fall, K., Fang, F., Erlendsdóttir, H., Lu, D., Mataix‐Cols, D., de la Cruz, L. F., D'Onofrio, B. M., Lichtenstein, P., Gottfreðsson, M., et al. (2019) · BMJ · doi:10.1136/bmj.l5784 · Cited by 97 · see citing works
Sepsis and Septic Shock
Acevedo, R. H. (2017) · The American Pharmacists Association eBooks · doi:10.21019/pharmacotherapyfirst.septic-shock_overview · Cited by 86 · see citing works
Characteristics and one year outcomes of melioidosis patients in Northeastern Thailand: a prospective, multicenter cohort study
Chantratita, N., Phunpang, R., Yarasai, A., Dulsuk, A., Yimthin, T., Onofrey, L. A., Coston, T. D., Thiansukhon, E., Chaisuksant, S., Tanwisaid, K., et al. (2022) · The Lancet Regional Health - Southeast Asia · doi:10.1016/j.lansea.2022.100118 · Cited by 75 · see citing works
Self-citation
Protective Features of Autophagy in Pulmonary Infection and Inflammatory Diseases
Wang, K., Chen, Y., Zhang, P., Lin, P., Xie, N., & Wu, M. (2019) · Cells · doi:10.3390/cells8020123 · Cited by 72 · see citing works
Sepsis Among Medicare Beneficiaries: 3. The Methods, Models, and Forecasts of Sepsis, 2012–2018*
Buchman, T. G., Simpson, S. Q., Sciarretta, K. L., Finne, K. P., Sowers, N., Collier, M. W., Chavan, S., Oke, I., Pennini, M. E., Santhosh, A., et al. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004225 · Cited by 65 · see citing works
Global, regional, and national burden of neonatal sepsis and other neonatal infections, 1990–2019: findings from the Global Burden of Disease Study 2019
Li, J., Xiang, L., Chen, X., Li, S., Sun, Q., Cheng, X., & Hua, Z. (2023) · European Journal of Pediatrics · doi:10.1007/s00431-023-04911-7 · Cited by 62 · see citing works
Sepsis hospitalization and risk of subsequent cardiovascular events in adults: a population-based matched cohort study
Angriman, F., Rosella, L. C., Lawler, P. R., Ko, D. T., Wunsch, H., & Scales, D. C. (2022) · Intensive Care Medicine · doi:10.1007/s00134-022-06634-z · Cited by 60 · see citing works
Blood transcriptome analysis of patients with uncomplicated bacterial infection and sepsis
Herwanto, V., Tang, B. M. P., Wang, Y., Shojaei, M., Nalos, M., Shetty, A., Lai, K., McLean, A. S., & Schughart, K. (2021) · BMC Research Notes · doi:10.1186/s13104-021-05488-w · Cited by 59 · see citing works
The Association Between Neighborhood Socioeconomic Disadvantage and Readmissions for Patients Hospitalized With Sepsis
Galiatsatos, P., Follin, A., Alghanim, F., Sherry, M., Sylvester, C., Daniel, Y., Chanmugam, A. S., Townsend, J., Saria, S., Kind, A., et al. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004307 · Cited by 55 · see citing works
Challenges and Solutions in translating sepsis guidelines into practice in resource-limited settings
Ranjit, S., & Kissoon, N. “. (2021) · Translational Pediatrics · doi:10.21037/tp-20-310 · Cited by 61 · see citing works
Self-citation
Optimizing artificial intelligence in sepsis management: Opportunities in the present and looking closely to the future
O'Reilly, D., McGrath, J., & Martin-Loeches, I. (2024) · Journal of Intensive Medicine · doi:10.1016/j.jointm.2023.10.001 · Cited by 55 · see citing works
The Surviving Sepsis Campaign: research priorities for the administration, epidemiology, scoring and identification of sepsis
Nunnally, M., Ferrer, R., Martin, G. S., Martín‐Loeches, I., Machado, F. R., Backer, D. D., Coopersmith, C. M., Deutschman, C. S., Antonelli, M. M., Hellman, J., et al. (2021) · Intensive Care Medicine Experimental · doi:10.1186/s40635-021-00400-z · Cited by 56 · see citing works
Enhanced bedside mortality prediction combining point-of-care lactate and the quick Sequential Organ Failure Assessment (qSOFA) score in patients hospitalised with suspected infection in southeast Asia: a cohort study
Wright, S. W., Hantrakun, V., Rudd, K. E., Lau, C., Lie, K. C., Chau, N. V. V., Teparrukkul, P., West, T. E., & Limmathurotsakul, D. (2022) · The Lancet Global Health · doi:10.1016/s2214-109x(22)00277-7 · Cited by 50 · see citing works
Self-citation
Antimicrobial resistance in Salmonella: One Health perspective on global food safety challenges
Kumar, R., Adeyemi, N. O., Chattaraj, S., Alloun, W., Thamarsha, A. K. A. N. W. M. R. K., Andjelković, S., Mitra, D., & Gautam, P. (2025) · Science in One Health · doi:10.1016/j.soh.2025.100117 · Cited by 50 · see citing works
Hypoxia‐inducible factors in metabolic reprogramming during sepsis
Vanderhaeghen, T., Vandewalle, J., & Libert, C. (2020) · FEBS Journal · doi:10.1111/febs.15222 · Cited by 47 · see citing works
Integrative single-cell RNA sequencing and metabolomics decipher the imbalanced lipid-metabolism in maladaptive immune responses during sepsis
She, H., Tan, L., Wang, Y., Du, Y., Zhou, Y., Zhang, J., Du, Y., Guo, N., Wu, Z., Li, Q., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1181697 · Cited by 48 · see citing works
Haemodynamic support for paediatric septic shock: a global perspective
Ranjit, S., Kissoon, N. “., Argent, A. C., Inwald, D. P., Ventura, A. M. C., Jaborinsky, R., Sankar, J., de Souza, D. C., Natraj, R., de Oliveira, C. F., et al. (2023) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(23)00103-7 · Cited by 48 · see citing works
Self-citation
Ventilator Bundles in Transition: From Prevention of Ventilator-Associated Pneumonia to Prevention of Ventilator-Associated Events
Kallet, R. H. (2019) · Respiratory Care · doi:10.4187/respcare.06966 · Cited by 48 · see citing works
Interleukin-17D Aggravates Sepsis by Inhibiting Macrophage Phagocytosis
Yan, X., Tu, H., Liu, Y., Chen, T., & Cao, J. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000004070 · Cited by 47 · see citing works
Defining sepsis in small animals
Cortellini, S., DeClue, A. E., Giunti, M., Goggs, R. A. N., Hopper, K., Menard, J. M., Rabelo, R. C., Rozanski, E. A., Sharp, C. R., Silverstein, D. C., et al. (2024) · Journal of Veterinary Emergency and Critical Care · doi:10.1111/vec.13359 · Cited by 52 · see citing works
Critical care capacity in Haiti: A nationwide cross-sectional survey
Losonczy, L. I., Barnes, S., Liu, S., Williams, S. R., McCurdy, M. T., Lemos, V., Chandler, J., Colas, L. N., Augustin, M. E., & Papali, A. C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218141 · Cited by 46 · see citing works
Circadian rhythms in septic shock patients
Lachmann, G., Ananthasubramaniam, B., Wünsch, V. A., Scherfig, L.-M., von Haefen, C., Knaak, C., Edel, A., Ehlen, L., Koller, B., Goldmann, A., et al. (2021) · Annals of Intensive Care · doi:10.1186/s13613-021-00833-5 · Cited by 44 · see citing works
sTREM-1 predicts mortality in hospitalized patients with infection in a tropical, middle-income country
Wright, S. W., Lovelace-Macon, L., Hantrakun, V., Rudd, K. E., Teparrukkul, P., Harju-Baker, S., Liles, W. C., Limmathurotsakul, D., & West, T. E. (2020) · BMC Medicine · doi:10.1186/s12916-020-01627-5 · Cited by 43 · see citing works
Self-citation
Epidemiology and outcomes of sepsis among hospitalizations with systemic lupus erythematosus admitted to the ICU: a population-based cohort study
Oud, L. (2020) · Journal of Intensive Care · doi:10.1186/s40560-019-0424-y · Cited by 42 · see citing works
Causes of morbidity and mortality among patients admitted in a tertiary hospital in southern Nigeria: A 6 year evaluation
Okoroiwu, H. U., Uchendu, I. K., & Essien, R. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237313 · Cited by 42 · see citing works
Nurses' knowledge and confidence in recognizing and managing patients with sepsis: A multi‐site cross‐sectional study
Chua, W. L., Teh, C. S., Basri, M. A. B. A., Ong, S. T., Phang, N. Q. Q., & Goh, E. L. (2022) · Journal of Advanced Nursing · doi:10.1111/jan.15435 · Cited by 41 · see citing works
A Novel Peptide Antibiotic, Pro10-1D, Designed from Insect Defensin Shows Antibacterial and Anti-Inflammatory Activities in Sepsis Models
Krishnan, M., Choi, J., Jang, A., & Kim, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176216 · Cited by 41 · see citing works
Perioperative supplemental oxygen and NT-proBNP concentrations after major abdominal surgery – A prospective randomized clinical trial
Reiterer, C., Kabon, B., Taschner, A., von Sonnenburg, M. F., Graf, A. C., Adamowitsch, N., Starlinger, P. P., Goschin, J., Fraunschiel, M., & Fleischmann, E. (2021) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2021.110379 · Cited by 37 · see citing works
Global health systems' data science approach for precision diagnosis of sepsis in early life
Iregbu, K. C., Dramowski, A., Milton, R., Nsutebu, E. F., Howie, S. R. C., Chakraborty, M., Lavoie, P. M., Costelloe, C. E., & Ghazal, P. (2021) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(21)00645-9 · Cited by 37 · see citing works
MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal Tubular Epithelial Cells during Sepsis Associated Acute Kidney Injury via AKT/CDK2-FOXO1 Pathway
Lin, Z., Liu, Z., Wang, X., Qiu, C., & Zheng, S. (2019) · BioMed Research International · doi:10.1155/2019/2821731 · Cited by 36 · see citing works
Association of autoimmune diseases with the occurrence and 28-day mortality of sepsis: an observational and Mendelian randomization study
Li, H., Pan, X., Zhang, S., Shen, X., Wan, L., Shang, W., Wen, Z., Huang, S., Chen, L., Zhang, X., et al. (2023) · Critical Care · doi:10.1186/s13054-023-04763-5 · Cited by 36 · see citing works
Determining predictors of sepsis at triage among children under 5 years of age in resource-limited settings: A modified Delphi process
Fung, J. S. T., Akech, S., Kissoon, N. “., Wiens, M. O., English, M., & Ansermino, J. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211274 · Cited by 35 · see citing works
Self-citation
Clinical biomarker profiles reveals gender differences and mortality factors in sepsis
Chang, Z., Lu, J., Zhang, Q., Wu, H., Liang, Z., Pan, X., Li, B., Cheng, Z. J., & Sun, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1413729 · Cited by 34 · see citing works
Hydrogen Sulfide: A Versatile Molecule and Therapeutic Target in Health and Diseases
Shahid, A., & Bhatia, M. (2024) · Biomolecules · doi:10.3390/biom14091145 · Cited by 35 · see citing works
Clinical trial design for unmet clinical needs: a spotlight on sepsis
Vincent, J., & Sakr, Y. L. (2019) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2019.1643235 · Cited by 34 · see citing works
Latin American Consensus on the Management of Sepsis in Children: Sociedad Latinoamericana de Cuidados Intensivos Pediátricos [Latin American Pediatric Intensive Care Society] (SLACIP) Task Force: Executive Summary
Fernández‐Sarmiento, J., de Souza, D. C., Martínez, A. S., Nieto, V., López‐Herce, J., Lanziotti, V. S., Lopez, M. D. P. A., de Carvalho, W. B., de Oliveira, C. F., Jaramillo-Bustamante, J. C., et al. (2021) · Journal of Intensive Care Medicine · doi:10.1177/08850666211054444 · Cited by 34 · see citing works
Early Prediction of Mortality for Septic Patients Visiting Emergency Room Based on Explainable Machine Learning: A Real-World Multicenter Study
Park, S. W., Yeo, N. Y., Kang, S., Ha, T., Kim, T. Y., Lee, D., Kim, D., Choi, S., Kim, M., Lee, D., et al. (2024) · Journal of Korean Medical Science · doi:10.3346/jkms.2024.39.e53 · Cited by 33 · see citing works
NEAT1 aggravates sepsis-induced acute kidney injury by sponging miR-22-3p
Feng, Y., Liu, J., Wu, R., Yang, P., Ye, Z., & Song, F. (2020) · Open Medicine · doi:10.1515/med-2020-0401 · Cited by 33 · see citing works
Association of Empiric Antibiotic Regimen Discordance With 30-Day Mortality in Neonatal and Pediatric Bloodstream Infection—A Global Retrospective Cohort Study
Cook, A., Hsia, Y., Russell, N., Sharland, M., Cheung, K., Grimwood, K., Cross, J., da Cunha, D. C., Magalhães, G. R. D. A. A., Renk, H., et al. (2021) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000002910 · Cited by 33 · see citing works
Metabolomics and machine learning approaches for diagnostic and prognostic biomarkers screening in sepsis
She, H., Du, Y., Du, Y., Tan, L., Shunxin, Y., Luo, X., Li, Q., Xiang, X., Lu, H., Hu, Y., et al. (2023) · BMC Anesthesiology · doi:10.1186/s12871-023-02317-4 · Cited by 32 · see citing works
The burden and costs of sepsis and reimbursement of its treatment in a developing country: An observational study on focal infections in Indonesia
Purba, A. K. R., Mariana, N., Aliska, G., Wijaya, S. H., Wulandari, R. R., Hadi, U., Hamzah, H., Nugroho, C. W., van der Schans, J., & Postma, M. J. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.04.075 · Cited by 31 · see citing works
Norepinephrine in Septic Shock: A Systematic Review and Meta-analysis
bin Ruslan, M. R., Baharuddin, K. A., Norhayati, M. N., Yazid, M., Noh, A. Y. M., & Rahman, A. (2021) · Western Journal of Emergency Medicine · doi:10.5811/westjem.2020.10.47825 · Cited by 35 · see citing works
Nigerian surgical outcomes – Report of a 7-day prospective cohort study and external validation of the African surgical outcomes study surgical risk calculator
Osinaike, B. B., Ayandipo, O. O., Onyeka, T. C., Alagbe-Briggs, O. T., Mohammed, A. D., Oyedepo, O. O., Nuhu, A. M., Asudo, F., Akanmu, O. N., Nwokorie, C., et al. (2019) · International Journal of Surgery · doi:10.1016/j.ijsu.2019.06.003 · Cited by 30 · see citing works
Rapid systematic review on risks and outcomes of sepsis: the influence of risk factors associated with health inequalities
Bladon, S., Ashiru-Oredope, D., Cunningham, N., Pate, A., Martin, G. P., Zhong, X., Gilham, E., Brown, C. S., Mirfenderesky, M., Palin, V., et al. (2024) · International Journal for Equity in Health · doi:10.1186/s12939-024-02114-6 · Cited by 29 · see citing works
Emerging therapeutic targets for sepsis
Tindal, E. W., Armstead, B. E., Monaghan, S. F., Heffernan, D. S., & Ayala, A. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1897107 · Cited by 30 · see citing works
Deep-Learning Model for Screening Sepsis Using Electrocardiography
Kwon, J.-M., Lee, Y. R., Jung, M.-S., Lee, Y.-J., Jo, Y.-Y., Kang, D.-Y., Lee, S. Y., Cho, Y.-H., Shin, J.-H., Ban, J.-H., et al. (2021) · Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine · doi:10.1186/s13049-021-00953-8 · Cited by 28 · see citing works
Responsible Management Education in Time of Crisis: A Conceptual Framework for Public Business Schools in Egypt and Similar Middle Eastern Context
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Authors: Rudd, K. E., Kissoon, N., Limmathurotsakul, D., Bory, S., Mutahunga, B., Seymour, C. W., Angus, D. C., & West, T. E.
Affiliations: University of Pittsburgh (US)
University of British Columbia (CA)
Mahidol University (TH)
Calmette Hospital (KH)
University of Washington (US)
Corresponding author: Rudd, Kristina E.
ORCID: Rudd, Kristina E.
Kissoon, Niranjan
Limmathurotsakul, Direk
Bory, Sotharith
Mutahunga, Birungi
Seymour, Christopher W.
Angus, Derek C.
West, T. Eoin
Venue: Critical Care
Publisher: Springer Science and Business Media LLC
Published: 2018-09-23
Volume: 22
Issue: 1
Pages: 232-232
ISSN: 1364-8535 (ISSN-L)
DOI: 10.1186/s13054-018-2157-z
PMC: PMC6151187
OpenAlex: W2891115123
Cited by: 416
References: 87
Citations by year: 2026: 30 · 2025: 47 · 2024: 102 · 2023: 56 · 2022: 56 · 2021: 54 · 2020: 43 · 2019: 27 · 2017: 1
FWCI: 4.43
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Critical Care (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
cIRcle (University of British Columbia) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Open Collections
Funders: National Heart, Lung, and Blood Institute (T32HL007287)
Topics: Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
Keywords: sepsis, global burden of disease, low- and middle-income countries, sepsis mortality, health disparities, health system resilience, sepsis management guidelines, sepsis research, health advocacy, sepsis awareness
MeSH terms: Developing Countries, Health Resources, Humans, Global Health, Cost of Illness, Sepsis

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