The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Blood Eosinophils and Exacerbations in Chronic Obstructive Pulmonary Disease. The Copenhagen General Population Study
Abstract
RATIONALE: Whether high blood eosinophils are associated with chronic obstructive pulmonary disease (COPD) exacerbations among individuals with COPD in the general population is largely unknown. OBJECTIVES: To test the hypothesis that high blood eosinophils predict COPD exacerbations. METHODS: Among 81,668 individuals in the Copenhagen General Population Study, we examined 7,225 with COPD based on spirometry. We recorded blood eosinophils at baseline and future COPD exacerbations longitudinally, defined as moderate (short-course treatment with systemic corticosteroids) or severe (hospitalization). We also assessed exacerbation risk in a subgroup of 203 individuals with clinical COPD, defined as participants with a smoking history of at least 10 pack-years, FEV1 less than 70% of predicted value, and at least one moderate or severe exacerbation in the year before baseline. MEASUREMENTS AND MAIN RESULTS: During a median of 3.3 years of follow-up (range, 0.03-8.1), 1,439 severe and 2,864 moderate COPD exacerbations were recorded. Among all participants with COPD, blood eosinophils above versus below 0.34 × 10(9) cells per liter had multivariable-adjusted incidence rate ratios of 1.76 (95% confidence interval, 1.56-1.99) for severe exacerbations and 1.15 (1.05-1.27) for moderate exacerbations. Corresponding values in those with clinical COPD were 3.21 (2.49-4.14) and 1.69 (1.40-2.04). In contrast, using a cutpoint of 2% for blood eosinophils, the risk of exacerbations was increased for severe exacerbations only among individuals with clinical COPD and not in individuals in the broader population. CONCLUSIONS: Among individuals with COPD in the general population, increased blood eosinophil levels above 0.34 × 10(9) cells per liter were associated with a 1.76-fold increased risk of severe exacerbations.
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Effect of Exacerbation on Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
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Cited by
Vestbo, J., Papi, A., Corradi, M., Blazhko, V., Montagna, I., Francisco, C., Cohuet, G., Vezzoli, S., Scuri, M., & Singh, D. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30188-5 · Cited by 425
Self-citationWhat is asthma−COPD overlap syndrome? Towards a consensus definition from a round table discussion
Sin, D. D., Miravitlles, M., Mannino, D. M., Soriano, J. B., Price, D., Celli, B. R., Leung, J. M., Nakano, Y., Park, H. Y., Wark, P. A., et al. (2016) · European Respiratory Journal · doi:10.1183/13993003.00436-2016 · Cited by 367
Inflammatory endotypes in COPD
Barnes, P. J. (2019) · Allergy · doi:10.1111/all.13760 · Cited by 313
Singh, D., Bassi, M., Balzano, D., Lucci, G., Emirova, A., Anna Nandeuil, M., Jellema, G., Afolabi, E. K., Leaker, B., Kornmann, O., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16146 · Cited by 20
Metadata
- Authors
- Vedel-Krogh, S., Nielsen, S. F., Lange, P., Vestbo, J., & Nordestgaard, B. G.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-05-01
- Volume
- 193
- Issue
- 9
- Pages
- 965-974
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2192441381
- Cited by
- 431
- References
- 21
- FWCI
- 26.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vedel-Krogh, S., Nielsen, S. F., Lange, P., Vestbo, J., & Nordestgaard, B. G. (2016). Blood Eosinophils and Exacerbations in Chronic Obstructive Pulmonary Disease. The Copenhagen General Population Study. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201509-1869oc
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