The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Mechanisms of Chronic Muscle Wasting and Dysfunction after an Intensive Care Unit Stay. A Pilot Study
Open accessAbstract
RATIONALE: Critical illness survivors often experience permanent functional disability due to intensive care unit (ICU)-acquired weakness. The mechanisms responsible for long-term weakness persistence versus resolution are unknown. OBJECTIVES: To delineate cellular mechanisms underlying long-term weakness persistence in ICU survivors. METHODS: We conducted a nested, prospective study of critically ill patients mechanically ventilated for 7 days or longer. The patients were recruited from the RECOVER program and serially assessed over 6 months after ICU discharge. Twenty-seven of 82 patients consented to participate; 15 and 11 patients were assessed at 7 days and 6 months after ICU discharge, respectively. MEASUREMENTS AND MAIN RESULTS: We assessed motor functional capacity, quadriceps size, strength, and voluntary contractile capacity and performed electromyography, nerve conduction studies, and vastus lateralis biopsies for histologic, cellular, and molecular analyses. Strength and quadriceps cross-sectional areas were decreased 7 days after ICU discharge. Weakness persisted to 6 months and correlated with decreased function. Quadriceps atrophy resolved in 27% patients at 6 months. Muscle mass reconstitution did not correlate with resolution of weakness, owing to persistent impaired voluntary contractile capacity. Compared with Day 7, increased ubiquitin-proteasome system-mediated muscle proteolysis, inflammation, and decreased mitochondrial content all normalized at 6 months. Autophagy markers were normal at 6 months. Patients with sustained atrophy had decreased muscle progenitor (satellite) cell content. CONCLUSIONS: Long-term weakness in ICU survivors results from heterogeneous muscle pathophysiology with variable combinations of muscle atrophy and impaired contractile capacity. These findings are not explained by ongoing muscle proteolysis, inflammation, or diminished mitochondrial content. Sustained muscle atrophy is associated with decreased satellite cell content and compromised muscle regrowth, suggesting impaired regenerative capacity.
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Cites
One-Year Outcomes in Survivors of the Acute Respiratory Distress Syndrome
Herridge, M. S., Cheung, A. M., Tansey, C. M., Matte-Martyn, A., Diaz-Granados, N., Al-Saidi, F., Cooper, A. B., Guest, C. B., Mazer, C. D., Mehta, S., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022450 · Cited by 2,334
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Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration
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Clinical review: intensive care unit acquired weakness
Hermans, G., & Van den Berghe, G. (2015) · Critical Care · doi:10.1186/s13054-015-0993-7 · Cited by 792
Accelerated Loss of Skeletal Muscle Strength in Older Adults With Type 2 Diabetes
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Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome
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Regional changes in muscle mass following 17 weeks of bed rest
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Cited by
One-Year Outcomes in Caregivers of Critically Ill Patients
Cameron, J. I., Chu, L. M., Matte, A., Tomlinson, G., Chan, L., Thomas, C., Friedrich, J. O., Mehta, S., Lamontagne, F., Levasseur, M., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1511160 · Cited by 429
Self-citationMuscular weakness and muscle wasting in the critically ill
Schefold, J. C., Wollersheim, T., Grunow, J. J., Luedi, M. M., Z'Graggen, W. J., & Weber‐Carstens, S. (2020) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12620 · Cited by 193
Out of Control: The Role of the Ubiquitin Proteasome System in Skeletal Muscle during Inflammation
Haberecht-Müller, S., Krüger, E., & Fielitz, J. (2021) · Biomolecules · doi:10.3390/biom11091327 · Cited by 108
Gamrin-Gripenberg, L., Sundström-Rehal, M., Olsson, D., Grip, J., Wernerman, J., & Rooyackers, O. (2018) · Critical Care · doi:10.1186/s13054-017-1932-6 · Cited by 71
Deaccelerated Myogenesis and Autophagy in Genetically Induced Pulmonary Emphysema
Balnis, J., Drake, L. A., Singer, D. V., Vincent, C. E., Korponay, T. C., D’Armiento, J., Lee, C. G., Elias, J. A., Singer, H. A., & Jaitovich, A. (2022) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2021-0351oc · Cited by 27
Metadata
- Authors
- dos Santos, C., Hussain, S. N. A., Mathur, S., Picard, M., Herridge, M., Correa, J., Bain, A., Guo, Y., Advani, A., Advani, S. L., Tomlinson, G., Katzberg, H., Streutker, C. J., Cameron, J. I., Schols, A., Gosker, H. R., & Batt, J.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-10-01
- Volume
- 194
- Issue
- 7
- Pages
- 821-830
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2326471898
- Cited by
- 282
- References
- 12
- FWCI
- 18.67
- Type
- journal article
- Language
- en
- Open access
- green
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- dos Santos, C., Hussain, S. N. A., Mathur, S., Picard, M., Herridge, M., Correa, J., Bain, A., Guo, Y., Advani, A., Advani, S. L., Tomlinson, G., Katzberg, H., Streutker, C. J., Cameron, J. I., Schols, A., Gosker, H. R., & Batt, J. (2016). Mechanisms of Chronic Muscle Wasting and Dysfunction after an Intensive Care Unit Stay. A Pilot Study. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201512-2344oc
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