Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration
Abstract
Distinct cell populations with regenerative capacity have been reported to contribute to myofibres after skeletal muscle injury, including non-satellite cells as well as myogenic satellite cells. However, the relative contribution of these distinct cell types to skeletal muscle repair and homeostasis and the identity of adult muscle stem cells remain unknown. We generated a model for the conditional depletion of satellite cells by expressing a human diphtheria toxin receptor under control of the murine Pax7 locus. Intramuscular injection of diphtheria toxin during muscle homeostasis, or combined with muscle injury caused by myotoxins or exercise, led to a marked loss of muscle tissue and failure to regenerate skeletal muscle. Moreover, the muscle tissue became infiltrated by inflammatory cells and adipocytes. This localised loss of satellite cells was not compensated for endogenously by other cell types, but muscle regeneration was rescued after transplantation of adult Pax7(+) satellite cells alone. These findings indicate that other cell types with regenerative potential depend on the presence of the satellite cell population, and these observations have important implications for myopathic conditions and stem cell-based therapeutic approaches.
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Satellite cells are primarily responsible for driving skeletal muscle repair in response to damaging stimuli such as exercise contraction.
“Muscle stem cells commonly known as satellite cells, are primarily responsible for driving the skeletal muscle repair process to potentially damaging stimuli, such as mechanical stress elicited by exercise contraction.”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [19]
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- Authors
- Sambasivan, R., Yao, R., Kissenpfennig, A., Van Wittenberghe, L., Paldi, A., Gayraud-Morel, B., Guenou, H., Malissen, B., Tajbakhsh, S., & Galy, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Genethon, 1 bis rue de l'Internationale, Evry, F-91002, France.
- ORCID
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2011-09-01
- Volume
- 138
- Issue
- 17
- Pages
- 3647-3656
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2145163771
- Cited by
- 939
- References
- 54
- Citations by year
- 2026: 34 · 2025: 44 · 2024: 57 · 2023: 64 · 2022: 67 · 2021: 75 · 2020: 69 · 2019: 76 · 2018: 76 · 2017: 68 · 2016: 59 · 2015: 89 · 2014: 62 · 2013: 54 · 2012: 37
- FWCI
- 20.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-06-BLAN-0039)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Genetics › Neurogenetic and Muscular Disorders Research
- Keywords
- Pax7, satellite cells, skeletal muscle regeneration, muscle stem cells, diphtheria toxin receptor, muscle damage, myotoxins, exercise-induced muscle damage, muscle homeostasis, cell transplantation, inflammatory cell infiltration, adipocyte infiltration, myogenic cells
- MeSH terms
- Animals, Diphtheria Toxin, Female, Flow Cytometry, Immunohistochemistry, Male, Regeneration, Muscle, Skeletal, Reverse Transcriptase Polymerase Chain Reaction, Satellite Cells, Skeletal Muscle, Mice, PAX7 Transcription Factor
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