The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion
Open accessAbstract
RATIONALE: E-cigarettes have become increasingly popular and little is known about their potential adverse health effects. OBJECTIVES: To determine the effects of e-cigarette use on the airways. METHODS: Induced sputum samples from cigarette smokers, e-cigarette users, and nonsmokers were analyzed by quantitative proteomics, and the total and individual concentrations of mucins MUC5AC and MUC5B were determined by light scattering/refractometry and labeled mass spectrometry, respectively. Neutrophil extracellular trap (NET) formation rates were also determined for the same groups. MEASUREMENTS AND MAIN RESULTS: E-cigarette users exhibited significant increases in aldehyde-detoxification and oxidative stress-related proteins associated with cigarette smoke compared with nonsmokers. The levels of innate defense proteins associated with chronic obstructive pulmonary disease, such as elastase and matrix metalloproteinase-9, were significantly elevated in e-cigarette users as well. E-cigarette users' sputum also uniquely exhibited significant increases in neutrophil granulocyte-related and NET-related proteins, such as myeloperoxidase, azurocidin, and protein-arginine deiminase 4, despite no significant elevation in neutrophil cell counts. Peripheral neutrophils from e-cigarette users showed increased susceptibility to phorbol 12-myristate 13-acetate-induced NETosis. Finally, a compositional change in the gel-forming building blocks of airway mucus (i.e., an elevated concentration of mucin MUC5AC) was observed in both cigarette smokers and e-cigarette users. CONCLUSIONS: Together, our results indicate that e-cigarette use alters the profile of innate defense proteins in airway secretions, inducing similar and unique changes relative to cigarette smoking. These data challenge the concept that e-cigarettes are a healthier alternative to cigarettes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268
Meijer, L., Nelson, D. J., Riazanski, V., Gabdoulkhakova, A. G., Hery-Arnaud, G., Le Berre, R., Loaëc, N., Oumata, N., Galons, H., Nowak, E., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000444256 · Cited by 4,992
Tissue Destruction by Neutrophils
Epstein, F. H., & Weiss, S. J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902093200606 · Cited by 3,950
Tissue Destruction by Neutrophils
(1989) · New England Journal of Medicine · doi:10.1056/nejm198908033210513 · Cited by 3,631
Urban, C. F., Ermert, D., Schmid, M., Abu-Abed, U., Goosmann, C., Nacken, W., Brinkmann, V., Jungblut, P. R., & Zychlinsky, A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000639 · Cited by 1,673
Netting neutrophils in autoimmune small-vessel vasculitis
Kessenbrock, K., Krumbholz, M., Schönermarck, U., Back, W., Gross, W. L., Werb, Z., Gröne, H.-J., Brinkmann, V., & Jenne, D. E. (2009) · Nature Medicine · doi:10.1038/nm.1959 · Cited by 1,648
Tobacco Use Among Middle and High School Students — United States, 2011–2015
Singh, T., Arrazola, R. A., Corey, C. G., Husten, C. G., Neff, L. J., Homa, D. M., & King, B. A. (2016) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6514a1 · Cited by 1,240
Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis
Lin, A. M., Rubin, C. J., Khandpur, R., Wang, J. Y., Riblett, M., Yalavarthi, S., Villanueva, E. C., Shah, P., Kaplan, M. J., & Bruce, A. T. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100123 · Cited by 906
Neutrophil granules: a library of innate immunity proteins
Borregaard, N., Sørensen, O. E., & Theilgaard-Mönch, K. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.06.002 · Cited by 739
Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality
Remijsen, Q., Kuijpers, T. W., Wirawan, E., Lippens, S., Vandenabeele, P., & Vanden Berghe, T. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2011.1 · Cited by 607
Cited by
What are the respiratory effects of e-cigarettes?
Gotts, J. E., Jordt, S.-E., McConnell, R., & Tarran, R. (2019) · BMJ · doi:10.1136/bmj.l5275 · Cited by 516
Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine
Madison, M. C., Landers, C. T., Gu, B.-H., Chang, C.-Y., Tung, H.-Y., You, R., Hong, M. J., Baghaei, N., Song, L.-Z., Porter, P., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128531 · Cited by 391
Role of inflammatory cells in airway remodeling in COPD
Wang, Y., Xu, J., Meng, Y., Adcock, I. M., & Yao, X. (2018) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s176122 · Cited by 373
Association of E-Cigarette Use With Respiratory Disease Among Adults: A Longitudinal Analysis
Bhatta, D. N., & Glantz, S. A. (2020) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2019.07.028 · Cited by 292
Eisenberg, M. J., Hébert-Losier, A., Windle, S. B., Greenspoon, T., Brandys, T., Fülöp, T., Nguyen, T., Elkouri, S., Montigny, M., Wilderman, I., et al. (2020) · JAMA · doi:10.1001/jama.2020.18889 · Cited by 110
Metadata
- Authors
- Reidel, B., Radicioni, G., Clapp, P. W., Ford, A. A., Abdelwahab, S., Rebuli, M. E., Haridass, P., Alexis, N. E., Jaspers, I., & Kesimer, M.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-02-15
- Volume
- 197
- Issue
- 4
- Pages
- 492-501
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2766814588
- Cited by
- 375
- References
- 45
- FWCI
- 23.86
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion. https://app.cochat.ai/papers/10.1164/rccm.201708-1590oc
- The paper
- Reidel, B., Radicioni, G., Clapp, P. W., Ford, A. A., Abdelwahab, S., Rebuli, M. E., Haridass, P., Alexis, N. E., Jaspers, I., & Kesimer, M. (2018). E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201708-1590oc
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
