Loss of microbial topography between oral and nasopharyngeal microbiota and development of respiratory infections early in life.
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Abstract Rationale The respiratory microbiota is increasingly being appreciated as an important mediator in the susceptibility to childhood respiratory tract infections (RTIs). Pathogens are presumed to originate from the nasopharyngeal ecosystem. Objectives To investigate the association between early life respiratory microbiota and development of childhood RTIs. Methods In a prospective birth cohort (Microbiome Utrecht Infant Study: MUIS), we characterized the oral microbiota longitudinally from birth until 6 months of age of 112 infants (nine regular samples/subject) and compared them with nasopharyngeal microbiota using 16S-rRNA–based sequencing. We also characterized oral and nasopharynx samples during RTI episodes in the first half year of life. Measurements and Main Results Oral microbiota were driven mostly by feeding type, followed by age, mode of delivery, and season of sampling. In contrast to our previously published associations between nasopharyngeal microbiota development and susceptibility to RTIs, oral microbiota development was not directly associated with susceptibility to RTI development. However, we did observe an influx of oral taxa, such as Neisseria lactamica, Streptococcus, Prevotella nanceiensis, Fusobacterium, and Janthinobacterium lividum, in the nasopharyngeal microbiota before and during RTIs, which was accompanied by reduced presence and abundance of Corynebacterium, Dolosigranulum, and Moraxella spp. Moreover, this phenomenon was accompanied by reduced niche differentiation indicating loss of ecological topography preceding confirmed RTIs. This loss of ecological topography was further augmented by start of daycare, and linked to consecutive development of symptomatic infections. Conclusions Together, our results link the loss of topography to subsequent development of RTI episodes. This may lead to new insights for prevention of RTIs and antibiotic use in childhood.
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A half-year prospective cohort study showed that nasopharyngeal microecological imbalance was caused by transcolonization of oral microbiota, leading to upper respiratory tract infections.
“A half-year prospective cohort study (Man et al., 2019) showed that nasopharyngeal microecological imbalance was caused by transcolonization of oral microbiota, leading to upper respiratory tract infections.”
From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Man et al., 2019
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- Authors
- Man, W. H., Clerc, M., de Steenhuijsen Piters, W. A. A., van Houten, M. A., Chu, M. L. J. N., Kool, J., Keijser, B. J. F., Sanders, E. A. M., & Bogaert, D.
- Affiliations
- Netherlands Organisation for Applied Scientific Research (NL)
- Medical Research Council, Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
- Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children’s Hospital, and
- Spaarne Gasthuis Academy, Hoofddorp and Haarlem, the Netherlands
- University Medical Center Utrecht (NL)
- Corresponding author
- Bogaert, Debby
- ORCID
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-09
- Volume
- 200
- Issue
- 6
- Pages
- 760-770
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2921698511
- Cited by
- 89
- References
- 26
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 12 · 2023: 14 · 2022: 11 · 2021: 14 · 2020: 19 · 2019: 5
- FWCI
- 14.21
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.library.uu.nl
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- The Netherlands Organization for Scientific Research (NWO-VIDI; grant 91715359)
- Wilhelmina Children’s Hospital and Spaarne Gasthuis Hoofddorp intramural funds
- Chief Scientist Office/NHS Research Scotland Scottish Senior Clinical Fellowship award
- University of Edinburgh, and Top Consortia for Knowledge and Innovation (TKI-AF-12190)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Health Professions › Emergency Medical Services › Pediatric health and respiratory diseases
- Keywords
- oral microbiota, nasopharyngeal microbiota, respiratory infections, pediatric respiratory infection, niche differentiation, daycare attendance, feeding type, Neisseria lactamica, Streptococcus, Prevotella nanceiensis, Fusobacterium, Janthinobacterium lividum, Corynebacterium, Moraxella, Dolosigranulum, infection susceptibility
- MeSH terms
- Female, Humans, Infant, Infant, Newborn, Longitudinal Studies, Male, Mouth, Nasopharynx, Prospective Studies, Respiratory Tract Infections, Microbiota
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