Respiratory commensal bacteria corynebacterium pseudodiphtheriticum improves resistance of infant mice to respiratory syncytial virus and streptococcus pneumoniae superinfection
Open accessAbstract
Corynebacterium pseudodiphtheriticum is a Gram-positive bacterium found as a member of the normal microbiota of the upper respiratory tract. It was suggested that C. pseudodiphtheriticum may be potentially used as a next-generation probiotic for nasal application, although no deep studies were performed in this regard. We hypothesized that human isolate C. pseudodiphtheriticum strain 090104 is able to modulate the respiratory innate immune response and beneficially influence the resistance to viral and bacterial infections. Therefore, in the present study we investigated how the exposure of infant mice to nasal priming with viable or non-viable C. pseudodiphtheriticum 090104 influences the respiratory innate immune response triggered by Toll-like receptor (TLR)-3 activation, the susceptibility to primary Respiratory Synsytial Virus (RSV) infection, and the resistance to secondary Streptococcus pneumoniae pneumonia. We demonstrated that the nasal priming with viable C. pseudodiphtheriticum 090104 differentially modulated TLR3-mediated innate antiviral immune response in the respiratory tract of infant mice, improving their resistance to primary RSV infection, and secondary pneumococcal pneumonia. In association with the protection against RSV-pneumococcal superinfection, we found that viable C. pseudodiphtheriticum improved lung CD3+CD4+IFN-γ+, and CD3+CD4+IL-10+ T cells as well as CD11c+SiglecF+IFN-β+ alveolar macrophages. Of interest, non-viable bacteria did not have the same protective effect, suggesting that C. pseudodiphtheriticum colonization is needed for achieving its protective effect. In conclusion, we present evidence that nasal application of viable C. pseudodiphtheriticum could be thought as an alternative to boost defenses against RSV and secondary pneumococcal pneumonia, which should be further studied and validated in clinical trials. Due to the absence of a long-lasting immunity, re-infection with RSV throughout life is common. Thus, a possible perspective use could be a seasonal application of a nasal probiotic spray to boost respiratory innate immunity in immunocompetent subjects.
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A recent preclinical study using a murine model of RSV and S. pneumoniae superinfection employed nasal priming by a C. pseudodiphtheriticum strain to augment host defense against the viral infection, which enhanced clearance of secondary bacterial challenge and reduced lung injury measures.
“Interestingly, a recent preclinical study using a murine model of RSV and S. pneumoniae superinfection employed nasal priming by a C. pseudodiphtheriticum strain to augment host defense against the viral infection, which enhanced clearance of secondary bacterial challenge and reduced lung injury measures (140).”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [140]
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RetractedTonetti, F. R., Tomokiyo, M., Fukuyama, K., Elean, M., Moyano, R. O., Yamamuro, H., Shibata, R., Quilodrán-Vega, S., Kurata, S., Villena, J., et al. (2023) · Beneficial Microbes · doi:10.3920/bm2022.0118 · Cited by 5 · see citing works
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Giebeler, L. N., Ehrhardt, C., Häder, A., Lauf, T., Deinhardt‐Emmer, S., & Löffler, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115364 · Cited by 3 · see citing works
Yue, K., Lu, S., Yang, T., Mi, J., He, S., Ma, H., He, Y., Yang, Z., Huang, Y., Song, L., et al. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10665-5 · Cited by 3 · see citing works
- Authors
- Kanmani, P., Clua, P., Vizoso-Pinto, M. G., Rodriguez, C., Alvarez, S., Melnikov, V., Takahashi, H., Kitazawa, H., & Villena, J.
- Affiliations
- Tohoku University (JP)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Central Research Institute of Epidemiology (RU)
- Corresponding author
- Kitazawa, Haruki
- Villena, Julio
- ORCID
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2017-08-23
- Volume
- 8
- Pages
- 1613-1613
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC5572367
- OpenAlex
- W2748606547
- Cited by
- 140
- References
- 40
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 15 · 2023: 3 · 2022: 26 · 2021: 22 · 2020: 19 · 2019: 16 · 2018: 10 · 2017: 2
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Greater South Information System
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (16K21723, 16H05019, 16H06429, 16K21723, 16H06435, 16K15028, 16H06429, Grant numbers: 16H06429, 16K21723, and 16H06435, 16H06429, 16K21723, and 16H06435)
- Japan Society for the Promotion of Science (16K21723, 16H06435, 16H06429, 16K15028, 16H05019)
- Agencia Nacional de Promoción Científica y Tecnológica
- Fondo para la Investigación Científica y Tecnológica (PICT2013)
- Topics
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- Corynebacterium pseudodiphtheriticum, respiratory syncytial virus, Streptococcus pneumoniae, pneumococcal pneumonia, superinfection, TLR3, alveolar macrophages, Th1/Th2 balance, neonatal mice, upper respiratory tract microbiota
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