Cited by 337Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisGenetic Associations and EpidemiologyOccupational and environmental lung diseases

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Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

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Allen, Richard J., Guillen-Guio, Beatriz, Oldham, Justin M., Ma, Shwu-Fan, Dressen, Amy, Paynton, Megan L., Kraven, Luke M., Obeidat, Ma'en, Li, Xuan, Ng, Michael, Braybrooke, Rebecca, Molina-Molina, Maria, Hobbs, Brian D., Putman, Rachel K., Sakornsakolpat, Phuwanat, Booth, Helen L., Fahy, William A., Hart, Simon P., Hill, Mike R., Hirani, Nik, Hubbard, Richard B., McAnulty, Robin J., Millar, Ann B., Navaratnam, Vidyia, Oballa, Eunice, Parfrey, Helen, Saini, Gauri, Whyte, Moira K. B., Zhang, Yingze, Kaminski, Naftali, Adegunsoye, Ayodeji, Strek, Mary E., Neighbors, Margaret, Sheng, Xuting R., Gudmundsson, Gunnar, Gudnason, Vilmundur, Hatabu, Hiroto, Lederer, David J., Manichaikul, Ani, Newell, John D., O’Connor, George T., Ortega, Victor E., Xu, Hanfei, Fingerlin, Tasha E., Bossé, Yohan, Hao, Ke, Joubert, Philippe, Nickle, David C., Sin, Don D., Timens, Wim, Furniss, Dominic, Morris, Andrew P., Zondervan, Krina T., Hall, Ian P., Sayers, Ian, Tobin, Martin D., Maher, Toby M., Cho, Michael H., Hunninghake, Gary M., Schwartz, David A., Yaspan, Brian L., Molyneaux, Philip L., Flores, Carlos, Noth, Imre, Jenkins, R. Gisli, Wain, Louise V.·2020·American Journal of Respiratory and Critical Care Medicine

DOI 10.1164/rccm.201905-1017ocPMC PMC7047454

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Abstract

Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Genome-wide association studies have reported signals of association implicating multiple pathways including host defense, telomere maintenance, signaling, and cell–cell adhesion. Objectives: To improve our understanding of factors that increase IPF susceptibility by identifying previously unreported genetic associations. Methods: We conducted genome-wide analyses across three independent studies and meta-analyzed these results to generate the largest genome-wide association study of IPF to date (2,668 IPF cases and 8,591 controls). We performed replication in two independent studies (1,456 IPF cases and 11,874 controls) and functional analyses (including statistical fine-mapping, investigations into gene expression, and testing for enrichment of IPF susceptibility signals in regulatory regions) to determine putatively causal genes. Polygenic risk scores were used to assess the collective effect of variants not reported as associated with IPF. Measurements and Main Results: We identified and replicated three new genome-wide significant (P < 5 × 10−8) signals of association with IPF susceptibility (associated with altered gene expression of KIF15, MAD1L1, and DEPTOR) and confirmed associations at 11 previously reported loci. Polygenic risk score analyses showed that the combined effect of many thousands of as yet unreported IPF susceptibility variants contribute to IPF susceptibility. Conclusions: The observation that decreased DEPTOR expression associates with increased susceptibility to IPF supports recent studies demonstrating the importance of mTOR signaling in lung fibrosis. New signals of association implicating KIF15 and MAD1L1 suggest a possible role of mitotic spindle-assembly genes in IPF susceptibility.

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UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
Sudlow, C., Gallacher, J., Allen, N., Beral, V., Burton, P., Danesh, J., Downey, P., Elliott, P., Green, J., Landray, M., et al. (2015) · PLOS Medicine · doi:10.1371/journal.pmed.1001779 · Cited by 12,728
The Ensembl Variant Effect Predictor
McLaren, W., Gil, L., Hunt, S. E., Riat, H. S., Ritchie, G. R. S., Thormann, A., Flicek, P., & Cunningham, F. (2016) · Genome Biology · doi:10.1186/s13059-016-0974-4 · Cited by 8,099
An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management
Raghu, G., Collard, H. R., Egan, J. J., Martinez, F. J., Behr, J., Brown, K. K., Colby, T. V., Cordier, J.-F., Flaherty, K. R., Lasky, J. A., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2009-040gl · Cited by 7,186
Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics
Giambartolomei, C., Vukcevic, D., Schadt, E. E., Franke, L., Hingorani, A. D., Wallace, C., & Plagnol, V. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004383 · Cited by 4,261
American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias
(2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.2.ats01 · Cited by 4,196
Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline
Raghu, G., Remy-Jardin, M., Myers, J. L., Richeldi, L., Ryerson, C. J., Lederer, D. J., Behr, J., Cottin, V., Danoff, S. K., Morell, F., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201807-1255st · Cited by 4,103
Self-citation
Genetic effects on gene expression across human tissues
GTEx Consortium (2017) · Nature · doi:10.1038/nature24277 · Cited by 4,036
Robust relationship inference in genome-wide association studies
Manichaikul, A., Mychaleckyj, J. C., Rich, S. S., Daly, K., Sale, M., & Chen, W.-M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq559 · Cited by 3,541
Self-citation
A reference panel of 64,976 haplotypes for genotype imputation
the Haplotype Reference Consortium (2016) · Nature Genetics · doi:10.1038/ng.3643 · Cited by 2,836
A new multipoint method for genome-wide association studies by imputation of genotypes
Marchini, J., Howie, B., Myers, S., McVean, G., & Donnelly, P. (2007) · Nature Genetics · doi:10.1038/ng2088 · Cited by 2,609

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Allen, 2018, Polygenicity of idiopathic pulmonary fibrosis [abstract], Genet Epidemiol, 42, 684
Allen, 2019, Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis [preprint], bioRxiv

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Assayag, D., Adegunsoye, A., Khor, Y. H., Bonella, F., Borie, R., Buendía-Roldán, I., Chaudhuri, N., Gibson, K. F., Johannson, K. A., Kaminski, N., et al. (2025) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202509-2336st · Cited by 7
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Li, X., Li, H., Christenson, S. A., Castro, M., Denlinger, L. C., ERZURUM, S. C., Fahy, J. V., Gaston, B. M., Israel, E., Jarjour, N. N., et al. (2023) · Journal of Asthma · doi:10.1080/02770903.2023.2193631 · Cited by 7
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Chen, Z., Tang, M., Wang, N., Liu, J., Tan, X., Ma, H., Luo, J., & Xie, K. (2025) · BMC Medicine · doi:10.1186/s12916-025-03848-y · Cited by 8
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Authors: Allen, R. J., Guillen-Guio, B., Oldham, J. M., Ma, S.-F., Dressen, A., Paynton, M. L., Kraven, L. M., Obeidat, M., Li, X., Ng, M., Braybrooke, R., Molina-Molina, M., Hobbs, B. D., Putman, R. K., Sakornsakolpat, P., Booth, H. L., Fahy, W. A., Hart, S. P., Hill, M. R., Hirani, N., Hubbard, R. B., McAnulty, R. J., Millar, A. B., Navaratnam, V., Oballa, E., Parfrey, H., Saini, G., Whyte, M. K. B., Zhang, Y., Kaminski, N., Adegunsoye, A., Strek, M. E., Neighbors, M., Sheng, X. R., Gudmundsson, G., Gudnason, V., Hatabu, H., Lederer, D. J., Manichaikul, A., Newell, J. D., O’Connor, G. T., Ortega, V. E., Xu, H., Fingerlin, T. E., Bossé, Y., Hao, K., Joubert, P., Nickle, D. C., Sin, D. D., Timens, W., Furniss, D., Morris, A. P., Zondervan, K. T., Hall, I. P., Sayers, I., Tobin, M. D., Maher, T. M., Cho, M. H., Hunninghake, G. M., Schwartz, D. A., Yaspan, B. L., Molyneaux, P. L., Flores, C., Noth, I., Jenkins, R. G., & Wain, L. V.
Affiliations: University of Leicester (GB)
Unidad de Investigacion, Hospital Universitario Ntra. Sra. de Candelaria and
University of California, Davis (US)
Division of Pulmonary and Critical Care Medicine
Genentech (US)
University of British Columbia (CA)
Nuffield Orthopaedic Centre (GB)
National Institute for Health and Care Research (GB)
Servei de Pneumologia, Laboratori de Pneumologia Experimental, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Barcelona, Spain
Channing Division of Network Medicine
Siriraj Hospital (TH)
University College London Hospitals NHS Foundation Trust (GB)
GlaxoSmithKline (United Kingdom) (GB)
Castle Hill Hospital (GB)
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health
Centre for Inflammation Research (GB)
University College London (GB)
University of Bristol (GB)
Division of Epidemiology and Public Health and
Royal Papworth Hospital (GB)
Nottingham University Hospitals NHS Trust (GB)
University of Pittsburgh (US)
Yale University (US)
University of Chicago (US)
Department of Respiratory Medicine, Landspital University Hospital, Reykjavik, Iceland
University of Iceland (IS)
Brigham and Women's Hospital (US)
Columbia University (US)
University of Virginia (US)
University of Iowa (US)
Boston University (US)
Wake Forest University Health Sciences (US)
National Jewish Health (US)
Institut universitaire de cardiologie et de pneumologie de Québec (CA)
Icahn School of Medicine at Mount Sinai (US)
Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
University Medical Center Groningen (NL)
Centre for Human Genetics (GB)
University of Nottingham (GB)
Universidad de La Laguna (ES)
National Institute for Health Research, Nottingham Biomedical Research Centre and
Corresponding author: Wain, Louise V.
ORCID: Allen, Richard J.
Oldham, Justin M.
Ma, Shwu-Fan
Dressen, Amy
Paynton, Megan L.
Kraven, Luke M.
Obeidat, Ma'en
Li, Xuan
Ng, Michael
Braybrooke, Rebecca
Hobbs, Brian D.
Putman, Rachel K.
Sakornsakolpat, Phuwanat
Fahy, William A.
Hart, Simon P.
Hirani, Nik
Hubbard, Richard B.
McAnulty, Robin J.
Navaratnam, Vidyia
Parfrey, Helen
Saini, Gauri
Whyte, Moira K. B.
Zhang, Yingze
Kaminski, Naftali
Adegunsoye, Ayodeji
Strek, Mary E.
Neighbors, Margaret
Gudnason, Vilmundur
Hatabu, Hiroto
Lederer, David J.
Manichaikul, Ani
Newell, John D.
O’Connor, George T.
Ortega, Victor E.
Xu, Hanfei
Fingerlin, Tasha E.
Bossé, Yohan
Hao, Ke
Joubert, Philippe
Nickle, David C.
Sin, Don D.
Timens, Wim
Furniss, Dominic
Morris, Andrew P.
Zondervan, Krina T.
Hall, Ian P.
Sayers, Ian
Tobin, Martin D.
Maher, Toby M.
Cho, Michael H.
Hunninghake, Gary M.
Schwartz, David A.
Yaspan, Brian L.
Molyneaux, Philip L.
Flores, Carlos
Noth, Imre
Wain, Louise V.
Venue: American Journal of Respiratory and Critical Care Medicine
Publisher: Oxford University Press (OUP)
Published: 2020-03-01
Volume: 201
Issue: 5
Pages: 564-574
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/rccm.201905-1017oc
PMC: PMC7047454
OpenAlex: W2983449145
Cited by: 329
References: 62
Citations by year: 2026: 37 · 2025: 49 · 2024: 37 · 2023: 67 · 2022: 53 · 2021: 54 · 2020: 28
FWCI: 26.47
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor, 2194 d)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion, cc-by)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
Edinburgh Research Explorer (University of Edinburgh) (acceptedVersion, other-oa)
Repository@Hull (Worktribe) (University of Hull) (submittedVersion, cc-by)
Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
UCL Discovery (University College London) (submittedVersion)
Figshare (submittedVersion, cc-by)
Opin vísindi (Opin vísindi) (submittedVersion, cc-by)
Research Explorer (The University of Manchester) (submittedVersion, cc-by-nc-nd)
Spiral (Imperial College London) (submittedVersion, other-oa)
Hirsla (Landspítali University Hospital) (submittedVersion, other-oa)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Funders: U.S. Department of Veterans Affairs (CDA13-017)
Wellcome Trust (WT202849/Z/16/Z, 95161, /Z/11/Z, WT202849, 097152, 097152/Z/11/Z)
Broad Institute
Ministerio de Ciencia, Innovación y Universidades (RTC-2017-6471-1, OA17/008, RTC-2017, PT17/0019)
Instituto Tecnológico y de Energías Renovables (OA17/008, RTC-2017-6471-1)
Michael Smith Health Research BC
National Institute for Health and Care Research (RP-2017-08-ST2-014, NF-SI-0617-10096, CS-2013-13-017)
British Lung Foundation (C17-3, WT202849/Z/16/Z)
Asthma and Lung UK (RP-2017-08-ST2-014, AUK-PG-2013-188)
University of Leicester
European Commission (2013-2016, PT17/0019)
Agencia Canaria de Investigación, Innovación y Sociedad de la Información (OA17/008, TESIS2015010057)
National Institutes of Health (n01hc95164-17-0-1, UL1TR001420, n01hc95165-34-0-1, n01hc95161-24-0-1, n01hc095169-003, N01-HC- 95166, 2013-2016, n01hc95166-21-0-1, N01-HC9-5168, R01130974, n01hc95162-31-0-1, n01hc95168-27-0-1, n01hc95160-18-0-1, n01hc095167-000, N01-HC- 95159, UL1TR001079, n01hc95163-22-0-1, PT17/0019, HHSN263201500003I, n02hl64278-6-0-0, HHSN268201500003I, n01hc95159-40-0-1, UL1TR000040, UL1-TR-, N01‐HC‐95161, N01- HC-95163, N01- HC-95165, N01‐HC‐95160, N01 HC95164, N01-HC-95167, N02-HL-64278, N01-HC95162, N01‐HC‐95169, HL136928, DK-063491, UL1TR001863, UL1TR001881)
Medical Research Council (MC_PC_12010, G1000861, MR/N005953/1)
Instituto de Salud Carlos III (2013-2016, PT17/0019)
European Regional Development Fund (RTC-2017-6471-1, PT17/0019, of the PE I+D+i 2013-2016, RTC-2017, PE I+D+i 2013-2016, OA17/008, PT17/0019, 000040, 2013-2016)
Agencia Estatal de Investigación (RTC-2017-6471-1)
NIHR Leicester Biomedical Research Centre
NIHR Nottingham Biomedical Research Centre
National Heart, Lung, and Blood Institute (DK-063491, R01HL130796, N01 HC-95159, N01-HC-95160, R01HL097163, N01-HC095169, RTC-2017-6471-1, WT202849/Z/16/Z, N01 HC-95168, N01-HC-095165, R01HL113264, HL131565, N01 HC95167, K23HL138190, (N01-HC-95163, N01 HC095163, N01 HC-95161, N01 HC95165, N01HC95164, HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95167, N01-HC-95168, N01-HC-95169, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, R01HL137927, R01HL103676, N02 HL064278, CS-2013-13-017, UG3HL151865, N01-HC-95167, N01-HC-95168, UL1-TR-, N01-HC-095159, N01-HC, N01 HC095168, N02- HL-64278, N01-HC-095162, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95161, N01-HC-95162, N01-HC-95163, HC-95168, N01-HC-095161, HL136928, R01HL111024, HHSN268201500003C, HHSN26820150 0003I, R01HL149836, HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01, N01 HC095167, C17-3, K08HL136928, K08HL140087, N01-HC-095160, R01HL137234, N01 HC095166, HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01 HC095164, UL1-TR-000040, UL1-TR-001079, UL1-TR-001420, N01‐HC‐95166, R33HL120770, P01HL092870, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, RP-2017-08-ST2-014, N01-HC-95159, N01-HC-95160, N01 HC-95162, R01HL131565, HC95159, UH3HL151865, R01HL130974, T32HL007085, R01HL135142, HL64278, N01 HC95169)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK063491)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
Keywords: idiopathic pulmonary fibrosis, genetic susceptibility, genome-wide association study, KIF15, MAD1L1, DEPTOR, mTOR signaling, mitotic spindle assembly, polygenic risk score, gene expression, regulatory elements, pulmonary fibrosis
MeSH terms: Aged, Female, Humans, Male, Middle Aged, Spindle Apparatus, Signal Transduction, Gene Expression, Case-Control Studies, Kinesins, Risk Assessment, Cell Cycle Proteins, Genetic Predisposition to Disease, Intracellular Signaling Peptides and Proteins, Idiopathic Pulmonary Fibrosis, Genome-Wide Association Study, TOR Serine-Threonine Kinases

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Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

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