Cited by 337Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisGenetic Associations and EpidemiologyOccupational and environmental lung diseases

The DOI matches its Crossref record; 61 of the 62 references it cites were found in a registry or an index.

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

Open access

Allen, Richard J., Guillen-Guio, Beatriz, Oldham, Justin M., Ma, Shwu-Fan, Dressen, Amy, Paynton, Megan L., Kraven, Luke M., Obeidat, Ma'en, Li, Xuan, Ng, Michael, Braybrooke, Rebecca, Molina-Molina, Maria, Hobbs, Brian D., Putman, Rachel K., Sakornsakolpat, Phuwanat, Booth, Helen L., Fahy, William A., Hart, Simon P., Hill, Mike R., Hirani, Nik, Hubbard, Richard B., McAnulty, Robin J., Millar, Ann B., Navaratnam, Vidyia, Oballa, Eunice, Parfrey, Helen, Saini, Gauri, Whyte, Moira K. B., Zhang, Yingze, Kaminski, Naftali, Adegunsoye, Ayodeji, Strek, Mary E., Neighbors, Margaret, Sheng, Xuting R., Gudmundsson, Gunnar, Gudnason, Vilmundur, Hatabu, Hiroto, Lederer, David J., Manichaikul, Ani, Newell, John D., O’Connor, George T., Ortega, Victor E., Xu, Hanfei, Fingerlin, Tasha E., Bossé, Yohan, Hao, Ke, Joubert, Philippe, Nickle, David C., Sin, Don D., Timens, Wim, Furniss, Dominic, Morris, Andrew P., Zondervan, Krina T., Hall, Ian P., Sayers, Ian, Tobin, Martin D., Maher, Toby M., Cho, Michael H., Hunninghake, Gary M., Schwartz, David A., Yaspan, Brian L., Molyneaux, Philip L., Flores, Carlos, Noth, Imre, Jenkins, R. Gisli, Wain, Louise V.·2020·American Journal of Respiratory and Critical Care Medicine

DOI 10.1164/rccm.201905-1017ocPMC PMC7047454

Published version of a preprint

Open this paper in CoChat — free account

Abstract

Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Genome-wide association studies have reported signals of association implicating multiple pathways including host defense, telomere maintenance, signaling, and cell–cell adhesion. Objectives: To improve our understanding of factors that increase IPF susceptibility by identifying previously unreported genetic associations. Methods: We conducted genome-wide analyses across three independent studies and meta-analyzed these results to generate the largest genome-wide association study of IPF to date (2,668 IPF cases and 8,591 controls). We performed replication in two independent studies (1,456 IPF cases and 11,874 controls) and functional analyses (including statistical fine-mapping, investigations into gene expression, and testing for enrichment of IPF susceptibility signals in regulatory regions) to determine putatively causal genes. Polygenic risk scores were used to assess the collective effect of variants not reported as associated with IPF. Measurements and Main Results: We identified and replicated three new genome-wide significant (P < 5 × 10−8) signals of association with IPF susceptibility (associated with altered gene expression of KIF15, MAD1L1, and DEPTOR) and confirmed associations at 11 previously reported loci. Polygenic risk score analyses showed that the combined effect of many thousands of as yet unreported IPF susceptibility variants contribute to IPF susceptibility. Conclusions: The observation that decreased DEPTOR expression associates with increased susceptibility to IPF supports recent studies demonstrating the importance of mTOR signaling in lung fibrosis. New signals of association implicating KIF15 and MAD1L1 suggest a possible role of mitotic spindle-assembly genes in IPF susceptibility.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1164/rccm.201905-1017oc

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
Sudlow, C., Gallacher, J., Allen, N., Beral, V., Burton, P., Danesh, J., Downey, P., Elliott, P., Green, J., Landray, M., et al. (2015) · PLOS Medicine · doi:10.1371/journal.pmed.1001779 · Cited by 12,728
The Ensembl Variant Effect Predictor
McLaren, W., Gil, L., Hunt, S. E., Riat, H. S., Ritchie, G. R. S., Thormann, A., Flicek, P., & Cunningham, F. (2016) · Genome Biology · doi:10.1186/s13059-016-0974-4 · Cited by 8,099
An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management
Raghu, G., Collard, H. R., Egan, J. J., Martinez, F. J., Behr, J., Brown, K. K., Colby, T. V., Cordier, J.-F., Flaherty, K. R., Lasky, J. A., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2009-040gl · Cited by 7,186
Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics
Giambartolomei, C., Vukcevic, D., Schadt, E. E., Franke, L., Hingorani, A. D., Wallace, C., & Plagnol, V. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004383 · Cited by 4,261
American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias
(2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.2.ats01 · Cited by 4,196
Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline
Raghu, G., Remy-Jardin, M., Myers, J. L., Richeldi, L., Ryerson, C. J., Lederer, D. J., Behr, J., Cottin, V., Danoff, S. K., Morell, F., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201807-1255st · Cited by 4,103
Self-citation
Genetic effects on gene expression across human tissues
GTEx Consortium (2017) · Nature · doi:10.1038/nature24277 · Cited by 4,036
Robust relationship inference in genome-wide association studies
Manichaikul, A., Mychaleckyj, J. C., Rich, S. S., Daly, K., Sale, M., & Chen, W.-M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq559 · Cited by 3,541
Self-citation
A reference panel of 64,976 haplotypes for genotype imputation
the Haplotype Reference Consortium (2016) · Nature Genetics · doi:10.1038/ng.3643 · Cited by 2,836
A new multipoint method for genome-wide association studies by imputation of genotypes
Marchini, J., Howie, B., Myers, S., McVean, G., & Donnelly, P. (2007) · Nature Genetics · doi:10.1038/ng2088 · Cited by 2,609

Flagged first, then by citations

Show all 62 references

1 of the 62 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Allen, 2018, Polygenicity of idiopathic pulmonary fibrosis [abstract], Genet Epidemiol, 42, 684
Allen, 2019, Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis [preprint], bioRxiv

Sorted by citations

Items 301–337 of 337

COPD-associated proteins as biomarkers and drug targets: Insights from genetic and proteomic analyses
Lin, X., Zheng, Q., Ma, J., Ouyang, W., & Chen, B. (2025) · Medicine · doi:10.1097/md.0000000000045102
Telomere integrity, epigenetic aging, and genetic burden shape biological aging trajectories in idiopathic pulmonary fibrosis
Campisi, M., Cannella, L., Liviero, F., Tamiazzo, F., Balestro, E., Spagnolo, P., & Pavanello, S. (2026) · npj Aging · doi:10.1038/s41514-026-00434-1
Genome-wide analysis of tandem repeat variation identifies SLC15A4 as a susceptibility gene for idiopathic pulmonary fibrosisPreprint
Oketch, J. W., Albahimah, A., Barca, A., Allen, R. J., Shrine, N. R. G., Walewski, B., Sidekli, O., Alyassi, A., Romano, A., Jenkins, G. R., et al. (2025) · medRxiv · doi:10.1101/2025.11.25.25340948
Self-citation
Common and rare variant analyses reveal genetic factors underlying idiopathic pulmonary fibrosis and its shared aetiology with severe COVID-19
Kousathanas, A., Odhams, C. A., Cook, J. P., Hu, Y., Klee, S., Erzurumluoglu, A. M., Ramírez, F., Mayr, C. H., Schäfer, D., Beck, L., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.106048
Additional file 1 of The FoxP1 gene regulates lung function, production of matrix metalloproteinases and inflammatory mediators, and viability of lung epithelia
Andreas, A. R., Maloy, A., Nyunoya, T., Zhang, Y., & Chandra, D. (2022) · Figshare · doi:10.6084/m9.figshare.21316163
Self-citation
Additional file 1 of Lung tissue shows divergent gene expression between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
Ghosh, A. J., Hobbs, B. D., Yun, J. H., Saferali, A., Moll, M. R., Xu, Z., Chase, R. P., Morrow, J. D., Ziniti, J. P., Sciurba, F., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19634917
Self-citation
Additional file 4 of An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility
Wang, L., Balmat, T. J., Antonia, A. L., Constantine, F. J., Henao, R., Burke, T. W., Ingham, A., McClain, M. T., Tsalik, E. L., Ko, E. R., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14608661
Additional file 1 of ZCCHC8 p.P410A disrupts nucleocytoplasmic localization, promoting idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease
Wang, C.-Y., Chang, S.-H., Hu, C.-F., Hu, Y.-Q., Luo, H., Liu, L., & Fan, L.-L. (2024) · Figshare · doi:10.6084/m9.figshare.26981963
Additional file 1 of An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility
Wang, L., Balmat, T. J., Antonia, A. L., Constantine, F. J., Henao, R., Burke, T. W., Ingham, A., McClain, M. T., Tsalik, E. L., Ko, E. R., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14608652
Additional file 5 of An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility
Wang, L., Balmat, T. J., Antonia, A. L., Constantine, F. J., Henao, R., Burke, T. W., Ingham, A., McClain, M. T., Tsalik, E. L., Ko, E. R., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14608664
Additional file 2 of An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility
Wang, L., Balmat, T. J., Antonia, A. L., Constantine, F. J., Henao, R., Burke, T. W., Ingham, A., McClain, M. T., Tsalik, E. L., Ko, E. R., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14608655
Additional file 1 of Lung histopathological findings in COVID-19 disease – a systematic review
Pannone, G., Caponio, V. C. A., Stefano, I. S. D., Ramunno, M. A., Meccariello, M., Agostinone, A., Pedicillo, M. C., Troiano, G., Zhurakivska, K., Cassano, T., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14608535
Additional file 1 of KIF15 missense variant is associated with the early onset of idiopathic pulmonary fibrosis
Hollmén, M., Laaka, A., Partanen, J. J., Koskela, J. T., Sutinen, E., Kaarteenaho, R., Ainola, M., & Myllärniemi, M. (2024) · Figshare · doi:10.6084/m9.figshare.26621335
Multi-omics of chronic obstructive pulmonary disease: from genetic and metabolomic disorders to personalized medicine
Nikitina, L. Y., Buikin, S. V., Робертович, В. В., Гасанов, М. З., & Авдеев, С. Н. (2025) · South Russian Journal of Therapeutic Practice · doi:10.21886/2712-8156-2025-6-4-28-42
MUC5B rs35705950 and its association with survival in Brazilian patients with idiopathic pulmonary fibrosis: A longitudinal cohort study
Rufino, R., Faria, L., Alves, M. R., Araujo, L. R. M., Palermo, L., Bessa, E. J. C., Rangel, B., Lopes, M. C., Rufino, M. C., da Costa, C. H., et al. (2026) · PLoS ONE · doi:10.1371/journal.pone.0341661
Assessment of mosaic loss of chromosome Y in pulmonary fibrosis reveals limited association with susceptibility or disease severity
Wang, D., Hadad, N., Moss, S., López-Jiménez, E. A., Johnson, S. R., Maher, T. M., Molyneaux, P. L., Zhao, Y., Perry, J. R. B., Wolters, P. J., et al. (2026) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2025-003846
Self-citation
Contribution of dominant and recessive model effects to the genetic architecture of Idiopathic Pulmonary FibrosisPreprint
Hernández-Beeftink, T., Donoghue, L. J., Izquierdo, A. G., Moss, S. T., Chin, D., Guillén‐Guío, B., Bhatti, K. F., Biddie, S. C., Shrine, N. R. G., Packer, R. J., et al. (2026) · medRxiv · doi:10.64898/2026.02.18.26345897
Self-citation
Relationship between habitual glucosamine use and risk of incident idiopathic pulmonary fibrosis with the modification effect of genetic susceptibility: a prospective cohort study
Yang, L., Xie, Y., Yao, Y., Yin, H., Shang, B., Yang, S., You, X., & Ma, J. (2026) · European Journal of Nutrition · doi:10.1007/s00394-026-03933-9
Disentangling the Shared and Differential Genetic Architecture Between COVID-19 and Other Respiratory Disorders: A Multi-Omics Genome-Wide AnalysisPreprint
Xue, X., Lin, Y., Feng, Y., & So, H. (2026) · medRxiv · doi:10.64898/2026.03.21.26348591
Causal and shared genetic insights into severe COVID-19 and idiopathic pulmonary fibrosis
Lin, S., Dang, X., Kou, X., Zhang, X., Ding, X., & Li, X. (2026) · iScience · doi:10.1016/j.isci.2026.115494
Self-citation
Treatable traits in interstitial lung disease: towards precision medicine
Avitzur, N., Marinescu, D.-C., Churg, A., Goobie, G. C., Hague, C. J., Müller, N. L., Wright, J. L., & Ryerson, C. J. (2026) · Thorax · doi:10.1136/thorax-2024-222058
Epigenome-wide Mendelian randomization with multi-omics validation identifies epigenetic drivers of idiopathic pulmonary fibrosis
Li, Z., Hong, L., Lv, X., Yang, S.-Y., Ye, F., Huang, L.-J., Jiang, S., & Zhao, H.-Y. (2026) · Communications Biology · doi:10.1038/s42003-026-10033-1
Proteome-wide Mendelian randomisation of lung function to identify potential therapeutic targets for respiratory disease
Chen, J. M., Shrine, N. R. G., Coley, K., Packer, R. J., Edris, A., Izquierdo, A. G., Lim, B., Lee, M., Dudbridge, F., Walters, R. G., et al. (2026) · ERJ Open Research · doi:10.1183/23120541.00828-2025
Self-citation
Emerging multisystem disease mechanisms of e-cigarette vaping on human health
Tareq, M. M. I., Nair, S., & He, G. (2026) · Toxicology Reports · doi:10.1016/j.toxrep.2026.102282
Molecular mechanisms of environmental risk factors for interstitial lung disease
Goobie, G. C. (2026) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000001286
Genetically supported drug target prioritization for rare diseases
Chen, R. E., Duffy, Á., Mort, M. E., Cooper, D. N., Rocheleau, G., Jordan, D. M., & Do, R. (2026) · Genome Medicine · doi:10.1186/s13073-026-01671-5
Disease-associated genetic variants can cause missense effects in tissue-specific protein isoforms
Weykopf, G., Badonyi, M., Friman, E. T., Nguyen, J. M. H., Ioannou, A., Livesey, B., Coutts, A. A., Hird, E. F., Wham, M., Stanton, C. M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-74280-w · Cited by 2
DPP9-mediated inflammasome repression protects against checkpoint inhibitor lung toxicityPreprint
Brewer, J. R., Han, A., Nassar, A. H., Farhat, E. B., Blackburn, H. N., Xiao, T., Mirza, H., Mowel, W. K., Sefik, E., Hartner, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.30.735609
Translational prioritization of genetically supported candidate targets and pharmacological annotations for chronic lung diseases: a single-cell eQTL-guided multi-cohort study
Li, R., Cheng, J., Liu, Y., Zhang, X., & Zhang, Z. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08625-w
Identifying severe COVID-19 risk variants modulating enhancer reporter activity in lung cells
Weykopf, G., Bickmore, W. A., Biddie, S. C., & Friman, E. T. (2026) · PLoS Genetics · doi:10.1371/journal.pgen.1012222
Causal Association Between Idiopathic Pulmonary Fibrosis and Coronary Artery Disease: A Bidirectional Two-Sample Mendelian Randomization
Yang, L., Zhao, X., Feng, T., & Li, J. (2026) · British Journal of Hospital Medicine · doi:10.31083/bjhm56025
Early‐life internalizing behavioral trajectories and childhood‐onset asthma: An epigenetic link
Yoon, J., Lee, S., Kim, J., Lee, S.-Y., Oh, H. Y., 정성수, Paek, E. Y., Lee, D. K., Choi, E. J., Song, K.-B., et al. (2026) · Pediatric Allergy and Immunology · doi:10.1111/pai.70436
Multi-omics approaches in idiopathic pulmonary fibrosis: from molecular mechanisms to therapeutic targets and precision medicine
Hu, W., & Wang, X. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1899849
Interstitial lung abnormalities: a mechanistic window into early fibrotic lung disease
Selvarajah, B., Buconjic, D., & Hewitt, R. J. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1867568 · Cited by 1
Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency
Xiao, T., Brewer, J. R., Carlino, M. J., Han, A., Takabe, Y. J., Lee, C., Zhang, F., Chen, M., Blackburn, H. N., Nassar, A. H., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci207530
Genetic determinants of protein phosphorylation in humansPreprint
Needham, E. J., Zhao, J. H., Hirschmüller, N., Wolford, C., Jiang, X., & Butterworth, A. S. (2026) · medRxiv · doi:10.64898/2026.10.17.26365814
BindingDB Entry 50021579: Emerging opportunities to treat idiopathic pulmonary fibrosis: Design, discovery, and optimizations of small-molecule drugs targeting fibrogenic pathways.
BindingDB (2025) · UC San Diego · doi:10.7270/q2pg1xbp

Authors: Allen, R. J., Guillen-Guio, B., Oldham, J. M., Ma, S.-F., Dressen, A., Paynton, M. L., Kraven, L. M., Obeidat, M., Li, X., Ng, M., Braybrooke, R., Molina-Molina, M., Hobbs, B. D., Putman, R. K., Sakornsakolpat, P., Booth, H. L., Fahy, W. A., Hart, S. P., Hill, M. R., Hirani, N., Hubbard, R. B., McAnulty, R. J., Millar, A. B., Navaratnam, V., Oballa, E., Parfrey, H., Saini, G., Whyte, M. K. B., Zhang, Y., Kaminski, N., Adegunsoye, A., Strek, M. E., Neighbors, M., Sheng, X. R., Gudmundsson, G., Gudnason, V., Hatabu, H., Lederer, D. J., Manichaikul, A., Newell, J. D., O’Connor, G. T., Ortega, V. E., Xu, H., Fingerlin, T. E., Bossé, Y., Hao, K., Joubert, P., Nickle, D. C., Sin, D. D., Timens, W., Furniss, D., Morris, A. P., Zondervan, K. T., Hall, I. P., Sayers, I., Tobin, M. D., Maher, T. M., Cho, M. H., Hunninghake, G. M., Schwartz, D. A., Yaspan, B. L., Molyneaux, P. L., Flores, C., Noth, I., Jenkins, R. G., & Wain, L. V.
Affiliations: University of Leicester (GB)
Unidad de Investigacion, Hospital Universitario Ntra. Sra. de Candelaria and
University of California, Davis (US)
Division of Pulmonary and Critical Care Medicine
Genentech (US)
University of British Columbia (CA)
Nuffield Orthopaedic Centre (GB)
National Institute for Health and Care Research (GB)
Servei de Pneumologia, Laboratori de Pneumologia Experimental, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Barcelona, Spain
Channing Division of Network Medicine
Siriraj Hospital (TH)
University College London Hospitals NHS Foundation Trust (GB)
GlaxoSmithKline (United Kingdom) (GB)
Castle Hill Hospital (GB)
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health
Centre for Inflammation Research (GB)
University College London (GB)
University of Bristol (GB)
Division of Epidemiology and Public Health and
Royal Papworth Hospital (GB)
Nottingham University Hospitals NHS Trust (GB)
University of Pittsburgh (US)
Yale University (US)
University of Chicago (US)
Department of Respiratory Medicine, Landspital University Hospital, Reykjavik, Iceland
University of Iceland (IS)
Brigham and Women's Hospital (US)
Columbia University (US)
University of Virginia (US)
University of Iowa (US)
Boston University (US)
Wake Forest University Health Sciences (US)
National Jewish Health (US)
Institut universitaire de cardiologie et de pneumologie de Québec (CA)
Icahn School of Medicine at Mount Sinai (US)
Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
University Medical Center Groningen (NL)
Centre for Human Genetics (GB)
University of Nottingham (GB)
Universidad de La Laguna (ES)
National Institute for Health Research, Nottingham Biomedical Research Centre and
Corresponding author: Wain, Louise V.
ORCID: Allen, Richard J.
Oldham, Justin M.
Ma, Shwu-Fan
Dressen, Amy
Paynton, Megan L.
Kraven, Luke M.
Obeidat, Ma'en
Li, Xuan
Ng, Michael
Braybrooke, Rebecca
Hobbs, Brian D.
Putman, Rachel K.
Sakornsakolpat, Phuwanat
Fahy, William A.
Hart, Simon P.
Hirani, Nik
Hubbard, Richard B.
McAnulty, Robin J.
Navaratnam, Vidyia
Parfrey, Helen
Saini, Gauri
Whyte, Moira K. B.
Zhang, Yingze
Kaminski, Naftali
Adegunsoye, Ayodeji
Strek, Mary E.
Neighbors, Margaret
Gudnason, Vilmundur
Hatabu, Hiroto
Lederer, David J.
Manichaikul, Ani
Newell, John D.
O’Connor, George T.
Ortega, Victor E.
Xu, Hanfei
Fingerlin, Tasha E.
Bossé, Yohan
Hao, Ke
Joubert, Philippe
Nickle, David C.
Sin, Don D.
Timens, Wim
Furniss, Dominic
Morris, Andrew P.
Zondervan, Krina T.
Hall, Ian P.
Sayers, Ian
Tobin, Martin D.
Maher, Toby M.
Cho, Michael H.
Hunninghake, Gary M.
Schwartz, David A.
Yaspan, Brian L.
Molyneaux, Philip L.
Flores, Carlos
Noth, Imre
Wain, Louise V.
Venue: American Journal of Respiratory and Critical Care Medicine
Publisher: Oxford University Press (OUP)
Published: 2020-03-01
Volume: 201
Issue: 5
Pages: 564-574
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/rccm.201905-1017oc
PMC: PMC7047454
OpenAlex: W2983449145
Cited by: 329
References: 62
Citations by year: 2026: 37 · 2025: 49 · 2024: 37 · 2023: 67 · 2022: 53 · 2021: 54 · 2020: 28
FWCI: 26.47
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor, 2194 d)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion, cc-by)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
Edinburgh Research Explorer (University of Edinburgh) (acceptedVersion, other-oa)
Repository@Hull (Worktribe) (University of Hull) (submittedVersion, cc-by)
Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
UCL Discovery (University College London) (submittedVersion)
Figshare (submittedVersion, cc-by)
Opin vísindi (Opin vísindi) (submittedVersion, cc-by)
Research Explorer (The University of Manchester) (submittedVersion, cc-by-nc-nd)
Spiral (Imperial College London) (submittedVersion, other-oa)
Hirsla (Landspítali University Hospital) (submittedVersion, other-oa)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Funders: U.S. Department of Veterans Affairs (CDA13-017)
Wellcome Trust (WT202849/Z/16/Z, 95161, /Z/11/Z, WT202849, 097152, 097152/Z/11/Z)
Broad Institute
Ministerio de Ciencia, Innovación y Universidades (RTC-2017-6471-1, OA17/008, RTC-2017, PT17/0019)
Instituto Tecnológico y de Energías Renovables (OA17/008, RTC-2017-6471-1)
Michael Smith Health Research BC
National Institute for Health and Care Research (RP-2017-08-ST2-014, NF-SI-0617-10096, CS-2013-13-017)
British Lung Foundation (C17-3, WT202849/Z/16/Z)
Asthma and Lung UK (RP-2017-08-ST2-014, AUK-PG-2013-188)
University of Leicester
European Commission (2013-2016, PT17/0019)
Agencia Canaria de Investigación, Innovación y Sociedad de la Información (OA17/008, TESIS2015010057)
National Institutes of Health (n01hc95164-17-0-1, UL1TR001420, n01hc95165-34-0-1, n01hc95161-24-0-1, n01hc095169-003, N01-HC- 95166, 2013-2016, n01hc95166-21-0-1, N01-HC9-5168, R01130974, n01hc95162-31-0-1, n01hc95168-27-0-1, n01hc95160-18-0-1, n01hc095167-000, N01-HC- 95159, UL1TR001079, n01hc95163-22-0-1, PT17/0019, HHSN263201500003I, n02hl64278-6-0-0, HHSN268201500003I, n01hc95159-40-0-1, UL1TR000040, UL1-TR-, N01‐HC‐95161, N01- HC-95163, N01- HC-95165, N01‐HC‐95160, N01 HC95164, N01-HC-95167, N02-HL-64278, N01-HC95162, N01‐HC‐95169, HL136928, DK-063491, UL1TR001863, UL1TR001881)
Medical Research Council (MC_PC_12010, G1000861, MR/N005953/1)
Instituto de Salud Carlos III (2013-2016, PT17/0019)
European Regional Development Fund (RTC-2017-6471-1, PT17/0019, of the PE I+D+i 2013-2016, RTC-2017, PE I+D+i 2013-2016, OA17/008, PT17/0019, 000040, 2013-2016)
Agencia Estatal de Investigación (RTC-2017-6471-1)
NIHR Leicester Biomedical Research Centre
NIHR Nottingham Biomedical Research Centre
National Heart, Lung, and Blood Institute (DK-063491, R01HL130796, N01 HC-95159, N01-HC-95160, R01HL097163, N01-HC095169, RTC-2017-6471-1, WT202849/Z/16/Z, N01 HC-95168, N01-HC-095165, R01HL113264, HL131565, N01 HC95167, K23HL138190, (N01-HC-95163, N01 HC095163, N01 HC-95161, N01 HC95165, N01HC95164, HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95167, N01-HC-95168, N01-HC-95169, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, R01HL137927, R01HL103676, N02 HL064278, CS-2013-13-017, UG3HL151865, N01-HC-95167, N01-HC-95168, UL1-TR-, N01-HC-095159, N01-HC, N01 HC095168, N02- HL-64278, N01-HC-095162, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95161, N01-HC-95162, N01-HC-95163, HC-95168, N01-HC-095161, HL136928, R01HL111024, HHSN268201500003C, HHSN26820150 0003I, R01HL149836, HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01, N01 HC095167, C17-3, K08HL136928, K08HL140087, N01-HC-095160, R01HL137234, N01 HC095166, HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01 HC095164, UL1-TR-000040, UL1-TR-001079, UL1-TR-001420, N01‐HC‐95166, R33HL120770, P01HL092870, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, RP-2017-08-ST2-014, N01-HC-95159, N01-HC-95160, N01 HC-95162, R01HL131565, HC95159, UH3HL151865, R01HL130974, T32HL007085, R01HL135142, HL64278, N01 HC95169)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK063491)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
Keywords: idiopathic pulmonary fibrosis, genetic susceptibility, genome-wide association study, KIF15, MAD1L1, DEPTOR, mTOR signaling, mitotic spindle assembly, polygenic risk score, gene expression, regulatory elements, pulmonary fibrosis
MeSH terms: Aged, Female, Humans, Male, Middle Aged, Spindle Apparatus, Signal Transduction, Gene Expression, Case-Control Studies, Kinesins, Risk Assessment, Cell Cycle Proteins, Genetic Predisposition to Disease, Intracellular Signaling Peptides and Proteins, Idiopathic Pulmonary Fibrosis, Genome-Wide Association Study, TOR Serine-Threonine Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks