Cited by 892Redox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative MechanismsNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 66 of the 67 references it cites were found in a registry or an index.

Reactive Oxygen Species and Cell Signaling: Respiratory Burst in Macrophage Signaling

Forman, Henry Jay, Torres, Martine·2002·American Journal of Respiratory and Critical Care Medicine

DOI 10.1164/rccm.2206007

Open this paper in CoChat — free account

Abstract

Phagocytes such as neutrophils and macrophages produce reactive oxygen species (ROS) during phagocytosis or stimulation with a wide variety of agents through activation of nicotinamide adenine dinucleotide phosphate reduced (NADPH) oxidase that is assembled at the plasma membrane from resident plasma membrane and cytosolic protein components. One of the subunits of the phagocyte NADPH oxidase is now recognized as a member of a family of NADPH oxidases, or NOX, present in cells other than phagocytes. Physiologic generation of ROS has been implicated in a variety of physiologic responses from transcriptional activation to cell proliferation and apoptosis. The increase in superoxide and hydrogen peroxide (H2O2) that results from stimulation of the NADPH oxidase is transient, in part due to the presence of the antioxidant enzymes, which return their concentrations to the prestimulation steady state level. Thus, the antioxidant enzymes may function in the “turn-off” phase of signal transduction by ROS. During its transient elevation, H2O2 may act as a modifier of key signaling enzymes through reversible oxidation of critical thiols. The rapid reaction of thiols with H2O2 when in their unprotonated state would provide a potential mechanism for the specificity that is necessary for physiologic cell signaling.

Integrity signals

Registry

Crossref · 10.1164/rccm.2206007

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
Pearson, G. W., Robinson, F. L., Gibson, T. B., Xu, B.-E., Karandikar, M. S., Berman, K. S., & Cobb, M. H. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.2.0428 · Cited by 4,111
AP-1 as a regulator of cell life and death
Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961
Reactive oxygen species in cell signaling
Thannickal, V. J., & Fanburg, B. L. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.6.l1005 · Cited by 2,950
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent
Babior, B. M., Kipnes, R. S., & Curnutte, J. T. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107236 · Cited by 2,931
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886
Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1
Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K., & Ichijo, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.9.2596 · Cited by 2,377
Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts
Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., & Goldschmidt-Clermont, P. J. (1997) · Science · doi:10.1126/science.275.5306.1649 · Cited by 1,588
Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro
Abate, C., Patel, L., Rauscher, F. J., & Curran, T. (1990) · Science · doi:10.1126/science.2118682 · Cited by 1,573

Show all 67 references

Research works printed but not linked: 4

2000, Mutat Res, 448, 179
2001, Endocr Rev, 22, 153
1996, J Biol Chem, 271, 4138, 10.1074/jbc.271.8.4138 · DOI
1996, Int J Pediatr Hematol Oncol, 3, 387

Sorted by citations

Items 201–300 of 892

Tamoxifen reduces fat mass by boosting reactive oxygen species
Liu, L., Zou, P., Zheng, L., Linarelli, L. E., Amarell, S., Passaro, A. P., Liu, D., & Cheng, Z. (2015) · Cell Death and Disease · doi:10.1038/cddis.2014.553 · Cited by 80
“production and also respond sensitively to ROS- and TNFαmediated signaling cascades.(46,48) The effect of Tam on fat mass in humans, for example,”
Background
Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice
Teufelhofer, O. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh320 · Cited by 79
Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia
Shukla, S. K., Markov, S. D., Attri, K. S., Vernucci, E., King, R. J., Dasgupta, A., Grandgenett, P. M., Hollingsworth, M. A., Singh, P. K., Yu, F., et al. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.04.017 · Cited by 81
Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivo
Zhang, W., Hao, W., & Frei, B. B. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.12.003 · Cited by 77
“ROS also modulate a number of cell signaling pathways resulting in transcription factor activation [17,18].”
Background
Generation, structure and reactions of sulfenic acid anions
O’Donnell, J. S., & Schwan, A. L. (2004) · Journal of Sulfur Chemistry · doi:10.1080/1741599042000220761 · Cited by 77
Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia
Yang, C., Lee, H., Ji-Yeon, L., Kim, J., Lee, S. J., Shin, D., Lee, Y., Lee, D., Benna, J. E., & Jo, E. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-27 · Cited by 77
“Activation of the NADPH oxidase pathway initiates an intracellular ROS signaling pathway that amplifies the production of proinflammatory cytokines, such as TNF-α [21].”
Background
First Line of Defense: Innate Cell-Mediated Control of Pulmonary Aspergillosis
Espinosa, V., & Rivera, A. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00272 · Cited by 81
“IA is also considered to be the main fungal infection found in cancer patients (Bodey et al., 1992; Wald et al., 1997; Kaiser et al., 1998; Lehrnbecher et al., 2010).”
Background
Effects of dietary supplementation with Pediococcus acidilactici MA18/5M, galactooligosaccharide and their synbiotic on growth, innate immunity and disease resistance of rockfish ( Sebastes schlegeli )
Rahimnejad, S., Guardiola, F. A., Leclercq, E., Esteban, M. Á., Castex, M., Sotoudeh, E., & Lee, S. (2017) · Aquaculture · doi:10.1016/j.aquaculture.2017.09.020 · Cited by 77
Oxidative stress and macrophages: driving forces behind exacerbations of asthma and chronic obstructive pulmonary disease?
de Groot, L. E. S., van der Veen, A., Martínez, F. O., Hamann, J., Lutter, R., & Melgert, B. N. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00456.2018 · Cited by 76
Noxic effects of polystyrene microparticles on murine macrophages and epithelial cells
Rudolph, J., Völkl, M., Jérôme, V., Scheibel, T., & Freitag, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-95073-9 · Cited by 78
Oxidized Low-Density Lipoprotein Stimulates Macrophage 18F-FDG Uptake via Hypoxia-Inducible Factor-1α Activation Through Nox2-Dependent Reactive Oxygen Species Generation
Lee, S. J., Quach, C. H. T., Jung, K., Paik, J.-Y., Lee, J. H., Park, J. W., & Lee, K.-H. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.114.139428 · Cited by 81
“Inflammatory macrophages are a major source of ROS found in atherosclerotic plaques, which acts as a second messenger of inflammatory response (30).”
Background
Cutting Edge: Apoptosis-Regulating Signal Kinase 1 Is Required for Reactive Oxygen Species-Mediated Activation of IFN Regulatory Factor 3 by Lipopolysaccharide
Chiang, E., Dang, O., Anderson, K. R., Matsuzawa, A., Ichijo, H., & David, M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.10.5720 · Cited by 76
“ROS also received attention as intracellular signaling intermediates due to their ability to alter cytokine expression, modulate cellular proliferation, and induce apoptosis (16, 17).”
Background
Activation of the Silkworm Cytokine by Bacterial and Fungal Cell Wall Components via a Reactive Oxygen Species-triggered Mechanism
Ishii, K., Hamamoto, H., Kamimura, M., & Sekimizu, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705480200 · Cited by 75
VCAM-1 Signals Activate Endothelial Cell Protein Kinase Cα via Oxidation
Abdala‐Valencia, H., & Cook‐Mills, J. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.6379 · Cited by 73
Increased production of IL-1α and TNF-α in lipopolysaccharide-stimulated blood from obese patients with non-alcoholic fatty liver disease
Poníachik, J., Csendes, A., Díaz, J. C., Flores, J. R., Patricio Burdiles, P., Maluenda, F., Smok, G., Rodrigo, R., & Videla, L. A. (2006) · Cytokine · doi:10.1016/j.cyto.2006.02.006 · Cited by 73
Retrotaxis of human neutrophils during mechanical confinement inside microfluidic channels
Hamza, B. M., Wong, E. A., Patel, S. H., Cho, H., Martel, J., & Irimia, D. (2013) · Integrative Biology · doi:10.1039/c3ib40175h · Cited by 73
Oxidation of phenothiazine based fluorescent probe for hypochlorite and its application to live cell imaging
Vedamalai, M., Kedaria, D., Vasita, R., & Gupta, I. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.02.071 · Cited by 73
Antioxidant response of the seagrass Posidonia oceanica when epiphytized by the invasive macroalgae Lophocladia lallemandii
Sureda, A., Box, A., Terrados, J., Deudero, S., & Pons, A. (2008) · Marine Environmental Research · doi:10.1016/j.marenvres.2008.05.009 · Cited by 71
“H2O2 has also been known to act as cellular messenger for the induction of the antioxidant defence system in response to oxidative stress (Forman and Torres, 2002).”
Background
Coral cell separation and isolation by fluorescence-activated cell sorting (FACS)
Rosental, B., Kozhekbaeva, Z. M., Fernhoff, N. B., Tsai, J. M., & Traylor‐Knowles, N. (2017) · BMC Cell Biology · doi:10.1186/s12860-017-0146-8 · Cited by 71
“Take My Bone Away?” Hypoxia and bone: A narrative review
Hannah, S. S., McFadden, S. L., McNeilly, A., & McClean, C. M. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29921 · Cited by 76
VCAM-1 Activation of Endothelial Cell Protein Tyrosine Phosphatase 1B
Deem, T. L., Abdala‐Valencia, H., & Cook‐Mills, J. M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3865 · Cited by 71
“In contrast to the ROS-dependent indirect activation of the tyrosine phosphatase PTP1B in endothelial cells reported here, tyrosine phosphatases can be directly inhibited by ROS through oxidation of the cysteine in their catalytic domain (16, 17).”
Background
Role of NADPH Oxidase in Formation and Function of Multinucleated Giant Cells
Quinn, M. T., & Schepetkin, I. A. (2009) · Journal of Innate Immunity · doi:10.1159/000228158 · Cited by 72
“]. Thus, it is difficult to explain the mechanisms behind the RANKL-independent systems that have been reported. One suggestion is that these inflammatory signals obviate the need for RANK by directly activating the NF-κB pathway, which would lead to multinucleation when the right combination of additional signals is…”
Background
Stimulation of the alveolar macrophage respiratory burst by ADP causes selective glutathionylation of protein tyrosine phosphatase 1B
Rinna, A., Torrès, M., & Forman, H. J. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.03.010 · Cited by 72
“While the mechanisms through which H2O2 regulates pathways and responses are still uncertain in many cases [5, 7-11], “glutathionylation” of signaling proteins, which is one of the posttranslational modifications that occurs in cells in response to environmental or endogenous stimulation, has been implicated in cell s…”
BackgroundSelf-citation
In vitro immune toxicity of polybrominated diphenyl ethers on murine peritoneal macrophages: Apoptosis and immune cell dysfunction
Lv, Q., Wan, B., Guo, L., Zhao, L., & Yang, Y. (2014) · Chemosphere · doi:10.1016/j.chemosphere.2014.08.029 · Cited by 71
“Alternatively, ROS signaling, particularly through NF-jB, might play a critical role in the transcription and translation of NF-jB target genes, including various cytokines and chemokines that recruit and stimulate macrophages (Forman and Torres, 2002; Vernon and Tang, 2013).”
Background
Regulation of Toll-like Receptor-Mediated Sestrin2 Induction by AP-1, Nrf2, and the Ubiquitin-Proteasome System in Macrophages
Kim, M. G., Yang, J. H., Kim, K. M., Jang, C. H., Jung, J. Y., Cho, I. J., Shin, S. M., & Ki, S. H. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv012 · Cited by 70
Thyroid hormone-induced oxidative stress in rodents and humans: A comparative view and relation to redox regulation of gene expression
Fernández, V., Tapia, G., Varela, P., Pamela Romanque, U., Cartier-Ugarte, D., & Videla, L. A. (2005) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2005.10.007 · Cited by 69
“Cell signaling is primarily exerted at the Kupffer cell level, which is the most important source of TNFa, produced and released in response to several stimuli including ROS derived from activated NADPH oxidase (Forman and Torres, 2002).”
Background
Supplementation with gliadin‐combined plant superoxide dismutase extract promotes antioxidant defences and protects against oxidative stress
Vouldoukis, I., Conti, M., Krauss, P., Kamaté, C., Blazquez, S., Tefit, M., Mazier, D., Calenda, A., & Dugas, B. (2004) · Phytotherapy Research · doi:10.1002/ptr.1542 · Cited by 68
“It also produces reactive oxygen species involved in the regulation of many different biological processes (Forman and Torres, 2002) and survival from invading pathogens.”
Background
The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria
Billings, E. A., Lee, C. S., Owen, K. A., D’Souza, R. S., Ravichandran, K. S., & Casanova, J. E. (2016) · Science Signaling · doi:10.1126/scisignal.aac6250 · Cited by 69
Approach To Deliver Two Antioxidant Enzymes with Mesoporous Silica Nanoparticles into Cells
Lin, Y.-H., Chen, Y., Liu, T., Chien, F., Chou, C., Chen, C.-T., & Mou, C. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b05834 · Cited by 68
Effects of dietary synbiotic on innate immunity, antioxidant activity and disease resistance of Cirrhinus mrigala juveniles
Kumar, P., Jain, K. K., & Sardar, P. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.05.045 · Cited by 68
The Role of Hydrogen Peroxide and Other Reactive Oxygen Species in Wound Healing
Kanta, J. (2011) · Acta Medica (Hradec Kralove Czech Republic) · doi:10.14712/18059694.2016.28 · Cited by 68
“The ability of macrophages to produce ROS is much smaller than that of neutrophils but ROS and particularly H2O2 are important second messengers regulating physiological functions of macrophages (12).”
Background
NOX enzymes: potential target for the treatment of acute lung injury
Carnésecchi, S., Pache, J., & Barazzone‐Argiroffo, C. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1013-6 · Cited by 67
“In addition, ROS participates in the modulation of cell-signaling pathways that activate transcription factor of redox-sensitive pro-inflammatory mediators such as NF-jB [71, 72].”
BackgroundInfluential
The potential of hyperbaric oxygen as a therapy for neurodegenerative diseases
Mensah-Kane, P., & Sumien, N. (2022) · GeroScience · doi:10.1007/s11357-022-00707-z · Cited by 65
Modulation of Experimental Herpes Encephalitis-Associated Neurotoxicity through Sulforaphane Treatment
Schachtele, S. J., Hu, S., & Lokensgard, J. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036216 · Cited by 65
“production [24], therefore we quantified intracellular ROS in CD11b, CD45 cells using DCFH-DA (Figure 7B).”
Method
Exposure to hydrogen peroxide diminishes NF-κB activation, IκB-α degradation, and proteasome activity in neutrophils
Żmijewski, J. W., Zhao, X., Xu, Z., & Abraham, E. H. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00618.2006 · Cited by 64
“Because H2O2 can reversibly modify intracellular targets, it is capable of modulating signaling events and cellular activation in much the same manner as traditional second messengers (19, 20, 47).”
Background
Enhanced survival effect of pyruvate correlates MAPK and NF-κB activation in hydrogen peroxide-treated human endothelial cells
Lee, Y., Kang, I., Bünger, R., & Kang, Y. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00797.2003 · Cited by 65
“On the other hand, there is growing evidence that ROS may cause cell death via a mediation of mitogen-activated protein kinase (MAPK) under various pathological conditions (7, 9, 10, 47).”
Background
Lipid peroxidation increases hydrogen peroxide permeability leading to cell death in cancer cell lines that lack mtDNA
Tomita, K., Takashi, Y., Ouchi, Y., Kuwahara, Y., Igarashi, K., Nagasawa, T., Nabika, H., Kurimasa, A., Fukumoto, M., Nishitani, Y., et al. (2019) · Cancer Science · doi:10.1111/cas.14132 · Cited by 66
Transcriptional and Epigenetic Regulation of Monocyte and Macrophage Dysfunction by Chronic Alcohol Consumption
Malherbe, D. C., & Messaoudi, I. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.911951 · Cited by 67
Platycodin D protects against cigarette smoke-induced lung inflammation in mice
Gao, W., Guo, Y., & Yang, H. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.03.009 · Cited by 66
Bioconjugates of cyclodextrins of manganese salen-type ligand with superoxide dismutase activity
Puglisi, A., Tabbı̀, G., & Vecchio, G. (2004) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.02.012 · Cited by 62
Overview of oxidative stress and the role of micronutrients in critical illness
Dresen, E., Pimiento, J. M., Patel, J. J., Heyland, D. K., Rice, T. W., & Stoppe, C. (2022) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2421 · Cited by 71
Proteomic analysis of protein carbonylation: a useful tool to unravel nanoparticle toxicity mechanisms
Drießen, M. D., Mues, S., Vennemann, A., Hellack, B., Bannuscher, A., Vimalakanthan, V., Riebeling, C., Ossig, R., Wiemann, M., Schnekenburger, J., et al. (2015) · Particle and Fibre Toxicology · doi:10.1186/s12989-015-0108-2 · Cited by 61
“Moreover, it has been demonstrated that NPs may elicit a respiratory burst in professional phagocytes such as macrophages [14, 15], which use a NADPH-oxidase dependent defense mechanism primarily against viruses or bacteria together with expression of cytokines [12, 13].”
Background
Enzyme Inhibition and Bioapplications
Sharma, R. (2012) · InTech eBooks · doi:10.5772/1963 · Cited by 59
Biodegradable microspheres alone do not stimulate murine macrophages in vitro, but prolong antigen presentation by macrophages in vitro and stimulate a solid immune response in mice
Luzardo-Alvarez, A., Blarer, N., Peter, K., Romero, J. F., Reymond, C., Corradin, G., & Gander, B. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.09.015 · Cited by 59
Therapeutic targeting of microglia mediated oxidative stress after neurotrauma
Smith, A. N., Shaughness, M., Collier, S., Hopkins, D., & Byrnes, K. R. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.1034692 · Cited by 63
Extracellular ATP‐stimulated macrophages produce macrophage inflammatory protein‐2 which is important for neutrophil migration
Kawamura, H., Kawamura, T., Kanda, Y., Kobayashi, T., & Abo, T. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03601.x · Cited by 60
Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer
Penney, R. B., & Roy, D. (2013) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.02.005 · Cited by 62
Glutathione attenuates ethanol-induced alveolar macrophage oxidative stress and dysfunction by downregulating NADPH oxidases
Yeligar, S. M., Harris, F. L., Hart, C. M., & Brown, L. A. S. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00159.2013 · Cited by 59
“Under physiological conditions, the primary sources of ROS production are the Noxes (28, 57).”
Background
Microglial NADPH oxidase activation mediates rod cell death in the retinal degeneration in rd mice
Zeng, H., Ding, M., Chen, X.-X., & Lu, Q. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.065 · Cited by 64
Protein Thiol Redox Signaling in Monocytes and Macrophages
Short, J. D., Downs, K. P., Tavakoli, S., & Asmis, R. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6697 · Cited by 58
“To date, seven Nox family members (Nox 1–5 and Duox 1–2) have been characterized and found to differ in their tissue distribution (21), with four of these family members (NOX1, NOX2, NOX3, and NOX4) reported to be expressed in monocytes or macrophages (21, 62, 115, 174).”
Background
Cross‐Talk between Oxidative Stress and m6A RNA Methylation in Cancer
Yang, B., & Chen, Q. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6545728 · Cited by 61
Protective effect of polysaccharides from Sargassum horneri against oxidative stress in RAW264.7 cells
Wen, Z., Liu, L.-J., Ouyang, X., Qu, Y., Chen, Y., & Ding, G. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.04.037 · Cited by 59
Cytosolic NADP+-dependent isocitrate dehydrogenase protects macrophages from LPS-induced nitric oxide and reactive oxygen species
Maeng, O., Kim, Y. C., Shin, H.-J., Lee, J., Huh, T., Kang, K.-I., Kim, Y. S., Paik, S., & Lee, H. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.03.075 · Cited by 59
Role of catalase in monocytic differentiation of U937 cells by TPA: hydrogen peroxide as a second messenger
Yamamoto, T., Sakaguchi, N., Hachiya, M., Nakayama, F., Yamakawa, M., & Akashi, M. (2008) · Leukemia · doi:10.1038/leu.2008.353 · Cited by 59
Protein oxidation: role in signalling and detection by mass spectrometry
Spickett, C. M., & Pitt, A. R. (2012) · Amino Acids · doi:10.1007/s00726-010-0585-4 · Cited by 65
“The literature on proteins redoxregulated by oxidation of cysteine residues is growing rapidly, along with our understanding of the molecular mechanisms involved in reversible thiol oxidation (Forman and Torres 2002; Janssen-Heininger et al. 2008; Rhee et al. 2005; Spickett et al. 2006; Winterbourn and Hampton 2008).”
Background
Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction
Garcia, R. A., Lupisella, J. A., Ito, B. R., Hsu, M.-Y., Fernando, G., Carson, N. L., Allocco, J., Ryan, C. S., Zhang, R., Wang, Z., et al. (2021) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2021.07.007 · Cited by 58
“A similar response was observed with zymosan-induced oxidative burst activity, a known response that occurs in activated macrophages following phagosome ingestion (29).”
Background
Effect of titanium dioxide on the oxidative metabolism of alveolar macrophages: An experimental study in rats
Olmedo, D. G., Tasat, D. R., Guglielmotti, M. B., & Cabrini, R. L. (2005) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30230 · Cited by 58
“” A known and distinctive feature of phagocytes is their ability to respond to appropriate stimuli by activation of a respiratory burst.(38,39) The respiratory burst involves the increased production of reactive oxygen species (ROS), mainly the superoxide anion, from the reduction of oxygen by NADPH oxidase.”
Background
Targeting CSCs in Tumor Microenvironment: The Potential Role of ROS-Associated miRNAs in Tumor Aggressiveness
Bao, B., Azmi, A. S., Li, Y., Ahmad, A., Ali, S. S., Banerjee, S., Kong, D., & Sarkar, F. H. (2013) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x113089990053 · Cited by 60
“Such oxidation of bio-molecules might be reversible in the presence of endogenous anti-oxidants in the body [11].”
Background
The Evolution and Regulation of the Mucosal Immune Complexity in the Basal Chordate Amphioxus
Huang, S., Wang, X., Yan, Q., Guo, L., Yuan, S., Huang, G., Huang, H., Li, J., Dong, M., Chen, S., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001824 · Cited by 58
“Oxidative burst occurs in the activated mammalian phagocytes, which rapidly release a large amount of reactive oxygen species (ROS) into the phagosome to kill ingested bacteria (36).”
Background
Molecular mechanisms of immunomodulatory activity by polysaccharide isolated from the peels of Citrus unshiu
Shin, M., Park, S. B., & Shin, K. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.02.006 · Cited by 58
Eco-Friendly Green Synthesis and Characterization of Silver Nanoparticles by Scutellaria multicaulis Leaf Extract and Its Biological Activities
Gharari, Z., Hanachi, P., Sadeghinia, H., & Walker, T. R. (2023) · Pharmaceuticals · doi:10.3390/ph16070992 · Cited by 59
Viability of Human Blood Leukocytes Compared with Their Respective Cell Lines after Plasma Treatment
Bundscherer, L., Bekeschus, S., Tresp, H., Hasse, S., Reuter, S., Weltmann, K., Lindequist, U., & Masur, K. (2013) · Plasma Medicine · doi:10.1615/plasmamed.2013008538 · Cited by 57
Survival of monocytes and macrophages and their role in health and disease
Hunter, M. G. (2009) · Frontiers in bioscience · doi:10.2741/3514 · Cited by 58
“We demonstrated that human monocytes produce ROS after M-CSF stimulation and these endogenous ROS play important roles in monocyte survival (46,47).”
Background
Oxidative stress in the lung tissue--sources of reactive oxygen species and antioxidant defence.
Tkaczyk, J., & Vízek, M. (2007) · PubMed · Cited by 57
Microarray analysis of activated mixed glial (microglia) and monocyte-derived macrophage gene expression
Albright, A. V., & González‐Scarano, F. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.09.007 · Cited by 57
New bioinformatics approach to analyze gene expressions and signaling pathways reveals unique purine gene dysregulation profiles that distinguish between CD and UC
Rybaczyk, L. A., Rozmiarek, A., Circle, K. C., Grants, I. S., NEEDLEMAN, B. J., Wunderlich, J. E., Huang, K., & Christofi, F. L. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20893 · Cited by 56
OxInflammation in Rett syndrome
Pecorelli, A., Cervellati, C., Hayek, J., & Valacchi, G. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.07.015 · Cited by 59
“…be generated by reactions catalyzed by free transition metals, leaks from lipoxygenases, cyclooxygenases, xanthine oxidase and phagocytic and non-phagocytic nicotinamide adenine dinucleotide phosphate oxidases (Noxs) etc (Sies 2015; Forman and Torres 2002; Bergamini et al. 2004; Valko et al. 2005).”
Background
ROS-triggered degradation of selenide-containing polymers based on selenoxide elimination
Wang, L., Zhu, K., Cao, W., Sun, C., Lu, C., & Xu, H. (2019) · Polymer Chemistry · doi:10.1039/c9py00171a · Cited by 57
Macrophage Bactericidal Activities against Staphylococcus aureus Are Enhanced In Vivo by Selenium Supplementation in a Dose-Dependent Manner
Aribi, M., Meziane, W., Habi, S., Boulatika, Y., Marchandin, H., & Aymeric, J. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135515 · Cited by 55
“Hydrogen peroxide (H2O2) is one of the most active oxygen species, which is produced in the mitochondria by MnSOD (manganese-containing superoxide dismutase, SOD2) as an end product of plasma membrane associated-reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase during the respiratory burst in activat…”
Background
The Immunophysiology of Male Reproduction
Hedger, M. P. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00019-3 · Cited by 61
“121, 631 The most important ROS are the superoxide anion (O 2 − ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (HO%), nitric oxide (NO%), and peroxynitrite anion (ONOO − ) (Figure 19 .13).”
Background
Accumulation of CD11c+CD163+ Adipose Tissue Macrophages through Upregulation of Intracellular 11β-HSD1 in Human Obesity
Nakajima, S., Koh, V., Kua, L., So, J. B. Y., Lomanto, D., Lim, K., Petersen, S. H., Yong, W. P., Shabbir, A., & Kono, K. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600895 · Cited by 56
“Activated monocytes/macrophages produce ROS that can affect their microenvironment (30, 31).”
Background
Exercise and Glycemic Control: Focus on Redox Homeostasis and Redox-Sensitive Protein Signaling
Parker, L., Shaw, C. S., Stepto, N. K., & Levinger, I. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00087 · Cited by 55
“…of catecholamine (102), lactate accumulation (103, 104), elevated core body temperature (105), hemoglobin and myoglobin-mediated autooxidation (106–108), and postexercise inflammatory and phagocytic responses including ischemic reperfusion, cytokine secretion, and respiratory burst (109–111).”
Redox Regulation of Lipopolysaccharide-mediated Sulfiredoxin Induction, Which Depends on Both AP-1 and Nrf2
Kim, H., Jung, Y., Shin, B. S., Kim, H., Song, H., Bae, S. H., Rhee, S. G., & Jeong, W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.126839 · Cited by 56
Glucose 6-phosphate dehydrogenase and the kidney
Spencer, N. Y., & Stanton, R. C. (2016) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000294 · Cited by 54
Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-κB, and cytokine expression
Strassheim, D., Asehnoune, K., Park, J., Kim, J. Y., He, Q., Richter, D., Mitra, S., Arcaroli, J. J., Kuhn, K., & Abraham, E. H. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00296.2003 · Cited by 54
“In particular, intracellular concentrations of H2O2 increase through pathways involving cellular activation by PDGF, EGF, bFGF, GM-CSF, TGF- 1, IL-1, IL-3, and TNF- (18, 47).”
BackgroundInfluential
Paraoxonase 2 decreases renal reactive oxygen species production, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of NADPH oxidase
Yang, Y., Zhang, Y., Cuevas, S., Villar, V. A. M., Escano, C. S., Asico, L. D., Yu, P., Grandy, D. K., Felder, R. A., Armando, I., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.015 · Cited by 53
Anti-oxidant inhibition of hyaluronan fragment-induced inflammatory gene expression
Eberlein, M. H., Scheibner, K. A., Black, K. E., Collins, S. L., Chan‐Li, Y., Powell, J. D., & Horton, M. R. (2008) · Journal of Inflammation · doi:10.1186/1476-9255-5-20 · Cited by 56
“ROS have been identified as second messengers in cells, and play a role in receptor signaling and posttranslational modification of signaling molecule activity [41,42].”
Background
Review—Quantification of Hydrogen Peroxide by Electrochemical Methods and Electron Spin Resonance Spectroscopy
Gulaboski, R., Mirčeski, V., Kappl, R., Hoth, M., & Bozem, M. (2019) · Journal of The Electrochemical Society · doi:10.1149/2.1061908jes · Cited by 53
Inflammation and (secondary) genotoxicity of Ni and NiO nanoparticles
Åkerlund, E., Islam, M. S., McCarrick, S., Alfaro‐Moreno, E., & Karlsson, H. L. (2019) · Nanotoxicology · doi:10.1080/17435390.2019.1640908 · Cited by 53
“The exact mechanism for the secondary genotoxicity is currently not known and future studies exploring this using e.g. ROS scavengers, chelators, iNOS, as well as NADPD oxidase inhibitors and inhibitors of cell uptake would be valuable.”
BackgroundInfluential
Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment
Garcia, R. A., Ito, B. R., Lupisella, J. A., Carson, N., Hsu, M.-Y., Fernando, G., Héroux, M., Bouvier, M., Dierks, E. A., Kick, E. K., et al. (2019) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2019.07.005 · Cited by 53
“Activated phagocytes release reactive oxygen species (oxidative burst) into the ingested phagosome (19).”
Background
Bilirubin nanomedicine ameliorates the progression of experimental autoimmune encephalomyelitis by modulating dendritic cells
Kim, T. W., Kim, Y., Jung, W., Kim, D. E., Keum, H., Son, Y., & Jon, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.01.019 · Cited by 53
Redox‐regulation of Erk1/2‐directed phosphatase by reactive oxygen species: Role in signaling TPA‐induced growth arrest in ML‐1 cells
Traore, K., Sharma, R. B., Thimmulappa, R. K., Watson, W. H., Biswal, S. S., & Trush, M. A. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21403 · Cited by 53
“O :2 is generated when a single electron prematurely leaves the METC and partially reduces molecular oxygen.”
BackgroundInfluential
Stimulatory TSH-Receptor Antibodies and Oxidative Stress in Graves Disease
Diana, T., Daiber, A., Oelze, M. W., Neumann, S., Olivo, P. D., Kanitz, M., Stamm, P., & Kahaly, G. J. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00509 · Cited by 54
Live cell imaging of signaling and metabolic activities
Depaoli, M. R., Bischof, H., Eroğlu, E., Burgstaller, S., Ramadani‐Muja, J., Rauter, T., Schinagl, M., Waldeck‐Weiermair, M., Hay, J., Graier, W. F., et al. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.06.003 · Cited by 53
NADPH oxidase-derived reactive oxygen species are responsible for the high susceptibility to arsenic cytotoxicity in acute promyelocytic leukemia cells
Wang, J., Li, L., Cang, H., Shi, G., & Yi, J. (2007) · Leukemia Research · doi:10.1016/j.leukres.2007.06.006 · Cited by 52
Pharmaconutrition Review: Physiological Mechanisms
Pierre, J. F., Heneghan, A. F., Lawson, C. M., Wischmeyer, P. E., Kozar, R. A., & Kudsk, K. A. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113493326 · Cited by 51
NAMPT-Mediated Salvage Synthesis of NAD+ Controls Morphofunctional Changes of Macrophages
Venter, G., Oerlemans, F. T. J. J., Willemse, M. P., Wijers, M., Fransen, J. A. M., & Wieringa, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097378 · Cited by 51
“Intracellularly, the ROS is involved in redox signaling, mediating the production of cytokines via NFkb-dependent mechanisms [83] but also regulating the activity of cofilin [84] which increases the recycling of actin monomers at the pointed end of actin filaments.”
Background
Redox‐regulation of activator protein 1 family members in blood cancer cell lines exposed to cold physical plasma‐treated medium
Schmidt, A., Rödder, K., Hasse, S., Masur, K., Toups, L., Lillig, C. H., von Woedtke, T., Wende, K., & Bekeschus, S. (2016) · Plasma Processes and Polymers · doi:10.1002/ppap.201600090 · Cited by 50
Antioxidant, Anti‐Inflammatory, and Analgesic Activities ofAgrimonia eupatoriaL. Infusion
Santos, T. N., Costa, G., Ferreira, J. P. S., Liberal, J. M. T., Francisco, V., Paranhos, A., Cruz, M. T., Castelo-Branco, M. S., Figueiredo, I. V., & Batista, M. T. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/8309894 · Cited by 51
Arsenic trioxide induces apoptosis and the formation of reactive oxygen species in rat glioma cells
Sun, Y., Wang, C., Wang, L., Dai, Z., & Yang, K. (2018) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-018-0074-4 · Cited by 51
“In glioma cells treated with As2O3, one of the most likely mechanisms for triggering an antitumor effect is the induction of ROS [29, 30].”
Background
p53 signalling controls cell cycle arrest and caspase-independent apoptosis in macrophages infected with pathogenicLeptospiraspecies
Hu, W., Ge, Y., Ojcius, D. M., Sun, D. Y., Dong, H., Yang, X., & Yan, J. (2013) · Cellular Microbiology · doi:10.1111/cmi.12141 · Cited by 53
“During phagocytosis of microbial pathogens, phagocytes produce a high level of ROS to induce cellular oxidative stress and promoting the antimicrobial response (Forman and Torres, 2002; Lee et al., 2003).”
Background
Triptolide mitigates radiation-induced pulmonary fibrosis via inhibition of axis of alveolar macrophages-NOXes-ROS-myofibroblasts
Chen, C., Yang, S., Zhang, M., Zhang, Z., Hong, J., Han, D., Ma, J., Zhang, S. B., Okunieff, P. G., & Zhang, L. (2016) · Cancer Biology & Therapy · doi:10.1080/15384047.2016.1139229 · Cited by 51
“The enzymes responsible for ROS generation are NOXes.(21)”
Background
The Streptococcus pneumoniae yefM-yoeB and relBE Toxin-Antitoxin Operons Participate in Oxidative Stress and Biofilm Formation
Chan, W. T., Domenech, M., Moreno-Córdoba, I., Navarro-Martínez, V., Nieto, C., Moscoso, M., Garcı́a, E., & Espinosa, M. (2018) · Toxins · doi:10.3390/toxins10090378 · Cited by 50
Redox control of changes in protein sulfhydryl levels during human sperm capacitation
de Lamirande, E., & Gagnon, C. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00501-x · Cited by 50
Mimicking the host and its microenvironmentin vitrofor studying mucosal infections byPseudomonas aeruginosa
Crabbé, A., Ledesma, M. A., & Nickerson, C. A. (2014) · Pathogens and Disease · doi:10.1111/2049-632x.12180 · Cited by 49
“…of immune cells such as macrophages or neutrophils are relevant given their generation of reactive oxygen and nitrogen species, and cytokines, which affect P. aeruginosa viability and expression of clinically important virulence factors (Mathee et al., 1999; Forman & Torres, 2002; Wu et al., 2005).”
Decreasing CB1 receptor signaling in Kupffer cells improves insulin sensitivity in obese mice
Jourdan, T., Nicoloro, S. M. C., Zhou, Z., Shen, Y., Liu, J., Coffey, N. J., Çınar, R., Godlewski, G., Gao, B., Aouadi, M., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.08.011 · Cited by 51
Trichomonas vaginalis: Reactive oxygen species mediates caspase-3 dependent apoptosis of human neutrophils
Song, H.-O., Shin, M. H., Ahn, M., Min, D.-Y., Kim, Y.-S., & Ryu, J. (2007) · Experimental Parasitology · doi:10.1016/j.exppara.2007.06.010 · Cited by 48
Effects of vitamin E-diffused highly cross-linked UHMWPE particles on inflammation, apoptosis and immune response against S. aureus
Chen, W., Bichara, D. A., Suhardi, V. J., Sheng, P., & Muratoglu, O. K. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.07.028 · Cited by 48
The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6
Hossain, M. M., Weig, B., Reuhl, K. R., Gearing, M., Wu, L., & Richardson, J. R. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.07.005 · Cited by 48
“…following exposure to LPS and MPTP. Studies using neuron-glia cultures from NADPH oxidase-deficient mice reported that NADPH oxidase initiates an intracellular ROS signaling pathways that can activate microglia and release inflammatory cytokines (Forman and Torres, 2002; Qin et al., 2004).”
Background
Hydrogen peroxide inhibits IL-12 p40 induction in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein
Khan, N., Rahim, S. S., Boddupalli, C. S., Ghousunnissa, S., Padma, S., Pathak, N., Thiagarajan, D., Hasnain, S. E., & Mukhopadhyay, S. (2005) · Blood · doi:10.1182/blood-2005-04-1707 · Cited by 48

Authors: Forman, H. J., & Torres, M.
Affiliations: University of Southern California (US)
Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Pediatrics, Children's Hospital Los Angeles Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, California
ORCID: Forman, Henry Jay
Venue: American Journal of Respiratory and Critical Care Medicine
Publisher: Oxford University Press (OUP)
Published: 2002-12
Volume: 166
Issue: Supplement_1
Pages: S4-S8
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/rccm.2206007
OpenAlex: W1874751834
Cited by: 891
References: 67
Citations by year: 2026: 18 · 2025: 21 · 2024: 23 · 2023: 32 · 2022: 47 · 2021: 44 · 2020: 36 · 2019: 31 · 2018: 44 · 2017: 43 · 2016: 50 · 2015: 43 · 2014: 48 · 2013: 45 · 2012: 44
FWCI: 2.28
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL037556, HL 37556)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: reactive oxygen species, NADPH oxidase, respiratory burst, macrophages, signal transduction, hydrogen peroxide, superoxide, antioxidant enzymes, thioredoxin reductase, thioredoxin, redox signaling, phagocytes
MeSH terms: Humans, Hydrogen Peroxide, Macrophages, Oxidation-Reduction, Signal Transduction, Respiratory Burst, Protein Tyrosine Phosphatases, Reactive Oxygen Species, Mitogen-Activated Protein Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Reactive Oxygen Species and Cell Signaling: Respiratory Burst in Macrophage Signaling

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks