The DOI matches its Crossref record; 66 of the 67 references it cites were found in a registry or an index.
Reactive Oxygen Species and Cell Signaling: Respiratory Burst in Macrophage Signaling
Abstract
Phagocytes such as neutrophils and macrophages produce reactive oxygen species (ROS) during phagocytosis or stimulation with a wide variety of agents through activation of nicotinamide adenine dinucleotide phosphate reduced (NADPH) oxidase that is assembled at the plasma membrane from resident plasma membrane and cytosolic protein components. One of the subunits of the phagocyte NADPH oxidase is now recognized as a member of a family of NADPH oxidases, or NOX, present in cells other than phagocytes. Physiologic generation of ROS has been implicated in a variety of physiologic responses from transcriptional activation to cell proliferation and apoptosis. The increase in superoxide and hydrogen peroxide (H2O2) that results from stimulation of the NADPH oxidase is transient, in part due to the presence of the antioxidant enzymes, which return their concentrations to the prestimulation steady state level. Thus, the antioxidant enzymes may function in the “turn-off” phase of signal transduction by ROS. During its transient elevation, H2O2 may act as a modifier of key signaling enzymes through reversible oxidation of critical thiols. The rapid reaction of thiols with H2O2 when in their unprotonated state would provide a potential mechanism for the specificity that is necessary for physiologic cell signaling.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The oxidative burst in phagocytes is commonly associated with bacterial killing, but in the case of alveolar macrophages, they typically produce lower levels of ROS than neutrophils and may require their activation to exhibit their bactericidal properties.”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [101]
In the citing paper
“Instead, their transient oxidative burst regulates the inflammatory response by inducing cytokine synthesis for redox signaling, resulting in an influx of activated neutrophils and macrophages [101].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [101]
Citations
Cites
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
Pearson, G. W., Robinson, F. L., Gibson, T. B., Xu, B.-E., Karandikar, M. S., Berman, K. S., & Cobb, M. H. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.2.0428 · Cited by 4,111
AP-1 as a regulator of cell life and death
Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961
Reactive oxygen species in cell signaling
Thannickal, V. J., & Fanburg, B. L. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.6.l1005 · Cited by 2,950
Babior, B. M., Kipnes, R. S., & Curnutte, J. T. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107236 · Cited by 2,931
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886
Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1
Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K., & Ichijo, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.9.2596 · Cited by 2,377
Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts
Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., & Goldschmidt-Clermont, P. J. (1997) · Science · doi:10.1126/science.275.5306.1649 · Cited by 1,588
Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro
Abate, C., Patel, L., Rauscher, F. J., & Curran, T. (1990) · Science · doi:10.1126/science.2118682 · Cited by 1,573
Flagged first, then by citations
1 of the 67 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- 2000, Mutat Res, 448, 179
- 2001, Endocr Rev, 22, 153
- 1996, J Biol Chem, 271, 4138, 10.1074/jbc.271.8.4138 · DOI
- 1996, Int J Pediatr Hematol Oncol, 3, 387
Cited by
Sorted by citations
Items 401–500 of 892
Collins, S., Pi, J., & Yehuda‐Shnaidman, E. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.08.002 · Cited by 33
“(4) Exaggerated and persistent oxidative stress that is unrelieved by antioxidants”
BackgroundLu, Q., Yang, Y., Villar, V. A. M., Asico, L. D., Jones, J. E., Yu, P., Li, H., Weinman, E. J., Eisner, G. M., & José, P. A. (2013) · Hypertension Research · doi:10.1038/hr.2013.9 · Cited by 31
Membrane-Tethered MUC1 Mucin Counter-Regulates the Phagocytic Activity of Macrophages
Kato, K., Uchino, R., Lillehoj, E. P., Knox, K. S., Lin, Y., & Kim, K. C. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2015-0177oc · Cited by 34
Khatua, S., & Acharya, K. (2017) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12813 · Cited by 31
von Knethen, A., Tautenhahn, A., Link, H., Lindemann, D., & Brüne, B. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4960 · Cited by 31
“The respiratory burst is an early activation marker in response to pathogen contact and constitutes a pivotal role in killing microorganisms (19).”
BackgroundLiu, Y., Zhang, J., Li, Y., Zhao, Y., Kuermanbayi, S., Zhuang, J., Zhang, H., Xu, F., & Li, F. (2023) · Chemical Science · doi:10.1039/d3sc03504b · Cited by 30
Plasma markers of oxidative stress are uncorrelated in a wild mammal
Christensen, L. L., Selman, C., Blount, J. D., Pilkington, J. G., Watt, K., Pemberton, J. M., Reid, J. M., & Nussey, D. H. (2015) · Ecology and Evolution · doi:10.1002/ece3.1771 · Cited by 30
Effect of Size, Shape, and Composition on the Interaction of Different Nanomaterials with HeLa Cells
Renero‐Lecuna, C., Iturrioz-Rodríguez, N., González‐Lavado, E., Padín-González, E., Navarro-Palomares, E., Valdivia-Fernández, L., García‐Hevia, L., Fanárraga, M. L., & González-Legarreta, L. (2019) · Journal of Nanomaterials · doi:10.1155/2019/7518482 · Cited by 30
Hanna, D. H., & Saad, G. R. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258115 · Cited by 32
Sun, Y., Kinsela, A. S., & Waite, T. D. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153727 · Cited by 30
Skibiel, A. L., Koh, J., Zhu, N., Zhu, F., Yoo, M., & Laporta, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-10461-z · Cited by 30
Ponte, C. B., Alves, É. A. R., Sampaio, R. N. R., Urdapilleta, A. A. A., Kückelhaus, C. D. S., Muniz‐Junqueira, M. I., & Kückelhaus, S. A. S. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.03.016 · Cited by 30
Sokolovic, D. T., Nikolić, J., Kocic, G. M., Jevtović−Stoimenov, T., Veljković, A., Stojanovic, M. P., Stanojković, Z., Sokolović, D., & Jelic, M. (2012) · Drug and Chemical Toxicology · doi:10.3109/01480545.2012.658919 · Cited by 30
Influence of ROS on Ovarian Functions
Ciani, F., Cocchia, N., d’Angelo, D., & Tafuri, S. (2015) · InTech eBooks · doi:10.5772/61003 · Cited by 30
“Many studies have demonstrated involvement of ROS in the follicular-fluid environment, folliculo‐ genesis, and steroidogenesis [74].”
BackgroundAn Introduction to Reactive Oxygen Species
Synergy, H., & Neo, S. (2015) · Cited by 30
Lipid Peroxidation: A Possible Marker for Diabetes
Vig, R. A. A. P. (2012) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.s11-007 · Cited by 30
“These are known to be highly lethal for the micro-organisms and are found to cause damage to the microbial nucleotides, redox enzymes, proteins and the most important among all damage is the genetic mutation observed after the action of phagocytes [28,30-32].”
BackgroundThe role of monocytes/macrophages in Leishmania infection: A glance at the human response
Loría‐Cervera, E. N., & Andrade-Narvaez, F. J. (2020) · Acta Tropica · doi:10.1016/j.actatropica.2020.105456 · Cited by 30
Asthma, Airway Biology, and Nasal Disorders in AJRCCM 2001
Tobin, M. J. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.5.2201062 · Cited by 30
Duan, J., Wei, G., Guo, C., Cui, J., Yan, J., Yin, Y., Guan, Y., Weng, Y., Zhu, Y., Wu, X., et al. (2015) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x15500664 · Cited by 29
“ROS are produced in aerobic cells during mitochondrial electron transport or by several oxidoreductases and metal-catalyzed oxidation of metabolites (Forman and Torres, 2002).”
BackgroundMechanistic Investigation on ROS Resistance of Phosphorothioated DNA
Wu, T., Huang, Q., Wang, X., Shi, T., Bai, L., Liang, J., Wang, Z., Deng, Z., & Zhao, Y. (2017) · Scientific Reports · doi:10.1038/srep42823 · Cited by 29
Alkan, H., Ciğerci, İ., Ali, M., Hazman, O., Liman, R., Colă, F., & Bonciu, E. (2022) · Plants · doi:10.3390/plants11101293 · Cited by 29
“A variety of these anti-oxidant functions are dependent on the pods, flowers and leaves of seedlings [44].”
BackgroundA guide to nanosafety testing: Considerations on cytotoxicity testing in different cell models
Riebeling, C., Piret, J., Trouiller, B., Nelissen, I., Saout, C., Toussaint, O., & Haase, A. (2017) · NanoImpact · doi:10.1016/j.impact.2017.11.004 · Cited by 29
“macrophages, can elicit a so-called respiratory burst during which they release reactive oxygen species and cytokines into the surrounding tissue (Forman and Torres 2002).”
BackgroundNishio, K., Qiao, S., & Yamashita, H. (2005) · The Histochemical Journal · doi:10.1007/s10735-004-2915-x · Cited by 29
“The activated phagocytes or macrophages produce the primordal oxygen radical, superoxide (O2 )) which is produced by the NADPH-driven reduction of extracellular molecular oxygen catalyzed by NADPH oxidase complex as reviewed previously (Forman and Torres 2002, Sigal et al. 2003).”
BackgroundMethodThe Antioxidant Potential of Vitamins and Their Implication in Metabolic Abnormalities
Theodosis‐Nobelos, P., & Rekka, E. A. (2024) · Nutrients · doi:10.3390/nu16162740 · Cited by 31
“…to the site of lysis, leading to a “respiratory burst” (so called due to oxygen consumption carried out through NADPH oxidases), and this is the main element for the antibacterial capacity of phagocytes [21,22] and increased release and accumulation of free radicals at the site of injury [23,24].”
BackgroundImmune checkpoint molecules in neuroblastoma: A clinical perspective
Pathania, A. S., Prathipati, P., Murakonda, S. P., Murakonda, A. B., Srivastava, A., Avadhesh, A., Byrareddy, S. N., Coulter, D. W., Gupta, S. C., & Challagundla, K. B. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.06.013 · Cited by 28
Kelishadi, M. R., Ashtary‐Larky, D., Davoodi, S. H., Clark, C. C. T., & Asbaghi, O. (2022) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2022.127046 · Cited by 28
Hydrogen peroxide increases the phagocytic function of human neutrophils by calcium mobilisation
Bejarano, I., Terrón, M. P., Paredes, S. D., Barriga, C., Rodríguez, A. B., & Pariente, J. A. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-006-9301-9 · Cited by 28
Action of two phospholipases A2 purified from Bothrops alternatus snake venom on macrophages
Setúbal, S. D. S., Pontes, A. S., Furtado, J., Xavier, C. V., Silva, F. L., Kayano, A. M., Izidoro, L. F. M., Soares, A. M., Calderón, L. A., Stábeli, R. G., et al. (2013) · Biochemistry (Moscow) · doi:10.1134/s0006297913020089 · Cited by 28
The regulation of the oxidative phase of the pentose phosphate pathway: New answers to old problems
Barcia, R., & Ramos-Martı́nez, J. I. (2014) · IUBMB Life · doi:10.1002/iub.1329 · Cited by 28
“In certain specialized cells, such as granulocytes and macrophages, NADPH also causes generation of reactive oxygen species (ROS) within the defensive system named “respiratory burst” (3).”
BackgroundImpact of the FcγII-receptor on quartz uptake and inflammatory response by alveolar macrophages
Haberzettl, P., Schins, R. P. F., Höhr, D., Wilhelmi, V., Borm, P. J. A., & Albrecht, C. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00261.2007 · Cited by 27
Khatua, S., & Acharya, K. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00985 · Cited by 28
“Thus, increase in NO and ROS production by the innate immune cell can be used as a representation of macrophage activation state (Forman and Torres, 2002; Razali et al., 2014).”
BackgroundNon-Vital Polymorphonuclear Leukocytes Express Myeloperoxidase on their Surface
Flemmig, J., Leßig, J., Reibetanz, U., Dautel, P., & Arnhold, J. (2008) · Cellular Physiology and Biochemistry · doi:10.1159/000129387 · Cited by 28
Gillet, F., Cattoni, D. I., Petiot-Bécard, S., Delalande, F., Poignavent, V., Brizard, J., Bessin, Y., DORSSELAER, A. V., Declerck, N., Cianférani, S., et al. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.03.028 · Cited by 25
Ohira, H., Fujioka, Y., Katagiri, C., Yano, M., Mamoto, R., Aoyama-Ishikawa, M., Usami, M., & Ikeda, M. (2011) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.11-22 · Cited by 27
NOX2β: A Novel Splice Variant of NOX2 That Regulates NADPH Oxidase Activity in Macrophages
Harrison, C. B., Selemidis, S., Guida, E., King, P. T., Sobey, C. G., & Drummond, G. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048326 · Cited by 30
Fu, W., Pan, Y., Shi, Y., Chen, J., Gong, D., Li, Y., Hao, G., & Han, D. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2021.802737 · Cited by 27
Controllable Nitric Oxide‐Delivering Platforms for Biomedical Applications
Liu, S., Li, G., & Ma, D. (2022) · Advanced Therapeutics · doi:10.1002/adtp.202100227 · Cited by 28
Scheible, M., Nguyen, C. T., Luong, T. T., Lee, J. H., Chen, Y., Chang, C., Wittchen, M., Camacho, M. I., Tiner, B. L., Wu, C., et al. (2022) · mBio · doi:10.1128/mbio.03022-21 · Cited by 26
Macrophage A2A Adenosinergic Receptor Modulates Oxygen-Induced Augmentation of Murine Lung Injury
Aggarwal, N. R., D’Alessio, F. R., Eto, Y., Chau, E. P., Avalos, C. R., Waickman, A. T., Garibaldi, B. T., Mock, J. R., Files, D. C., Sidhaye, V. K., et al. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0351oc · Cited by 27
“The mechanisms by which oxygen alters ADORA2A signaling after LPS exposure remain unknown, but possibilities include the production of reactive oxygen species (41), direct binding to a cell surface receptor/coreceptor, or indirect interaction through HA/Toll-like receptor (TLR) signaling pathways (42–44).”
BackgroundAkifusa, S., Kamio, N., Shimazaki, Y., Yamaguchi, N., & Yamashita, Y. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.08.005 · Cited by 27
Weber, T. J., Smallwood, H. S., Kathmann, L. E., Markillie, L. M., Squier, T. C., & Thrall, B. D. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00527.2005 · Cited by 27
Albuszies, G., & ckner, U. B. B. (2003) · Intensive Care Medicine · doi:10.1007/s00134-003-1861-5 · Cited by 27
“This has repercussions on the expression and control of the immuno-inflammatory response by cytokines and other mediators [ 7 ].”
BackgroundOxidative Stress and Peroxisome Proliferator–Activated Receptors
Devchand, P. R., Ziouzenkova, O., & Plutzky, J. (2004) · Circulation Research · doi:10.1161/01.res.0000151331.69399.b2 · Cited by 29
Cold Atmospheric Plasma: An Emerging Immunomodulatory Therapy
Liu, H., Liang, X., Teng, M., Li, Z., Peng, Y., Wang, P., Hu, C., Cheng, H., & Liu, G. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202300399 · Cited by 26
Magalotti, S., Gustafson, T. P., Cao, Q., Abendschein, D. R., Pierce, R. A., Berezin, M. Y., & Akers, W. J. (2013) · Molecular Imaging and Biology · doi:10.1007/s11307-013-0614-2 · Cited by 26
“A fundamental component of macrophage physiology is the release of ROS via the “respiratory burst” [5, 7].”
Juergens, L. J., Tuleta, I., Stoeber, M., Racké, K., & Juergens, U. R. (2018) · Synergy · doi:10.1016/j.synres.2018.05.001 · Cited by 26
Feng, G., Su, L., Chen, S., Wang, T., Zhou, D., Yin, C., & Shoudong, G. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.08.008 · Cited by 26
Pathophysiology of enteropathogenic Escherichia coli during a host infection
Lee, J. B., Kim, S. K., & Yoon, J. W. (2022) · Journal of Veterinary Science · doi:10.4142/jvs.21160 · Cited by 33
“For example, harsh environments in macrophage such as iron sequestration, oxidative burst, and acidic pH in phagosome can trigger bacterial stringent response [110-112].”
BackgroundKim, K. A., Kim, J. Y., Lee, Y. A., Song, K.-J., Min, D., & Shin, M. H. (2011) · Microbes and Infection · doi:10.1016/j.micinf.2011.06.001 · Cited by 26
Ooi, L., Heng, L. Y., & Mori, I. C. (2015) · Sensors · doi:10.3390/s150202354 · Cited by 27
The Release of Nitric Oxide from S-Nitrosothiols Promotes Angiogenesis
Al‐Ani, B., Hewett, P. W., Ahmed, S., Cudmore, M., Fujisawa, T., Ahmad, S., & Ahmed, A. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000025 · Cited by 26
“Antioxidants protect the body against the damaging effects of free radicals that can overwhelm the endogenous antioxidant systems in pathologies such as atherosclerosis and hypertension, and promote endothelial cell apoptosis [16,33–36].”
BackgroundLopes, F. C. M., Calvo, T. R., Vilegas, W., & Carlos, I. Z. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.1726 · Cited by 26
Rio, R. V. M., Anderegg, M., & Graf, J. (2007) · Microbiology · doi:10.1099/mic.0.2006/003020-0 · Cited by 26
“... innate immune responses, the introduction of Gram-negative bacteria and their byproducts into leech wounds activates an inflammatory response involving the infiltration of macrophage-like cells (de Eguileor et al., 1999, 2000a, b). During phagocytosis or following stimulation with a wide variety of agents, macroph…”
BackgroundThe Biological Significance of Zinc in Inflammation and Aging
Bao, B., Ahmad, A., Azmi, A. S., Li, Y., Prasad, A. S., & Sarkar, F. H. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397803-5.00002-2 · Cited by 26
Wang, J., Zhou, Y., Wu, S., Huang, K., Thapa, S., Tao, L., Wang, J., Shen, Y., Wang, J., Xue, Y., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00496 · Cited by 25
“ROS can induce macrophages to release proinflammatory cytokines, and, in turn, these cytokines can activate macrophages to increase intracellular ROS (Forman and Torres, 2002; McNelis and Olefsky, 2014).”
BackgroundPlatelet-Rich Fibrin Can Neutralize Hydrogen Peroxide-Induced Cell Death in Gingival Fibroblasts
Kargarpour, Z., Nasirzade, J., Summa, F. D., Panahipour, L., Miron, R. J., & Gruber, R. (2020) · Antioxidants · doi:10.3390/antiox9060560 · Cited by 25
Liu, X., Xu, Y., Li, Y., Pan, Y., Zhao, S., & Hou, Y. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.61525 · Cited by 25
Antioxidant Activity and the Potential Mechanism of the Fruit From Ailanthus altissima Swingle
Mo, Y., Cheng, F., Yang, Z., Shang, X., Liang, J., Shang, R., Hao, B., Wang, X., Zhang, H., Wali, A., et al. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.784898 · Cited by 25
Chlamydialesand the innate immune response: friend or foe?
Rusconi, B. A., & Greub, G. (2010) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2010.00772.x · Cited by 25
“The pathways activated by ROS signaling are still poorly understood (reviewed in Forman & Torres, 2002).”
BackgroundDual-functional probes for sequential thiol and redox homeostasis sensing in live cells
Ma, T., Ding, H., Xu, H., Lv, Y., Liu, H., Wang, H., & Tian, Z. (2014) · The Analyst · doi:10.1039/c4an01441c · Cited by 25
Extracellular catalase activity protects cysteine cathepsins from inactivation by hydrogen peroxide
Hervé‐Grépinet, V., Veillard, F., Godat, E., Heuzé‐Vourc'h, N., Lecaille, F., & Lalmanach, G. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.03.007 · Cited by 25
“Present results confirm that, under our experimental conditions, H2O2 had no cytotoxic effects on differentiated THP-1 cells [35], whereas macrophages could go through apoptosis in the presence of harsher amounts [4].”
ResultŽivković, J. M., Najman, S. J., Vukelić, M., Stojanović, S., Aleksić, M. S., Stanisavljević, M. N., & Najdanović, J. G. (2014) · Archives of Biological Sciences · doi:10.2298/abs140915020z · Cited by 25
“They are known to release a variety of factors that affect bone, such as proinflammatory cytokines and reactive oxygen species (Christou et al., 1987; Forman and Torres, 2002; Kanczler et al., 2003; Schett, 2011).”
BackgroundKumar, S., Sun, X., Wiseman, D. A., Tian, J., Umapathy, N. S., Verin, A. D., & Black, S. M. (2008) · DNA and Cell Biology · doi:10.1089/dna.2008.0775 · Cited by 25
“H 2 O 2 is an injurious by-product of cellular metabolism, but it also participants in cell signaling and has been shown to be regulator of vascular tone (Forman and Torres, 2002; Suvorava et al. , 2005).”
Paeonol Attenuates H2O2 -Induced NF-κB-Associated Amyloid Precursor Protein Expression
Su, S.-Y., Cheng, C.-Y., Tsai, T., Hsiang, C., Ho, T., & Hsieh, C. (2010) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x1000855x · Cited by 25
Kim, S.-S., Kim, J.-H., Han, I., Ahn, M., & Ryu, J. (2016) · Korean Journal of Parasitology · doi:10.3347/kjp.2016.54.2.123 · Cited by 25
“[38].”
Christian, C., Raith, T., Vatsyayan, P., Vyskočil, V., & Matysik, F. (2018) · Electrochimica Acta · doi:10.1016/j.electacta.2018.05.115 · Cited by 25
Kim, H. W., Shin, M., Lee, S. J., Park, H., Jee, H. S., Yoon, T. J., & Shin, K. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.03.159 · Cited by 25
Qamar, A. Y., Fang, X., Bang, S., Kim, M. J., & Cho, J. (2020) · Cryobiology · doi:10.1016/j.cryobiol.2020.05.015 · Cited by 25
Song, R., Baker, T. L., Watters, J. J., & Kumar, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031852 · Cited by 25
“Phagocyte activation undergoes respiratory bursts, during which large amounts of ROS are generated as part of their defense mechanisms against pathogens [25,26].”
BackgroundRole of endoplasmic reticulum stress in impaired neonatal lung growth and bronchopulmonary dysplasia
Pritchard, K. A., Jing, X., Teng, M., Wells, C. W., Jia, S., Afolayan, A. J., Jarzembowski, J. A., Day, B. W., Naylor, S., Hessner, M. J., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269564 · Cited by 24
“Initially, the supplement oxygen may only cause lung endothelial cells to generate superoxide anion [50] and resident myeloid cells to generate toxic oxidants [51].”
Lutter, D., Ugocsai, P., Grandl, M., Orsó, E., Theis, F. J., Lang, E. W., & Schmitz, G. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-100 · Cited by 24
“Caspases, TP53, Nf κ B, ceramide) and survival [36-42].”
BackgroundWang, M., Wang, L., Yi, Q., Gai, Y., & Song, L. (2015) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2015.09.035 · Cited by 25
Antioxidative effect of phycoerythrin derived from Grateloupia filicina on rat primary astrocytes
Jung, S.-M., Park, J. S., Shim, H. J., Kwon, Y. S., Kim, H. G., & Shin, H. S. (2016) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-016-0369-0 · Cited by 24
“Superoxide anion, a progenitor of reactive oxygen species (ROS), gains an additional electron via enzymes such as xanthine oxidase and glucose oxidase, resulting in hydrogen peroxide (H2O2) [1-4].”
BackgroundRefsnes, M., Skuland, T., Lilleaas, E. M., Øvrevik, J., & Låg, M. (2019) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13221 · Cited by 24
Xie, J., Zhao, Q., Huang, H., Fang, Z., & Hu, Y. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.736382 · Cited by 24
Marcil, V., Lavoie, J., Emonnot, L., Seidman, E. G., & Levy, E. H. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.04.012 · Cited by 24
Enrichment of antioxidant peptide from rice protein hydrolysates via rice husk derived biochar
Tao, H.-Z., He, W., Ding, L., Li, W., Xu, Z., Cheng, Y., & Chen, M. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.141050 · Cited by 23
Premshekharan, G., Nguyen, K., Zhang, H., Forman, H. J., & Leppert, V. J. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.05.004 · Cited by 23
Self-citationNitrone-Trolox conjugate as an inhibitor of lipid oxidation: Towards synergistic antioxidant effects
Socrier, L., Rosselin, M., Giraldo, A. M. G., Chantemargue, B., Meo, F. D., Trouillas, P., Durand, G., & Morandat, S. (2019) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2019.06.008 · Cited by 23
Polarization of Macrophages in Insects: Opening Gates for Immuno-Metabolic Research
Bajgar, A., Krejčová, G., & Doležal, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.629238 · Cited by 22
“This can be explained by the massive utilization of oxygen for the generation of reactive oxygen and nitric species (ROS/RNS) later used for bacterial killing in phagolysosomes and oxidative burst (Forman and Torres, 2002).”
BackgroundHanna, D. H., Aziz, M. M., & Shafee, E. E. (2023) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2456 · Cited by 23
Wright, D. C., & Sutherland, L. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-155 · Cited by 23
“In addition to the mitochondrial generation of ROS, increases in the expression of pro-oxidant enzymes, such as NADPH oxidase, can lead to enhanced ROS production (Forman and Torres 2002).”
BackgroundSynthesis of Oxidant Prone Nanosilver To Develop H2O2 Responsive Drug Delivery System
Muhammad, F., Wang, A., Miao, L., Wang, P., Li, Q., Liu, J., Du, J., & Zhu, G. (2014) · Langmuir · doi:10.1021/la503922j · Cited by 23
SAEED, S. A., Connor, J. D., Imran, I., Quadri, J., Tasneem, S., Ahmed, S., Mesaik, M. A., & Choudhary, M. I. (2007) · PubMed · Cited by 23
Fukai, E., Sato, H., Watanabe, M., Nakae, D., & Totsuka, Y. (2018) · Cancer Science · doi:10.1111/cas.13534 · Cited by 23
“It has also been noted that IL-1b induces superoxide through the activation of NADPH oxidase on the endosomal membrane when macrophages incorporate exogenous materials.(21-24) Moreover, proinflammatory cytokines, such as IL-1b and TNF-a, could induce activation of nuclear factor (NF)-kB, a key transcription factor for…”
BackgroundSmallwood, H. S., Shi, L., & Squier, T. C. (2006) · Biochemistry · doi:10.1021/bi060485p · Cited by 23
Basu, S. K., Kumar, D., Singh, D. K., Ganguly, N., Siddiqui, Z., Rao, K. V. S., & Sharma, P. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05543.x · Cited by 24
Inflammatory response of a prostate stromal cell line induced by Trichomonas vaginalis
Im, S. J., Han, I., Kim, J. H., Gu, N. Y., Seo, M. Y., Chung, Y. H., & Ryu, J. S. (2016) · Parasite Immunology · doi:10.1111/pim.12308 · Cited by 23
Entamoeba histolytica Induces Cell Death of HT29 Colonic Epithelial Cells via NOX1-Derived ROS
Kim, K. A., Kim, J. Y., Lee, Y. A., Min, A., Bahk, Y. Y., & Shin, M. H. (2013) · Korean Journal of Parasitology · doi:10.3347/kjp.2013.51.1.61 · Cited by 22
“cellular receptor signal transduction pathways, and they play pivotal roles in various biological activities, including host defense, cell growth and differentiation, stimulation of pro-inflammatory genes, and cell death [12].”
BackgroundWang, J., Lu, D., Jiang, B., Mo, X., Du, J., & Li, A. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.734943 · Cited by 22
Oxidative stress and macrophage infiltration in IgA nephropathy
Çalışkan, Y., Demir, E., Karatay, E., Özlük, Y., Mirioğlu, Ş., Dirim, A. B., Artan, A. S., Akgül, S. U., Oto, Ö. A., Oğuz, F. S., et al. (2021) · Journal of Nephrology · doi:10.1007/s40620-021-01196-7 · Cited by 22
Cellular heterogeneity and plasticity during NAFLD progression
Park, H., Choi, J., Kim, H.-M., Yang, D.-Y., An, T. H., Lee, E., Han, B., Lee, S. C., Kim, W. K., Bae, K., et al. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1221669 · Cited by 22
“It helps kill microorganisms or stimulates redox-sensitive targets including protein kinase C, NF-κB, and ERK family members (Forman and Torres, 2002).”
BackgroundSuntres, Z. E., & Lui, E. M. K. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.04.007 · Cited by 22
Bui-Xuan, N.-H., Tang, P. M., Wong, C. K., Chan, J. Y., Cheung, K. K. Y., Jiang, J. L., & Fung, K. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2011.02.010 · Cited by 22
Zavřel, M., Majer, O., Kuchler, K., & Rupp, S. (2011) · Eukaryotic Cell · doi:10.1128/ec.05206-11 · Cited by 22
“The production of ROS by innate immune cells is part of the first line of defense against pathogens (6, 12).”
BackgroundGrazielle-Silva, V., Zeb, T. F., Bolderson, J., Campos, P. C., Miranda, J. B., Alves, C. L., Machado, C. R., McCulloch, R., & Teixeira, S. M. R. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003870 · Cited by 23
“Due to their phagocytic nature, macrophages naturally produce ROS through the activation of NADPH oxidase during phagocytosis or by stimulation with a wide range of infective agents [61].”
BackgroundResveratrol as promising natural radioprotector. A review.
Dobrzyńska, M. M. (2013) · PubMed · Cited by 22
Heat stress induces ROS production and histone phosphorylation in celomocytes of Eisenia hortensis
Tumminello, R. A., & Fuller-Espie, S. L. (2013) · Invertebrate survival journal · Cited by 22
Effect of Bromelain-Based Enzymatic Debridement on Skin Cells
Schulz, A., Fuchs, P. C., Opländer, C., Valdez, L. B., & Schiefer, J. L. (2018) · Journal of Burn Care & Research · doi:10.1093/jbcr/irx011 · Cited by 22
Vulnerability of glutathione-depleted Crassostrea gigas oysters to Vibrio species
Mello, D. F., Trevisan, R., Danielli, N. M., & Dafré, A. L. (2019) · Marine Environmental Research · doi:10.1016/j.marenvres.2019.104870 · Cited by 21
Metadata
- Authors
- Forman, H. J., & Torres, M.
- Affiliations
- University of Southern California (US)
- Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Pediatrics, Children's Hospital Los Angeles Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, California
- ORCID
- Forman, Henry Jay
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-12
- Volume
- 166
- Issue
- Supplement_1
- Pages
- S4-S8
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1874751834
- Cited by
- 891
- References
- 67
- Citations by year
- 2026: 18 · 2025: 21 · 2024: 23 · 2023: 32 · 2022: 47 · 2021: 44 · 2020: 36 · 2019: 31 · 2018: 44 · 2017: 43 · 2016: 50 · 2015: 43 · 2014: 48 · 2013: 45 · 2012: 44
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL037556, HL 37556)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- reactive oxygen species, NADPH oxidase, respiratory burst, macrophages, signal transduction, hydrogen peroxide, superoxide, antioxidant enzymes, thioredoxin reductase, thioredoxin, redox signaling, phagocytes
- MeSH terms
- Humans, Hydrogen Peroxide, Macrophages, Oxidation-Reduction, Signal Transduction, Respiratory Burst, Protein Tyrosine Phosphatases, Reactive Oxygen Species, Mitogen-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
